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Gene Review

IDDM15  -  insulin-dependent diabetes mellitus 15

Homo sapiens

 
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Disease relevance of IDDM15

  • Over the last few years several studies of linkage between non-HLA loci and type 1 diabetes mellitus have mapped several putative susceptibility genes on chromosome 6q; in fact, positive evidence of linkage and/or association of IDDM5 (6q25), IDDM8 (6q27) and IDDM15 (6q21) with type 1 diabetes has been reported [1].
 

High impact information on IDDM15

  • Previous genome screens and studies focused on candidate genes have provided evidence for genetic linkage between polymorphic DNA markers and 15 putative IDDM susceptibility loci, designated IDDM1-IDDM15 [2].
  • In addition to verifying the HLA and INS susceptibility loci, the study provides confirmation of IDDM15 on chromosome 6q21 [3].
  • The method is applied to data from a study of 1056 type 1 diabetes families to examine the evidence for an additional putative locus (IDDM15) on chromosome 6q, linked to IDDM1 in the HLA region on chromosome 6p [4].

References

  1. Analysis of chromosome 6q in Basque families with type 1 diabetes. GEPV-N. Basque-Navarre Endocrinology and Paediatric Group. Pérez De Nanclares, G., Bilbao, J.R., Calvo, B., Castaño, L. Autoimmunity (2000)
  2. A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus. Concannon, P., Gogolin-Ewens, K.J., Hinds, D.A., Wapelhorst, B., Morrison, V.A., Stirling, B., Mitra, M., Farmer, J., Williams, S.R., Cox, N.J., Bell, G.I., Risch, N., Spielman, R.S. Nat. Genet. (1998)
  3. A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: identification of new loci with evidence of interactions. Nerup, J., Pociot, F. Am. J. Hum. Genet. (2001)
  4. A multimarker regression-based test of linkage for affected sib-pairs at two linked loci. Barber, M.J., Todd, J.A., Cordell, H.J. Genet. Epidemiol. (2006)
 
 
 
 
 
 
 
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