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Pkn  -  Protein kinase related to protein kinase N

Drosophila melanogaster

Synonyms: 3-2, CG2049, CG2055, CT6637, CT6660, ...
 
 
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High impact information on Pkn

  • The PKN family of PKC-related protein kinases constitutes the major Rho GTPase-associated protein kinase activities detected in mammalian tissues [1].
  • The Drosophila Pkn protein kinase is a Rho/Rac effector target required for dorsal closure during embryogenesis [1].
  • Characterization of a loss-of-function mutant of Drosophila Pkn revealed that this kinase is required specifically for the epidermal cell shape changes during the morphogenetic process of dorsal closure of the developing embryo [1].
  • We identified a novel Drosophila gene, Dpkn (Drosophila protein kinase related to PKN), encoding a putative protein serine/threonine kinase [2].
  • By using RT-PCR and 3' RACE we have identified two major PKN transcripts that are produced by alternative polyadenylation [3].

References

  1. The Drosophila Pkn protein kinase is a Rho/Rac effector target required for dorsal closure during embryogenesis. Lu, Y., Settleman, J. Genes Dev. (1999) [Pubmed]
  2. Identification of a novel Drosophila protein kinase highly homologous to protein kinase N (PKN). Ueno, N., Oishi, I., Sugiyama, S., Nishida, Y., Minami, Y., Yamamura, H. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  3. The mouse genes for the EP1 prostanoid receptor and the PKN protein kinase overlap. Båtshake, B., Sundelin, J. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
 
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