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MAST1  -  microtubule associated serine/threonine...

Rattus norvegicus

 
 
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Disease relevance of MAST1

  • BACKGROUND: Mast cells are growth factor-rich, bone marrow-derived cells that infiltrate injured tissue where they have been implicated in the pathogenesis of progressive fibrosis [1].
  • PURPOSE: Mast cell activation and stress have been suggested as factors in the pathogenesis of interstitial cystitis, a painful disorder of the bladder that is diagnosed more frequently in women and characterized by increased urgency and frequency with absent infection [2].
  • Mast Cell Stabilizer Ketotifen [4-(1-Methyl-4-piperidylidene)-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one Fumarate] Prevents Mucosal Mast Cell Hyperplasia and Intestinal Dysmotility in Experimental Trichinella spiralis Inflammation in the Rat [3].
  • BACKGROUND: Mast cell-derived vasoactive and pro-inflammatory mediators, particularly histamine, might contribute to local tissue damage and multiorgan dysfunction induced by intestinal ischemia/reperfusion (I/R) [4].
  • OBJECTIVE: Mast cell tryptase has been proposed to be involved in the pathogenesis of human inflammatory bowel disease (IBD) [5].
 

Psychiatry related information on MAST1

  • METHODS: Mast cell-deficient (Ws/Ws) rats and wild-type control (+/+) rats were submitted to water avoidance stress or sham stress (1 h/day) for 10 consecutive days, as a model of ongoing life stress [6].
 

High impact information on MAST1

  • Identification of targeting proteinase for rat alpha 1-macroglobulin in vivo. Mast-cell tryptase is a major component of the alpha 1-macroglobulin-proteinase complex endocytosed into rat liver lysosomes [7].
  • The putative substrate binding site resembles that of carboxypeptidase A, although other structural features bear more similarity to carboxypeptidase B. Mast cell carboxypeptidase retains enzymatic activity toward a peptide substrate (angiotensin I) while bound within the granular matrix of the rat connective tissue mast cells [8].
  • 2. Mast cell degranulation caused by compound 48/80 (10 mg kg-1) or by allergen challenge in rats sensitized to Nippostrongylus brasiliensis also suppressed rat hind paw oedema in the same test [9].
  • Three analogs of Mast Cell Degranulating (MCD) peptide with C-terminal and one analog with N- and C-terminal deletions were synthesized and assayed for histamine-releasing activity in mast cells [10].
  • 4. Mast cell activation by bradykinin and DSA was not inhibited by anionic polymers, suggesting that both bradykinin and DSA recognize membrane sites as receptors [11].
 

Anatomical context of MAST1

  • 2. Mast cell numbers vary considerably from one individual to another and from one location in the choroid to another [12].
  • Inflammatory cells and the epithelium. Mast cell/nerve interactions in the lung in vitro and in vivo [13].
  • The non-specific and reversible smooth muscle relaxant activities of the ethanolic extract (EE) of Aristolochia papillaris Mast., a fraction of EE containing tertiary alkaloids (TAF) and of 3 compounds isolated from TAF are reported [14].
 

Associations of MAST1 with chemical compounds

  • 4. Mast cell activation induced by PEI6 was sugar-specifically inhibited by N-acetylglucosamine(Glc-NAc)-specific lectins and/or by sialic acid (Sia)-specific lectins, suggesting that the action sites for PEI6 were glycoproteins having GlcNAc and/or Sia residues [15].
 

Analytical, diagnostic and therapeutic context of MAST1

  • METHODS: Mast cell infiltration and the expression of related chemoattractants was examined following 5/6 nephrectomy, a model of progressive, nonimmune-mediated renal injury [1].
  • BACKGROUND AND OBJECTIVE: Mast cell activation by low-level laser therapy (LLLT), leading to degranulation and the release of mediators, may be one of the mechanisms by which LLLT can accelerate tissue repair in mammals [16].

References

  1. Mast cell infiltration and chemokine expression in progressive renal disease. Jones, S.E., Kelly, D.J., Cox, A.J., Zhang, Y., Gow, R.M., Gilbert, R.E. Kidney Int. (2003) [Pubmed]
  2. Intravesical sodium hyaluronate inhibits the rat urinary mast cell mediator increase triggered by acute immobilization stress. Boucher, W.S., Letourneau, R., Huang, M., Kempuraj, D., Green, M., Sant, G.R., Theoharides, T.C. J. Urol. (2002) [Pubmed]
  3. Mast Cell Stabilizer Ketotifen [4-(1-Methyl-4-piperidylidene)-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one Fumarate] Prevents Mucosal Mast Cell Hyperplasia and Intestinal Dysmotility in Experimental Trichinella spiralis Inflammation in the Rat. Serna, H., Porras, M., Vergara, P. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  4. Ketotifen abrogates local and systemic consequences of rat intestinal ischemia-reperfusion injury. Kalia, N., Brown, N.J., Wood, R.F., Pockley, A.G. J. Gastroenterol. Hepatol. (2005) [Pubmed]
  5. Anti-tryptase treatment using nafamostat mesilate has a therapeutic effect on experimental colitis. Isozaki, Y., Yoshida, N., Kuroda, M., Handa, O., Takagi, T., Kokura, S., Ichikawa, H., Naito, Y., Okanoue, T., Yoshikawa, T. Scand. J. Gastroenterol. (2006) [Pubmed]
  6. Chronic stress induces mast cell-dependent bacterial adherence and initiates mucosal inflammation in rat intestine. Söderholm, J.D., Yang, P.C., Ceponis, P., Vohra, A., Riddell, R., Sherman, P.M., Perdue, M.H. Gastroenterology (2002) [Pubmed]
  7. Identification of targeting proteinase for rat alpha 1-macroglobulin in vivo. Mast-cell tryptase is a major component of the alpha 1-macroglobulin-proteinase complex endocytosed into rat liver lysosomes. Tsuji, A., Akamatsu, T., Nagamune, H., Matsuda, Y. Biochem. J. (1994) [Pubmed]
  8. Rat mast cell carboxypeptidase: amino acid sequence and evidence of enzyme activity within mast cell granules. Cole, K.R., Kumar, S., Trong, H.L., Woodbury, R.G., Walsh, K.A., Neurath, H. Biochemistry (1991) [Pubmed]
  9. Anti-inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) and compound 48/80 results from mast cell degranulation in vivo. Banks, B.E., Dempsey, C.E., Vernon, C.A., Warner, J.A., Yamey, J. Br. J. Pharmacol. (1990) [Pubmed]
  10. Bioactivities and secondary structure of mast cell degranulating (MCD) peptide analogs. Buku, A., Maulik, G., Hook, W.A. Peptides (1998) [Pubmed]
  11. Benzalkonium chloride inhibited the histamine release from rat peritoneal mast cells induced by bradykinin and GlcNAc oligomer-specific lectin Datura stramonium agglutinin, but heparin did not. Niitsuma, A., Uchida, M.K., Suzuki-Nishimura, T. Gen. Pharmacol. (1996) [Pubmed]
  12. Characterization of the choroidal mast cell. Godfrey, W.A. Transactions of the American Ophthalmological Society. (1987) [Pubmed]
  13. Inflammatory cells and the epithelium. Mast cell/nerve interactions in the lung in vitro and in vivo. Bienenstock, J., Perdue, M., Blennerhassett, M., Stead, R., Kakuta, N., Sestini, P., Vancheri, C., Marshall, J. Am. Rev. Respir. Dis. (1988) [Pubmed]
  14. Pharmacological studies on Aristolochia papillaris Mast. (Aristolochiaceae). Lemos, V.S., Thomas, G., Barbosa Filho, J.M. Journal of ethnopharmacology. (1993) [Pubmed]
  15. PEI6, a new basic secretagogue in rat peritoneal mast cells: characteristics of polyethylenimine PEI6 resemble those of compound 48/80. Suzuki-Nishimura, T., Oku, N., Nango, M., Uchida, M.K. Gen. Pharmacol. (1995) [Pubmed]
  16. Effect of laser pulse repetition rate and pulse duration on mast cell number and degranulation. el Sayed, S.O., Dyson, M. Lasers in surgery and medicine. (1996) [Pubmed]
 
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