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Parp  -  Poly-(ADP-ribose) polymerase

Drosophila melanogaster

Synonyms: ADPRT, BEST:LD21673, CG17685, CG17696, CG17718, ...
 
 
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High impact information on Parp

  • The PARP protein of 994 amino acids contains two zinc-finger motifs and an NAD-binding motif, which are conserved among different species [1].
  • We have isolated cDNA clones for a Drosophila poly(ADP-ribose) polymerase (PARP; EC 2.4.2.30) by screening a lambda gt11 cDNA library with a Drosophila partial cDNA fragment [1].
  • Interestingly, the heptad leucine repeat in an alpha-helix was found in Drosophila PARP [1].
  • Organization of exons corresponds to the functional domains of PARP [2].
  • At late stage of embryogenesis PARP mRNA was localized in cells along the central nervous system [2].
 

Biological context of Parp

  • PARP mRNA increased again at 8-12 h and was observed in pupae and adult flies but not in larvae [2].
  • The promoter region of the PARP gene contained putative TATA box and CCAAT box unlike human PARP [2].
  • In this study, we demonstrate that the expression of ExoS in HeLa cells by eukaryotic expression vector effectively caused apoptosis in an ADPRT activity-dependent manner, indicating that ExoS alone is sufficient to trigger apoptotic death of host cells independent of any other bacterial factors [3].
  • The cellular pathway responsible for the ExoS-induced cytotoxicity appears to be well conserved, since the expression of the ADPRT-competent ExoS also induced rapid cell death in the Drosophila melanogaster S2 cell lines [3].

References

  1. Cloning of cDNA encoding Drosophila poly(ADP-ribose) polymerase: leucine zipper in the auto-modification domain. Uchida, K., Hanai, S., Ishikawa, K., Ozawa, Y., Uchida, M., Sugimura, T., Miwa, M. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  2. Genomic organization of Drosophila poly(ADP-ribose) polymerase and distribution of its mRNA during development. Hanai, S., Uchida, M., Kobayashi, S., Miwa, M., Uchida, K. J. Biol. Chem. (1998) [Pubmed]
  3. Expression of Pseudomonas aeruginosa Toxin ExoS Effectively Induces Apoptosis in Host Cells. Jia, J., Wang, Y., Zhou, L., Jin, S. Infect. Immun. (2006) [Pubmed]
 
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