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Gene: szl  -  sizzled

Danio rerio

Synonyms: sfrp, slz
 
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High impact information on szl

  • The ventral ogon/sizzled expression in the gastrula stage was reduced or absent in the swirl/bmp2b mutants but expanded in the chordino mutants [1].
  • Misexpression of ogon/sizzled did not dorsalize the chordino mutants, suggesting that Ogon/Sizzled required Chordin protein for dorsalization and Bmp inhibition [1].
  • Ogon/Sizzled did not inhibit a Wnt8-dependent transcription in the zebrafish embryo. ogon/sizzled was expressed on the ventral side from the late blastula through the gastrula stages [1].
  • Overexpression of sizzled, resulting in strongly dorsalized phenotypes, and the expression domains of sizzled in wild type embryos, localized in the ventral side during gastrulation and restricted to the posterior end during segmentation stages, correlate with its role in dorsoventral patterning [2].
  • The expanded expression domain of sizzled in ogon and chordino together with its downregulation in swirl suggests a BMP2b-dependent negative autoregulation of sizzled [2].
 

Anatomical context of szl

  • Surprisingly, 24% of previously identified bona fide secretory proteins corresponded to four secreted Wnt antagonists of the same family: frzb-1, sizzled, sfrp-2 and crescent. sfrp-2 and crescent are novel components of the growing cocktail of growth factor antagonists secreted by Spemann organizer cells in Xenopus [3].

References

  1. Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling. Yabe, T., Shimizu, T., Muraoka, O., Bae, Y.K., Hirata, T., Nojima, H., Kawakami, A., Hirano, T., Hibi, M. Development (2003)
  2. The ventralized ogon mutant phenotype is caused by a mutation in the zebrafish homologue of Sizzled, a secreted Frizzled-related protein. Martyn, U., Schulte-Merker, S. Dev. Biol. (2003)
  3. A direct screen for secreted proteins in Xenopus embryos identifies distinct activities for the Wnt antagonists Crescent and Frzb-1. Pera, E.M., De Robertis, E.M. Mech. Dev. (2000)
 
 
 
 
 
 
 
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