The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

ID3  -  inhibitor of DNA binding 3, dominant...

Homo sapiens

Synonyms: 1R21, BHLHB25, Class B basic helix-loop-helix protein 25, DNA-binding protein inhibitor ID-3, HEIR-1, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of ID3

 

Psychiatry related information on ID3

  • Like its murine counterpart, HLH 1R21 protein functions as an Id (inhibitor of DNA binding) transcription factor by inhibiting the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer oligonucleotide in vitro [6].
 

High impact information on ID3

  • By contrast, ID1 and ID3 did not complex with the OLIG proteins [7].
  • Several genes (IGF-BP3, ID2, and ID3) showed similar responses (increased expression) to DBP and rhBMP-2 [8].
  • The hitherto unrecognized ID (ID3) serves as a fully functional TR binding site, both in vivo and in vitro, and may be the most important for TR binding [9].
  • In addition, HLH 1R21 mRNA transcripts are regulated by phorbol ester treatment of a diverse range of human cell lines and, when overexpressed in mouse NIH3T3 cells, HLH 1R21 induces a morphologically transformed phenotype [6].
  • Conclusions: We report the presence of a VEGF/KDR/ID3-dependent autocrine pathway in FTC133 thyroid cells [10].
 

Chemical compound and disease context of ID3

  • The MicroScan Rapid Neg ID3 panel is designed for the identification of Enterobacteriaceae and nonenteric glucose-fermenting and nonfermenting gram-negative bacilli [11].
 

Biological context of ID3

 

Anatomical context of ID3

  • Mean mRNA levels of ID1 and ID3 were significantly elevated in RA synovia compared with OA by 8.6-fold (P = 0.0044) and 3.3-fold (P = 0.0085), respectively [15].
  • Expression of the ID1 and ID3 genes during chondrocyte differentiation [16].
  • Angle-opening distance at a point 500 m from the scleral spur (AOD500), trabecular-iris angle (theta1), trabecular ciliary process distance (TCPD), ciliary process-iris angle (CPI), iris thickness (ID1, ID3), length of iris-lens contact distance (ILCD) and anterior chamber depth (ACD) were assessed before and after each procedure [17].
 

Associations of ID3 with chemical compounds

  • The products included API 20E, Crystal E/NF, MicroScan Neg ID2 and Rapid Neg ID3, and Vitek GNI+ and ID-GNB [18].
  • Agnathans, chondrichthyes, and teleosts express the three isotypes of IDs: ID1, ID2, and ID3, which are responsible for the peripheral fine-tuning of thyroid hormone (TH) bioactivity [19].
 

Other interactions of ID3

  • To examine BMP target genes, the mRNA expression of ID1, ID3, and MSX2 was determined by quantitative real-time PCR [20].
  • These encode the human transcription factor E2F-2 and the dominant-negative helix-loop-helix gene ID3, respectively [21].
  • Two of the genes [inhibitor of DNA binding-3 (ID3) and thrombospondin-1 (TSP-1)] which showed differential expression in primary thyroid cells were validated in vitro and in vivo [22].
  • Conversely, suppression of PTTG with small interfering RNA was associated with a 2-fold induction of TSP-1 and a 2.2-fold reduction in ID3 expression [22].
  • The MicroScan Rapid Neg ID3 panel (Dade Behring, Inc., West Sacramento, Calif.) is designed for the identification of gram-negative bacilli [3].

References

  1. Expression of ID genes in differentiated elements of human male germ cell tumors. Albanese, J.M., Reuter, V.E., Bosl, G.J., Houldsworth, J., Chaganti, R.S. Diagn. Mol. Pathol. (2001) [Pubmed]
  2. Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development. Ellmeier, W., Aguzzi, A., Kleiner, E., Kurzbauer, R., Weith, A. EMBO J. (1992) [Pubmed]
  3. Evaluation of the MicroScan rapid neg ID3 panel for identification of Enterobacteriaceae and some common gram-negative nonfermenters. O'Hara, C.M., Miller, J.M. J. Clin. Microbiol. (2000) [Pubmed]
  4. Artificial intelligence in pediatrics: important clinical signs in newborn syndromes. Braaten, O. Comput. Biomed. Res. (1996) [Pubmed]
  5. A comparison of logistic regression to decision-tree induction in a medical domain. Long, W.J., Griffith, J.L., Selker, H.P., D'Agostino, R.B. Comput. Biomed. Res. (1993) [Pubmed]
  6. An immediate early human gene encodes an Id-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types. Deed, R.W., Bianchi, S.M., Atherton, G.T., Johnston, D., Santibanez-Koref, M., Murphy, J.J., Norton, J.D. Oncogene (1993) [Pubmed]
  7. Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation. Samanta, J., Kessler, J.A. Development (2004) [Pubmed]
  8. Comparison of TGF-beta/BMP pathways signaled by demineralized bone powder and BMP-2 in human dermal fibroblasts. Zhou, S., Glowacki, J., Yates, K.E. J. Bone Miner. Res. (2004) [Pubmed]
  9. The nuclear receptor corepressor (N-CoR) contains three isoleucine motifs (I/LXXII) that serve as receptor interaction domains (IDs). Webb, P., Anderson, C.M., Valentine, C., Nguyen, P., Marimuthu, A., West, B.L., Baxter, J.D., Kushner, P.J. Mol. Endocrinol. (2000) [Pubmed]
  10. Pituitary Tumor Transforming Gene (PTTG) Stimulates Thyroid Cell Proliferation via a Vascular Endothelial Growth Factor/Kinase Insert Domain Receptor/Inhibitor of DNA Binding-3 Autocrine Pathway. Kim, D.S., Franklyn, J.A., Boelaert, K., Eggo, M.C., Watkinson, J.C., McCabe, C.J. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  11. Ability of the MicroScan rapid gram-negative ID type 3 panel to identify nonenteric glucose-fermenting and nonfermenting gram-negative bacilli. O'Hara, C.M., Miller, J.M. J. Clin. Microbiol. (2002) [Pubmed]
  12. Global expression profiling of fibroblast responses to transforming growth factor-beta1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switching. Chambers, R.C., Leoni, P., Kaminski, N., Laurent, G.J., Heller, R.A. Am. J. Pathol. (2003) [Pubmed]
  13. Expression of the helix-loop-helix protein inhibitor of DNA binding-1 (ID-1) is activated by all-trans retinoic acid in normal human keratinocytes. Villano, C.M., White, L.A. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  14. Phosphorylation of helix-loop-helix proteins ID1, ID2 and ID3. Nagata, Y., Shoji, W., Obinata, M., Todokoro, K. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  15. Expression of ID family genes in the synovia from patients with rheumatoid arthritis. Sakurai, D., Yamaguchi, A., Tsuchiya, N., Yamamoto, K., Tokunaga, K. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  16. Expression of the ID1 and ID3 genes during chondrocyte differentiation. Thornemo, M., Jansson, E.S., Lindahl, A. Ann. N. Y. Acad. Sci. (1996) [Pubmed]
  17. Ultrasound biomicroscopic changes after laser iridotomy or trabeculectomy in angle-closure glaucoma. Yoon, K.C., Won, L.D., Cho, H.J., Yang, K.J. Korean journal of ophthalmology : KJO. (2004) [Pubmed]
  18. Accuracy of six commercially available systems for identification of members of the family vibrionaceae. O'Hara, C.M., Sowers, E.G., Bopp, C.A., Duda, S.B., Strockbine, N.A. J. Clin. Microbiol. (2003) [Pubmed]
  19. Thyroid hormone deiodination in fish. Orozco, A., Valverde-R, C. Thyroid (2005) [Pubmed]
  20. Dysregulation of the BMP-p38 MAPK signaling pathway in cells from patients with fibrodysplasia ossificans progressiva (FOP). Fiori, J.L., Billings, P.C., de la Peña, L.S., Kaplan, F.S., Shore, E.M. J. Bone Miner. Res. (2006) [Pubmed]
  21. Cloning and characterization of CpG islands of the human chromosome 1p36 region. Ellmeier, W., Barnas, C., Kobrna, A., Kleiner, E., Kurzbauer, R., Weith, A. Genomics (1996) [Pubmed]
  22. Pituitary tumor-transforming gene regulates multiple downstream angiogenic genes in thyroid cancer. Kim, D.S., Franklyn, J.A., Stratford, A.L., Boelaert, K., Watkinson, J.C., Eggo, M.C., McCabe, C.J. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
 
WikiGenes - Universities