Gene Review:
IGF1 - insulin-like growth factor 1 (somatomedin C)
Homo sapiens
Synonyms:
IBP1, IGF-I, IGF1A, IGFI, Insulin-like growth factor I, ...
Nele Friedrich,
Mattias Johansson,
Georg Brabant,
Henry Völzke,
Robin Haring,
Gang Xi,
Rudolf Kaaks,
Neuhausen,
Henri Wallaschofski,
Henrik Grönberg,
Pär Stattin,
Jan Lüdemann,
Hans-Olov Adami,
Laura A. Maile,
Göran Hallmans,
Ma,
Caan,
Carla H. van Gils,
Matthias Nauck,
Sabina Rinaldi,
Yan Ling,
David R. Clemmons,
Murtaugh,
Slattery,
Katarina Bälter,
Byron E. Capps,
Martijn Verheus,
Sabine Schipf,
James D. McKay,
Samowitz,
Fredrik Wiklund,
Marcus Dörr,
- Binding of mouse VL30 retrotransposon RNA to PSF protein induces genes repressed by PSF: effects on steroidogenesis and oncogenesis. Song, X., Sui, A., Garen, A. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Insulin-like growth factor 1 receptors in human breast cancer and their relation to estradiol and progesterone receptors. Peyrat, J.P., Bonneterre, J., Beuscart, R., Djiane, J., Demaille, A. Cancer Res. (1988)
- Inhibition of apoptosis by amphiregulin via an insulin-like growth factor-1 receptor-dependent pathway in non-small cell lung cancer cell lines. Hurbin, A., Dubrez, L., Coll, J.L., Favrot, M.C. J. Biol. Chem. (2002)
- Lack of insulin-like growth factor 1 (IGF1) in the basal keratinocyte layer of diabetic skin and diabetic foot ulcers. Blakytny, R., Jude, E.B., Martin Gibson, J., Boulton, A.J., Ferguson, M.W. J. Pathol. (2000)
- Implications for prostate cancer of insulin-like growth factor-I (IGF-I) genetic variation and circulating IGF-I levels. Johansson, M., McKay, J.D., Wiklund, F., Rinaldi, S., Verheus, M., van Gils, C.H., Hallmans, G., Bälter, K., Adami, H.O., Grönberg, H., Stattin, P., Kaaks, R. J. Clin. Endocrinol. Metab. (2007)
- Association between serum insulin-like growth factor-I levels and thyroid disorders in a population-based study. Völzke, H., Friedrich, N., Schipf, S., Haring, R., Lüdemann, J., Nauck, M., Dörr, M., Brabant, G., Wallaschofski, H. J. Clin. Endocrinol. Metab. (2007)
- Autocrine stimulation of IGF1 in estrogen-induced growth of endometrial carcinoma cells: involvement of the mitogen-activated protein kinase pathway followed by up-regulation of cyclin D1 and cyclin E. Kashima, H., Shiozawa, T., Miyamoto, T., Suzuki, A., Uchikawa, J., Kurai, M., Konishi, I. Endocr. Relat. Cancer (2009)
- Energy balance, insulin-related genes and risk of colon and rectal cancer. Slattery, M.L., Murtaugh, M., Caan, B., Ma, K.N., Neuhausen, S., Samowitz, W. Int. J. Cancer (2005)
- Expression of mRNA for the insulin-like growth factors and their receptors in human preimplantation embryos. Lighten, A.D., Hardy, K., Winston, R.M., Moore, G.E. Mol. Reprod. Dev. (1997)
- The influence of psychotropic drugs and releasing hormones on anterior pituitary hormone secretion in healthy subjects and depressed patients. Laakmann, G., Hinz, A., Voderholzer, U., Daffner, C., Müller, O.A., Neuhauser, H., Neulinger, E., Wittmann, M. Pharmacopsychiatry (1990)
- Insulin-like growth factor (IGF)-1 and IGF-binding protein-1 concentrations in serum of normal subjects after alcohol ingestion: evidence for decreased IGF-1 bioavailability. Röjdmark, S., Rydvald, Y., Aquilonius, A., Brismar, K. Clin. Endocrinol. (Oxf) (2000)
- Insulin-like growth factors and insulin-like growth factor binding proteins in cerebrospinal fluid and serum of patients with dementia of the Alzheimer type. Tham, A., Nordberg, A., Grissom, F.E., Carlsson-Skwirut, C., Viitanen, M., Sara, V.R. Journal of neural transmission. Parkinson's disease and dementia section. (1993)
- Somatomedin C in rheumatoid arthritis. Isley, W.L., Newton, G., Dev, J., Houk, R.W. N. Engl. J. Med. (1985)
- Children with normal-variant short stature: treatment with human growth hormone for six months. Rudman, D., Kutner, M.H., Blackston, R.D., Cushman, R.A., Bain, R.P., Patterson, J.H. N. Engl. J. Med. (1981)
- Evaluation of acromegaly by radioimmunoassay of somatomedin-C. Clemmons, D.R., Van Wyk, J.J., Ridgway, E.C., Kliman, B., Kjellberg, R.N., Underwood, L.E. N. Engl. J. Med. (1979)
- Letter: Serum somatomedin-C in achondroplasia. Horton, W.A., Rimoin, D.L., Underwood, L.E., Van Wyk, J. N. Engl. J. Med. (1976)
- Breast cancer: further metabolic-endocrine risk markers? Stoll, B.A. Br. J. Cancer (1997)
- Decreased dehydroepiandrosterone sulfate but normal insulin-like growth factor in chronic fatigue syndrome (CFS): relevance for the inflammatory response in CFS. Maes, M., Mihaylova, I., De Ruyter, M. Neuro Endocrinol. Lett. (2005)
- Substrate specificities of the insulin and insulin-like growth factor 1 receptor tyrosine kinase catalytic domains. Xu, B., Bird, V.G., Miller, W.T. J. Biol. Chem. (1995)
- Steroid-sensitive proteins, growth hormone and somatomedin C in prostatic cancer: effects of parenteral and oral estrogen therapy. Stege, R., Fröhlander, N., Carlström, K., Pousette, A., von Schoultz, B. Prostate (1987)
- Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus. Almind, K., Bjørbaek, C., Vestergaard, H., Hansen, T., Echwald, S., Pedersen, O. Lancet (1993)
- Growth-promoting effects of insulin-like growth factor-1 (IGF-1) on hematopoietic cells: overexpression of introduced IGF-1 receptor abrogates interleukin-3 dependency of murine factor-dependent cells by a ligand-dependent mechanism. McCubrey, J.A., Steelman, L.S., Mayo, M.W., Algate, P.A., Dellow, R.A., Kaleko, M. Blood (1991)
- Estrogen augments glucose transporter and IGF1 expression in primate cerebral cortex. Cheng, C.M., Cohen, M., Wang, J., Bondy, C.A. FASEB J. (2001)
- Insulin-like growth factor 2 and overgrowth: molecular biology and clinical implications. Morison, I.M., Reeve, A.E. Molecular medicine today. (1998)
- Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture. Meyer-Franke, A., Kaplan, M.R., Pfrieger, F.W., Barres, B.A. Neuron (1995)
- Role of muscle insulin-like growth factors in nerve sprouting: suppression of terminal sprouting in paralyzed muscle by IGF-binding protein 4. Caroni, P., Schneider, C., Kiefer, M.C., Zapf, J. J. Cell Biol. (1994)
- Role of extracellular electrolytes in the activation of ribosomal protein S6 kinase by epidermal growth factor, insulin-like growth factor 1, and insulin in ZR-75-1 cells. Novak-Hofer, I., Küng, W., Eppenberger, U. J. Cell Biol. (1988)
- Expression and characterization of an antibody binding specificity joined to insulin-like growth factor 1: potential applications for cellular targeting. Shin, S.U., Morrison, S.L. Proc. Natl. Acad. Sci. U.S.A. (1990)
- Regulation of lipoprotein lipase in primary cultures of isolated human adipocytes. Kern, P.A., Marshall, S., Eckel, R.H. J. Clin. Invest. (1985)
- Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells. Hurbin, A., Coll, J.L., Dubrez-Daloz, L., Mari, B., Auberger, P., Brambilla, C., Favrot, M.C. J. Biol. Chem. (2005)
- Functional properties of antibody insulin-like growth factor fusion proteins. Shin, S.U., Friden, P., Moran, M., Morrison, S.L. J. Biol. Chem. (1994)
- Hyperglycemia alters the responsiveness of smooth muscle cells to insulin-like growth factor-I. Maile, L.A., Capps, B.E., Ling, Y., Xi, G., Clemmons, D.R. Endocrinology (2007)
- The insulin-like growth factor-I response to growth hormone is increased in prepubertal children with obesity and tall stature. Bouhours-Nouet, N., Gatelais, F., Boux de Casson, F., Rouleau, S., Coutant, R. J. Clin. Endocrinol. Metab. (2007)
- Association analysis of the IGF1 gene with childhood growth, IGF-1 concentrations and type 1 diabetes. Vella, A., Bouatia-Naji, N., Heude, B., Cooper, J.D., Lowe, C.E., Petry, C., Ring, S.M., Dunger, D.B., Todd, J.A., Ong, K.K. Diabetologia (2008)
- Ontogenesis of somatomedin and insulin receptors in the human fetus. Sara, V.R., Hall, K., Misaki, M., Fryklund, L., Christensen, N., Wetterberg, L. J. Clin. Invest. (1983)
- Positively charged side chains in the insulin-like growth factor-1 C- and D-regions determine receptor binding specificity. Zhang, W., Gustafson, T.A., Rutter, W.J., Johnson, J.D. J. Biol. Chem. (1994)
- A keratinocyte cell line synthesizes a predominant insulin-like growth factor-binding protein (IGFBP-3) that modulates insulin-like growth factor-I action. Wraight, C.J., Murashita, M.M., Russo, V.C., Werther, G.A. J. Invest. Dermatol. (1994)
- Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin-like growth factor-1. Vardy, D.A., Kari, C., Lazarus, G.S., Jensen, P.J., Zilberstein, A., Plowman, G.D., Rodeck, U. J. Cell. Physiol. (1995)
- Chromatographic characterization of insulin-like growth factor-binding proteins in human pregnancy serum. Wang, H.S., Chard, T. J. Endocrinol. (1992)
- Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. Fukuda, R., Hirota, K., Fan, F., Jung, Y.D., Ellis, L.M., Semenza, G.L. J. Biol. Chem. (2002)
- Transactivation of the EGF receptor mediates IGF-1-stimulated shc phosphorylation and ERK1/2 activation in COS-7 cells. Roudabush, F.L., Pierce, K.L., Maudsley, S., Khan, K.D., Luttrell, L.M. J. Biol. Chem. (2000)
- Insulin-like growth factor-1 regulates endogenous RUNX2 activity in endothelial cells through a phosphatidylinositol 3-kinase/ERK-dependent and Akt-independent signaling pathway. Qiao, M., Shapiro, P., Kumar, R., Passaniti, A. J. Biol. Chem. (2004)
- Endogenous prostaglandin E2 and insulin-like growth factor 1 can modulate the levels of parathyroid hormone receptor in human osteoarthritic osteoblasts. Hilal, G., Massicotte, F., Martel-Pelletier, J., Fernandes, J.C., Pelletier, J.P., Lajeunesse, D. J. Bone Miner. Res. (2001)
- Interaction of scaffolding adaptor protein Gab1 with tyrosine phosphatase SHP2 negatively regulates IGF-I-dependent myogenic differentiation via the ERK1/2 signaling pathway. Koyama, T., Nakaoka, Y., Fujio, Y., Hirota, H., Nishida, K., Sugiyama, S., Okamoto, K., Yamauchi-Takihara, K., Yoshimura, M., Mochizuki, S., Hori, M., Hirano, T., Mochizuki, N. J. Biol. Chem. (2008)
- Interaction between the insulin-like growth factor family and the integrin receptor family in tissue repair processes. Evidence in a rabbit ear dermal ulcer model. Galiano, R.D., Zhao, L.L., Clemmons, D.R., Roth, S.I., Lin, X., Mustoe, T.A. J. Clin. Invest. (1996)
- Receptor-specific induction of insulin-like growth factor I in human monocytes by advanced glycosylation end product-modified proteins. Kirstein, M., Aston, C., Hintz, R., Vlassara, H. J. Clin. Invest. (1992)
- Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin. Wu, X., Fan, Z., Masui, H., Rosen, N., Mendelsohn, J. J. Clin. Invest. (1995)
- Insulinlike growth factor-binding protein modulates the growth response to insulinlike growth factor 1 by human gastric cancer cells. Guo, Y.S., Beauchamp, R.D., Jin, G.F., Townsend, C.M., Thompson, J.C. Gastroenterology (1993)
- Intratumoral IGF-I protein expression is selectively upregulated in breast cancer patients with BRCA1/2 mutations. Hudelist, G., Wagner, T., Rosner, M., Fink-Retter, A., Gschwantler-Kaulich, D., Czerwenka, K., Kroiss, R., Tea, M., Pischinger, K., Köstler, W.J., Attems, J., Mueller, R., Blaukopf, C., Kubista, E., Hengstschläger, M., Singer, C.F. Endocr. Relat. Cancer (2007)
- The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway. McMullen, J.R., Shioi, T., Huang, W.Y., Zhang, L., Tarnavski, O., Bisping, E., Schinke, M., Kong, S., Sherwood, M.C., Brown, J., Riggi, L., Kang, P.M., Izumo, S. J. Biol. Chem. (2004)
- Clinical pharmacokinetics of octreotide. Therapeutic applications in patients with pituitary tumours. Chanson, P., Timsit, J., Harris, A.G. Clinical pharmacokinetics. (1993)
- Impact of constitutive IGF1/IGF2 stimulation on the transcriptional program of human breast cancer cells. Pacher, M., Seewald, M.J., Mikula, M., Oehler, S., Mogg, M., Vinatzer, U., Eger, A., Schweifer, N., Varecka, R., Sommergruber, W., Mikulits, W., Schreiber, M. Carcinogenesis (2007)
- Polymorphism and mapping of the IGF1 gene, and absence of association with stature among African Pygmies. Bowcock, A., Sartorelli, V. Hum. Genet. (1990)