Gene Review:
IL18 - interleukin 18
Homo sapiens
Synonyms:
IFN-gamma-inducing factor, IGIF, IL-1 gamma, IL-18, IL-1g, ...
Young,
Dinarello,
Papadakis,
Eigenbrot,
Tracey,
Mahaira,
Henzel,
Risser,
Perez,
Chang,
Riedel,
Jenneck,
Avanesyan,
Mohammad A. Amin,
Baldwin,
Pamela J. Mansfield,
Kane,
Ghayur,
Mintz,
McCann,
Köller,
Lubberts,
Pelloso,
Yansura,
Murphy,
Selzman,
Fantuzzi,
Prehn,
Salagianni,
Herzog,
Talanian,
Brown,
Rita J. Martinez,
van den Berg,
Lewis,
Vandlen,
Fimmers,
Papamichail,
Kim,
Sotiriadou,
Olsen,
Bieber,
Haas,
Filvaroff,
Jander,
Paskind,
Quintal,
Zhu,
Vanderah,
Pan,
Carter,
Goll,
Reighard,
Banerjee,
Salahuddin Ahmed,
Butler,
Kamen,
Joosten,
Kohut,
Hugunin,
Feick,
Phillip L. Campbell,
Lafkas,
Kaplan,
Angela Pakozdi,
Stuyt,
Russell,
Zhong,
Baxevanis,
Landers,
Cunnick,
Novak,
Hamilton,
Jedlicka,
Bresnihan,
Reznikov,
Castillo,
Maintz,
Sekut,
Kruse,
Franke,
FitzGerald,
Scott,
Barrera,
Florholmen,
Robertson,
Cui,
Gritzapis,
Hoshino,
Arendt,
Allen,
van Lent,
Dayer,
Götte,
von Giesen,
Konopka,
Hörmann,
Weidinger,
Alisa E. Koch,
van den Bersselaar,
Potreck,
Targan,
van Riel,
Adam,
Roux-Lombard,
Kleeberger,
Mao,
Radstake,
Wong,
- Single nucleotide polymorphisms of the IL18 gene are associated with atopic eczema. Novak, N., Kruse, S., Potreck, J., Maintz, L., Jenneck, C., Weidinger, S., Fimmers, R., Bieber, T. J. Allergy Clin. Immunol. (2005)
- IL18 polymorphism is associated with an increased risk of Crohn's disease. Tamura, K., Fukuda, Y., Sashio, H., Takeda, N., Bamba, H., Kosaka, T., Fukui, S., Sawada, K., Tamura, K., Satomi, M., Yamada, T., Yamamura, T., Yamamoto, Y., Furuyama, J., Okamura, H., Shimoyama, T. J. Gastroenterol. (2002)
- Human pancreatic carcinoma cells secrete bioactive interleukin-18 after treatment with 5-fluorouracil: implications for anti-tumor immune response. Carbone, A., Rodeck, U., Mauri, F.A., Sozzi, M., Gaspari, F., Smirne, C., Prati, A., Addeo, A., Novarino, A., Robecchi, A., Bertetto, O., Emanuelli, G., Bellone, G. Cancer Biol. Ther. (2005)
- Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis. Gerdes, N., Sukhova, G.K., Libby, P., Reynolds, R.S., Young, J.L., Schönbeck, U. J. Exp. Med. (2002)
- Elevated levels of interleukin-18 predict the development of type 2 diabetes: results from the MONICA/KORA Augsburg Study, 1984-2002. Thorand, B., Kolb, H., Baumert, J., Koenig, W., Chambless, L., Meisinger, C., Illig, T., Martin, S., Herder, C. Diabetes (2005)
- Soluble interleukin-1 receptor type II, IL-18 and caspase-1 in mild cognitive impairment and severe Alzheimer's disease. Lindberg, C., Chromek, M., Ahrengart, L., Brauner, A., Schultzberg, M., Garlind, A. Neurochem. Int. (2005)
- IL-18 in patients with multiple sclerosis. Losy, J., Niezgoda, A. Acta neurologica Scandinavica. (2001)
- Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of beta-blockers, BMI, and psychosocial factors in older adults. Kohut, M.L., McCann, D.A., Russell, D.W., Konopka, D.N., Cunnick, J.E., Franke, W.D., Castillo, M.C., Reighard, A.E., Vanderah, E. Brain Behav. Immun. (2006)
- Serum and cerebrospinal fluid levels of interleukin-18 in human immunodeficiency virus type 1-associated central nervous system disease. von Giesen, H.J., Jander, S., Köller, H., Arendt, G. J. Neurovirol. (2004)
- X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling. Döffinger, R., Smahi, A., Bessia, C., Geissmann, F., Feinberg, J., Durandy, A., Bodemer, C., Kenwrick, S., Dupuis-Girod, S., Blanche, S., Wood, P., Rabia, S.H., Headon, D.J., Overbeek, P.A., Le Deist, F., Holland, S.M., Belani, K., Kumararatne, D.S., Fischer, A., Shapiro, R., Conley, M.E., Reimund, E., Kalhoff, H., Abinun, M., Munnich, A., Israël, A., Courtois, G., Casanova, J.L. Nat. Genet. (2001)
- Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production. Ghayur, T., Banerjee, S., Hugunin, M., Butler, D., Herzog, L., Carter, A., Quintal, L., Sekut, L., Talanian, R., Paskind, M., Wong, W., Kamen, R., Tracey, D., Allen, H. Nature (1997)
- Cloning of a new cytokine that induces IFN-gamma production by T cells. Okamura, H., Tsutsi, H., Komatsu, T., Yutsudo, M., Hakura, A., Tanimoto, T., Torigoe, K., Okura, T., Nukada, Y., Hattori, K. Nature (1995)
- Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme. Gu, Y., Kuida, K., Tsutsui, H., Ku, G., Hsiao, K., Fleming, M.A., Hayashi, N., Higashino, K., Okamura, H., Nakanishi, K., Kurimoto, M., Tanimoto, T., Flavell, R.A., Sato, V., Harding, M.W., Livingston, D.J., Su, M.S. Science (1997)
- Interleukin 18 stimulates HIV type 1 in monocytic cells. Shapiro, L., Puren, A.J., Barton, H.A., Novick, D., Peskind, R.L., Shenkar, R., Gu, Y., Su, M.S., Dinarello, C.A. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Molecular characterization of the acute inflammatory response to infections with gram-negative versus gram-positive bacteria. Feezor, R.J., Oberholzer, C., Baker, H.V., Novick, D., Rubinstein, M., Moldawer, L.L., Pribble, J., Souza, S., Dinarello, C.A., Ertel, W., Oberholzer, A. Infect. Immun. (2003)
- Thalidomide reduces IL-18, IL-8 and TNF-{alpha} release from alveolar macrophages in interstitial lung disease. Ye, Q., Chen, B., Tong, Z., Nakamura, S., Sarria, R., Costabel, U., Guzman, J. Eur. Respir. J. (2006)
- Expression of IL-18 in patients with head and neck squamous cell carcinoma. Riedel, F., Adam, S., Feick, P., Haas, S., Götte, K., Hörmann, K. Int. J. Mol. Med. (2004)
- Regulation of human IL-18 mRNA expression. Marshall, J.D., Aste-Amézaga, M., Chehimi, S.S., Murphy, M., Olsen, H., Trinchieri, G. Clin. Immunol. (1999)
- Mantle cell lymphomas express a distinct genetic signature affecting lymphocyte trafficking and growth regulation as compared with subpopulations of normal human B cells. Ek, S., Högerkorp, C.M., Dictor, M., Ehinger, M., Borrebaeck, C.A. Cancer Res. (2002)
- Analysis of polymorphisms of the interleukin-18 gene in type 1 diabetes and Hardy-Weinberg equilibrium testing. Szeszko, J.S., Howson, J.M., Cooper, J.D., Walker, N.M., Twells, R.C., Stevens, H.E., Nutland, S.L., Todd, J.A. Diabetes (2006)
- Polymorphisms in the IL 18 gene are associated with specific sensitization to common allergens and allergic rhinitis. Kruse, S., Kuehr, J., Moseler, M., Kopp, M.V., Kurz, T., Deichmann, K.A., Foster, P.S., Mattes, J. J. Allergy Clin. Immunol. (2003)
- Dominant role for TL1A/DR3 pathway in IL-12 plus IL-18-induced IFN-gamma production by peripheral blood and mucosal CCR9+ T lymphocytes. Papadakis, K.A., Zhu, D., Prehn, J.L., Landers, C., Avanesyan, A., Lafkas, G., Targan, S.R. J. Immunol. (2005)
- cis-Element clustering correlates with dose-dependent pro- and antisignaling effects of IL18. Leyfer, D., Bond, A., Tworog, E., Perron, D., Maska, S., Brito, A., Kamens, J., Weng, Z., Voss, J. Genes Immun. (2004)
- Raised plasma concentration and ex vivo production of inflammatory chemokines in patients with systemic lupus erythematosus. Lit, L.C., Wong, C.K., Tam, L.S., Li, E.K., Lam, C.W. Ann. Rheum. Dis. (2006)
- Implication of interleukin 18 in production of matrix metalloproteinases in articular chondrocytes in arthritis: direct effect on chondrocytes may not be pivotal. Dai, S.M., Shan, Z.Z., Nishioka, K., Yudoh, K. Ann. Rheum. Dis. (2005)
- Novel targets for interleukin 18 binding protein. Dinarello, C.A. Ann. Rheum. Dis. (2001)
- Genetic predisposition to latex allergy: role of interleukin 13 and interleukin 18. Brown, R.H., Hamilton, R.G., Mintz, M., Jedlicka, A.E., Scott, A.L., Kleeberger, S.R. Anesthesiology (2005)
- Serum interleukin 18 and interleukin 18 binding protein in rheumatoid arthritis. Bresnihan, B., Roux-Lombard, P., Murphy, E., Kane, D., FitzGerald, O., Dayer, J.M. Ann. Rheum. Dis. (2002)
- Interleukin-18 enhances lipopolysaccharide-induced interferon-gamma production in human whole blood cultures. Puren, A.J., Razeghi, P., Fantuzzi, G., Dinarello, C.A. J. Infect. Dis. (1998)
- Impaired release of IL-18 from fibroblast-like synoviocytes activated with protein I/II, a pathogen-associated molecular pattern from oral streptococci, results from defective translation of IL-18 mRNA in pro-IL-18. Zeisel, M.B., Neff, L.A., Randle, J., Klein, J.P., Sibilia, J., Wachsmann, D. Cell. Microbiol. (2004)
- Evidence for a pathogenetic role of interleukin-18 in cutaneous lupus erythematosus. Wang, D., Drenker, M., Eiz-Vesper, B., Werfel, T., Wittmann, M. Arthritis Rheum. (2008)
- IL-12 induces monocyte IL-18 binding protein expression via IFN-gamma. Veenstra, K.G., Jonak, Z.L., Trulli, S., Gollob, J.A. J. Immunol. (2002)
- IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp. Pan, G., Risser, P., Mao, W., Baldwin, D.T., Zhong, A.W., Filvaroff, E., Yansura, D., Lewis, L., Eigenbrot, C., Henzel, W.J., Vandlen, R. Cytokine (2001)
- Rational design of an EGF-IL18 fusion protein: implication for developing tumor therapeutics. Lu, J.X., Peng, Y., Meng, Z.F., Jin, L.Q., Lu, Y.S., Guan, M.X. Biochem. Biophys. Res. Commun. (2005)
- Interleukin-18 secretion and Th1-like cytokine responses in human peripheral blood mononuclear cells under the influence of the toll-like receptor-5 ligand flagellin. Bachmann, M., Horn, K., Poleganov, M.A., Paulukat, J., Nold, M., Pfeilschifter, J., Mühl, H. Cell. Microbiol. (2006)
- A surface amebic cysteine proteinase inactivates interleukin-18. Que, X., Kim, S.H., Sajid, M., Eckmann, L., Dinarello, C.A., McKerrow, J.H., Reed, S.L. Infect. Immun. (2003)
- Molluscum contagiosum virus interleukin-18 (IL-18) binding protein is secreted as a full-length form that binds cell surface glycosaminoglycans through the C-terminal tail and a furin-cleaved form with only the IL-18 binding domain. Xiang, Y., Moss, B. J. Virol. (2003)
- Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells. Puren, A.J., Fantuzzi, G., Gu, Y., Su, M.S., Dinarello, C.A. J. Clin. Invest. (1998)
- Stabilization of IFN-gamma mRNA by MAPK p38 in IL-12- and IL-18-stimulated human NK cells. Mavropoulos, A., Sully, G., Cope, A.P., Clark, A.R. Blood (2005)
- Association of interleukin-18 expression with enhanced levels of both interleukin-1beta and tumor necrosis factor alpha in knee synovial tissue of patients with rheumatoid arthritis. Joosten, L.A., Radstake, T.R., Lubberts, E., van den Bersselaar, L.A., van Riel, P.L., van Lent, P.L., Barrera, P., van den Berg, W.B. Arthritis Rheum. (2003)
- Functional reconstitution and regulation of IL-18 activity by the IL-18R beta chain. Kim, S.H., Reznikov, L.L., Stuyt, R.J., Selzman, C.H., Fantuzzi, G., Hoshino, T., Young, H.A., Dinarello, C.A. J. Immunol. (2001)
- Interleukin-18 induces angiogenic factors in rheumatoid arthritis synovial tissue fibroblasts via distinct signaling pathways. Amin, M.A., Mansfield, P.J., Pakozdi, A., Campbell, P.L., Ahmed, S., Martinez, R.J., Koch, A.E. Arthritis Rheum. (2007)
- Impaired interferon-gamma production as a consequence of STAT4 deficiency after autologous hematopoietic stem cell transplantation for lymphoma. Robertson, M.J., Chang, H.C., Pelloso, D., Kaplan, M.H. Blood (2005)
- Beneficial effect of short-term exposure of human NK cells to IL15/IL12 and IL15/IL18 on cell apoptosis and function. Sotiriadou, N.N., Perez, S.A., Gritzapis, A.D., Mahaira, L.G., Salagianni, M., Baxevanis, C.N., Papamichail, M. Cell. Immunol. (2005)
- Evaluation of absolute quantitation by nonlinear regression in probe-based real-time PCR. Goll, R., Olsen, T., Cui, G., Florholmen, J. BMC Bioinformatics (2006)