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Gene Review

MRP  -  Multidrug-Resistance like Protein 1

Drosophila melanogaster

Synonyms: CG6214, Dmel\CG6214, MRP1, dMRP, dMRP/CG6214, ...
 
 
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Disease relevance of MRP

  • Most of these proteins are known to, or can be inferred to participate in a transport process, such as in the case of the multidrug resistance protein (MDR), the STE6 gene product of yeast, and possibly the cystic fibrosis protein [1].
 

High impact information on MRP

  • The N-terminal portion aligned with the HisP family of membrane-associated ATP-binding proteins, most of which are subunits of active transport complexes in bacteria, and to two regions of the multidrug resistance P-glycoprotein [2].
  • This 19 exon insect gene, dMRP (FBgn0032456), spans slightly more than 22 kb [3].
  • The gene contains two sets of transmembrane domains and two ATP-binding domains and shows a high degree of similarity to the mammalian P-glycoprotein/multidrug resistance (MDR) genes [4].
  • Conservation in the position of intervening sequences between Mdr50 and the human MDR genes provides further evidence for their common origin [4].
  • In situ expression of 2 multidrug resistance genes, mdr49 and mdr65, of Drosophila melanogaster was examined in wild-type third instar larval tissues under physiological conditions and after heat shock or colchicine feeding [5].
 

Biological context of MRP

 

Anatomical context of MRP

  • We now report that MDR in this cell line is partially reversed by the type I cAMP-dependent protein kinase (PKA) inhibitor, 8-Cl-cAMP [7].
 

Analytical, diagnostic and therapeutic context of MRP

  • In situ hybridization and Northern analysis indicate that dMRP is expressed throughout development and appears to be head enriched in adults [8].

References

  1. Bacterial periplasmic permeases belong to a family of transport proteins operating from Escherichia coli to human: Traffic ATPases. Ames, G.F., Mimura, C.S., Shyamala, V. FEMS Microbiol. Rev. (1990) [Pubmed]
  2. The brown protein of Drosophila melanogaster is similar to the white protein and to components of active transport complexes. Dreesen, T.D., Johnson, D.H., Henikoff, S. Mol. Cell. Biol. (1988) [Pubmed]
  3. The Drosophila melanogaster multidrug-resistance protein 1 (MRP1) homolog has a novel gene structure containing two variable internal exons. Grailles, M., Brey, P.T., Roth, C.W. Gene (2003) [Pubmed]
  4. Analysis of Mdr50: a Drosophila P-glycoprotein/multidrug resistance gene homolog. Gerrard, B., Stewart, C., Dean, M. Genomics (1993) [Pubmed]
  5. Expression of mdr49 and mdr65 multidrug resistance genes in larval tissues of Drosophila melanogaster under normal and stress conditions. Tapadia, M.G., Lakhotia, S.C. Cell Stress Chaperones (2005) [Pubmed]
  6. Genetics of alpha-amanitin resistance in a natural population of Drosophila melanogaster. Begun, D.J., Whitley, P. Heredity (2000) [Pubmed]
  7. Regulation of the MDR1 promoter by cyclic AMP-dependent protein kinase and transcription factor Sp1. Rohlff, C., Glazer, R.I. Int. J. Oncol. (1998) [Pubmed]
  8. The dMRP/CG6214 gene of Drosophila is evolutionarily and functionally related to the human multidrug resistance-associated protein family. Tarnay, J.N., Szeri, F., Iliás, A., Annilo, T., Sung, C., Le Saux, O., Váradi, A., Dean, M., Boyd, C.D., Robinow, S. Insect Mol. Biol. (2004) [Pubmed]
 
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