Gene Review:
DNAJA1 - DnaJ (Hsp40) homolog, subfamily A, member 1
Homo sapiens
Synonyms:
DJ-2, DNAJ2, DjA1, DnaJ homolog subfamily A member 1, DnaJ protein homolog 2, ...
- Increased expression of HDJ-2 (hsp40) in carotid artery atherosclerosis: a novel heat shock protein associated with luminal stenosis and plaque ulceration. Nguyen, T.Q., Jaramillo, A., Thompson, R.W., Dintzis, S., Oppat, W.F., Allen, B.T., Sicard, G.A., Mohanakumar, T. J. Vasc. Surg. (2001)
- Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease. Wyttenbach, A., Carmichael, J., Swartz, J., Furlong, R.A., Narain, Y., Rankin, J., Rubinsztein, D.C. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1. Cummings, C.J., Mancini, M.A., Antalffy, B., DeFranco, D.B., Orr, H.T., Zoghbi, H.Y. Nat. Genet. (1998)
- DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication. Campbell, K.S., Mullane, K.P., Aksoy, I.A., Stubdal, H., Zalvide, J., Pipas, J.M., Silver, P.A., Roberts, T.M., Schaffhausen, B.S., DeCaprio, J.A. Genes Dev. (1997)
- The human DnaJ homologue dj2 facilitates mitochondrial protein import and luciferase refolding. Terada, K., Kanazawa, M., Bukau, B., Mori, M. J. Cell Biol. (1997)
- Cloning of a unique human homologue of the Escherichia coli DNAJ heat shock protein. Chellaiah, A., Davis, A., Mohanakumar, T. Biochim. Biophys. Acta (1993)
- A role for HDJ-2/HSDJ in correcting subnuclear trafficking, transactivation, and transrepression defects of a glucocorticoid receptor zinc finger mutant. Tang, Y., Ramakrishnan, C., Thomas, J., DeFranco, D.B. Mol. Biol. Cell (1997)
- Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial. Karp, J.E., Lancet, J.E., Kaufmann, S.H., End, D.W., Wright, J.J., Bol, K., Horak, I., Tidwell, M.L., Liesveld, J., Kottke, T.J., Ange, D., Buddharaju, L., Gojo, I., Highsmith, W.E., Belly, R.T., Hohl, R.J., Rybak, M.E., Thibault, A., Rosenblatt, J. Blood (2001)
- Human DnaJ homologs dj2 and dj3, and bag-1 are positive cochaperones of hsc70. Terada, K., Mori, M. J. Biol. Chem. (2000)
- HSDJ, a human homolog of DnaJ, is farnesylated and is involved in protein import into mitochondria. Kanazawa, M., Terada, K., Kato, S., Mori, M. J. Biochem. (1997)
- Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone. Stenoien, D.L., Cummings, C.J., Adams, H.P., Mancini, M.G., Patel, K., DeMartino, G.N., Marcelli, M., Weigel, N.L., Mancini, M.A. Hum. Mol. Genet. (1999)
- Redox-regulated cochaperone activity of the human DnaJ homolog Hdj2. Choi, H.I., Lee, S.P., Kim, K.S., Hwang, C.Y., Lee, Y.R., Chae, S.K., Kim, Y.S., Chae, H.Z., Kwon, K.S. Free Radic. Biol. Med. (2006)
- Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma. Alsina, M., Fonseca, R., Wilson, E.F., Belle, A.N., Gerbino, E., Price-Troska, T., Overton, R.M., Ahmann, G., Bruzek, L.M., Adjei, A.A., Kaufmann, S.H., Wright, J.J., Sullivan, D., Djulbegovic, B., Cantor, A.B., Greipp, P.R., Dalton, W.S., Sebti, S.M. Blood (2004)
- A phase I and pharmacological study of the farnesyl protein transferase inhibitor L-778,123 in patients with solid malignancies. Britten, C.D., Rowinsky, E.K., Soignet, S., Patnaik, A., Yao, S.L., Deutsch, P., Lee, Y., Lobell, R.B., Mazina, K.E., McCreery, H., Pezzuli, S., Spriggs, D. Clin. Cancer Res. (2001)
- Differential inhibition of Hsc70 activities by two Hsc70-binding peptides. Thulasiraman, V., Yun, B.G., Uma, S., Gu, Y., Scroggins, B.T., Matts, R.L. Biochemistry (2002)
- Low resolution structural study of two human HSP40 chaperones in solution. DJA1 from subfamily A and DJB4 from subfamily B have different quaternary structures. Borges, J.C., Fischer, H., Craievich, A.F., Ramos, C.H. J. Biol. Chem. (2005)
- Protein surveillance machinery in brains with spinocerebellar ataxia type 3: redistribution and differential recruitment of 26S proteasome subunits and chaperones to neuronal intranuclear inclusions. Schmidt, T., Lindenberg, K.S., Krebs, A., Schöls, L., Laccone, F., Herms, J., Rechsteiner, M., Riess, O., Landwehrmeyer, G.B. Ann. Neurol. (2002)
- Two populations of neuronal intranuclear inclusions in SCA7 differ in size and promyelocytic leukaemia protein content. Takahashi, J., Fujigasaki, H., Zander, C., El Hachimi, K.H., Stevanin, G., Dürr, A., Lebre, A.S., Yvert, G., Trottier, Y., Thé, H., Hauw, J.J., Duyckaerts, C., Brice, A. Brain (2002)
- Characterization of HDJ-2, a human 40 kD heat shock protein. Davis, A.R., Alevy, Y.G., Chellaiah, A., Quinn, M.T., Mohanakumar, T. Int. J. Biochem. Cell Biol. (1998)
- Increased expression of HDJ-2 (heat shock protein 40) and heat shock protein 70 in biopsy specimens of transplanted human lungs. Rizzo, M., Alevy, Y.G., Sundaresan, S., Lynch, J., Trulock, E.P., Cooper, J.D., Patterson, G.A., Mohanakumar, T. J. Heart Lung Transplant. (1998)
- Comparison of potential markers of farnesyltransferase inhibition. Adjei, A.A., Davis, J.N., Erlichman, C., Svingen, P.A., Kaufmann, S.H. Clin. Cancer Res. (2000)