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Gene Review

Sin3A  -  CG8815 gene product from transcript CG8815-RC

Drosophila melanogaster

Synonyms: 159A11T, 27/3, 97/15, CG8815, Dmel\CG8815, ...
 
 
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High impact information on Sin3A

  • Chromosomal localization links the SIN3-RPD3 complex to the regulation of chromatin condensation, histone acetylation and gene expression [1].
  • The SIN3/RPD3 deacetylase complex is essential for G(2) phase cell cycle progression and regulation of SMRTER corepressor levels [2].
  • Loss of SIN3 does not affect global acetylation of histones H3 and H4, suggesting that the G(2) phase delay is due not to global changes in genome integrity but rather to derepression of SIN3 target genes [2].
  • We further show that the self-inhibitory domain of Bcd can interact with Sin3A, a component of the histone deacetylase co-repressor complex [3].
  • Presumably, developmental and cellular phenotypes resulting from mutations in SIN3 are a consequence of altered transcription of SIN3 target genes [4].
 

Biological context of Sin3A

  • The identified genes are distributed throughout euchromatic regions but are preferentially excluded from heterochromatic regions of Drosophila chromosomes suggesting that the SIN3 complex can only access particular chromatin structures [4].
  • The SIN3 deacetylase complex represses genes encoding mitochondrial proteins: implications for the regulation of energy metabolism [4].
  • We have cloned a Drosophila homolog of Sin3 (dSin3) and found it to be ubiquitously expressed during embryonic development [5].
 

Analytical, diagnostic and therapeutic context of Sin3A

References

 
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