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Gene Review

IMPDH2  -  IMP (inosine 5'-monophosphate)...

Homo sapiens

Synonyms: IMP dehydrogenase 2, IMPD 2, IMPD2, IMPDH 2, IMPDH-II, ...
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Disease relevance of IMPDH2


High impact information on IMPDH2

  • We evaluated a selection scheme based on the expression of a variant of inosine monophosphate dehydrogenase 2 (IMPDH2), the rate-limiting enzyme in the de novo purine biosynthesis pathway [4].
  • IMPDH 2 messenger RNA (mRNA) and IMPDH protein were both regulated reciprocally by changes in levels of their end-products [5].
  • One of these metabolites (M-2), identified as an acyl glucuronide of MPA, was found to inhibit IMPDH-II in vitro [6].
  • Assignment1 of inosine '-monophosphate dehydrogenase type 2 (IMPDH2) to human chromosome band 3p21.2 by in situ hybridization [7].
  • Among the differentially expressed genes we chose for further validation were inosine monophosphate dehydrogenase type II (IMPDH2), inosine monophosphate cyclohydrolase and survivin as up-regulated genes, and topoisomerase I (TOP1) and vimentin as down-regulated genes [1].

Biological context of IMPDH2


Anatomical context of IMPDH2


Associations of IMPDH2 with chemical compounds


Other interactions of IMPDH2


Analytical, diagnostic and therapeutic context of IMPDH2


  1. Modulation of IMPDH2, survivin, topoisomerase I and vimentin increases sensitivity to methotrexate in HT29 human colon cancer cells. Peñuelas, S., Noé, V., Ciudad, C.J. FEBS J. (2005) [Pubmed]
  2. ZNRD1 mediates resistance of gastric cancer cells to methotrexate by regulation of IMPDH2 and Bcl-2. Hong, L., Qiao, T., Han, Y., Han, S., Zhang, X., Lin, T., Gao, J., Zhao, P., Chen, Z., Fan, D. Biochem. Cell Biol. (2006) [Pubmed]
  3. An exploratory study on pharmacogenetics of inosine-monophosphate dehydrogenase II in peripheral mononuclear cells from liver-transplant recipients. Vannozzi, F., Filipponi, F., Di Paolo, A., Danesi, R., Urbani, L., Bocci, G., Catalano, G., De Simone, P., Mosca, F., Del Tacca, M. Transplant. Proc. (2004) [Pubmed]
  4. Ex vivo selection and expansion of cells based on expression of a mutated inosine monophosphate dehydrogenase 2 after HIV vector transduction: effects on lymphocytes, monocytes, and CD34+ stem cells. Yam, P., Jensen, M., Akkina, R., Anderson, J., Villacres, M.C., Wu, J., Zaia, J.A., Yee, J.K. Mol. Ther. (2006) [Pubmed]
  5. Inosine-5'-monophosphate dehydrogenase is required for mitogenic competence of transformed pancreatic beta cells. Metz, S., Holland, S., Johnson, L., Espling, E., Rabaglia, M., Segu, V., Brockenbrough, J.S., Tran, P.O. Endocrinology (2001) [Pubmed]
  6. Pharmacokinetic and metabolic investigations of mycophenolic acid in pediatric patients after renal transplantation: implications for therapeutic drug monitoring. German Study Group on Mycophenolate Mofetil Therapy in Pediatric Renal Transplant Recipients. Oellerich, M., Shipkova, M., Schütz, E., Wieland, E., Weber, L., Tönshoff, B., Armstrong, V.W. Therapeutic drug monitoring. (2000) [Pubmed]
  7. Assignment1 of inosine '-monophosphate dehydrogenase type 2 (IMPDH2) to human chromosome band 3p21.2 by in situ hybridization. Kost-Alimova, M.V., Glesne, D.A., Huberman, E., Zelenin, A.V. Cytogenet. Cell Genet. (1998) [Pubmed]
  8. Chromosomal localization and structure of the human type II IMP dehydrogenase gene (IMPDH2). Glesne, D., Collart, F., Varkony, T., Drabkin, H., Huberman, E. Genomics (1993) [Pubmed]
  9. Proteomic Analysis of Mitochondria-to-Nucleus Retrograde Response in Human Cancer. Kulawiec, M., Arnouk, H., Desouki, M.M., Kazim, L., Still, I., Singh, K.K. Cancer Biol. Ther. (2006) [Pubmed]
  10. Sensitization of human erythroleukemia K562 cells resistant to methotrexate by inhibiting IMPDH. Peñuelas, S., Noé, V., Morales, R., Ciudad, C.J. Med. Sci. Monit. (2005) [Pubmed]
  11. A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity. Wang, J., Zeevi, A., Webber, S., Girnita, D.M., Addonizio, L., Selby, R., Hutchinson, I.V., Burckart, G.J. Pharmacogenet. Genomics (2007) [Pubmed]
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