Gene Review:
ced-9 - Protein CED-9
Caenorhabditis elegans
- Baculovirus p35 prevents developmentally programmed cell death and rescues a ced-9 mutant in the nematode Caenorhabditis elegans. Sugimoto, A., Friesen, P.D., Rothman, J.H. EMBO J. (1994)
- The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9. Conradt, B., Horvitz, H.R. Cell (1998)
- An alternatively spliced C. elegans ced-4 RNA encodes a novel cell death inhibitor. Shaham, S., Horvitz, H.R. Cell (1996)
- C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Hengartner, M.O., Horvitz, H.R. Cell (1994)
- Activation of C. elegans cell death protein CED-9 by an amino-acid substitution in a domain conserved in Bcl-2. Hengartner, M.O., Horvitz, H.R. Nature (1994)
- Mechanisms of apoptosis: integration of genetic, biochemical, and cellular indicators. Stewart, B.W. J. Natl. Cancer Inst. (1994)
- CED-4 induces chromatin condensation in Schizosaccharomyces pombe and is inhibited by direct physical association with CED-9. James, C., Gschmeissner, S., Fraser, A., Evan, G.I. Curr. Biol. (1997)
- Demonstration of the in vivo interaction of key cell death regulators by structure-based design of second-site suppressors. Parrish, J., Metters, H., Chen, L., Xue, D. Proc. Natl. Acad. Sci. U.S.A. (2000)
- DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans. Jagasia, R., Grote, P., Westermann, B., Conradt, B. Nature (2005)
- Interaction and regulation of subcellular localization of CED-4 by CED-9. Wu, D., Wallen, H.D., Nuñez, G. Science (1997)
- Bcl-2 overexpression blocks activation of the death protease CPP32/Yama/apopain. Monney, L., Otter, I., Olivier, R., Ravn, U., Mirzasaleh, H., Fellay, I., Poirier, G.G., Borner, C. Biochem. Biophys. Res. Commun. (1996)
- Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans. Yan, N., Chai, J., Lee, E.S., Gu, L., Liu, Q., He, J., Wu, J.W., Kokel, D., Li, H., Hao, Q., Xue, D., Shi, Y. Nature (2005)
- Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death. Chen, F., Hersh, B.M., Conradt, B., Zhou, Z., Riemer, D., Gruenbaum, Y., Horvitz, H.R. Science (2000)