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Gene Review: 

fgf24  -  fibroblast growth factor 24

Danio rerio

 
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High impact information on fgf24

 

Anatomical context of fgf24

  • We found that inhibiting fgf24 function alone has no affect on the formation of posterior mesoderm [1].

 

Evolutionary origin

Phylogenetic analysis of fgf24 suggests it belongs to the Fgf8/17/18 family of genes that diversified through duplication in the vertebrate lineage. fgf24 has only been identified so far in teleost fish. However, comparative genomics suggests that, rather being a fish specific duplication, fgf24 is an ohnolog (one of the paralogs produced via whole genome duplication) lost from other vertebrate genomes [3]

References

  1. Zebrafish fgf24 functions with fgf8 to promote posterior mesodermal development. Draper, B.W., Stock, D.W., Kimmel, C.B. Development (2003)
  2. The zebrafish fgf24 mutant identifies an additional level of Fgf signaling involved in vertebrate forelimb initiation. Fischer, S., Draper, B.W., Neumann, C.J. Development (2003)
  3. Comparative genomics of Lbx loci reveals conservation of identical Lbx ohnologs in bony vertebrates. Wotton, K.R., Weierud, F.K., Dietrich, S., Lewis, K.E. BMC. Evol. Biol. (2008)
 
 
 
 
 
 
 
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