Gene Review:
PDX1 - pancreatic and duodenal homeobox 1
Homo sapiens
Synonyms:
GSF, Glucose-sensitive factor, IDX-1, IPF-1, IPF1, ...
Swift,
Liu,
Rose,
Bischof,
Steelman,
Buchberg,
Wright,
MacDonald,
Ferber,
Karim,
Wang,
Hale,
Elbein,
Gragnoli,
Stanojevic,
Gorini,
Von Preussenthal,
Thomas,
Habener,
Cockburn,
Bermano,
Boodram,
Teelucksingh,
Tsuchiya,
Mahabir,
Allan,
Stein,
Docherty,
Bell,
Yue,
Cui,
Johkura,
Ogiwara,
Sasaki,
Schwitzgebel,
Mamin,
Brun,
Ritz-Laser,
Zaiko,
Maret,
Jornayvaz,
Theintz,
Michielin,
Melloul,
Philippe,
Elbein,
Wang,
Karim,
Freedman,
Bowden,
Shuldiner,
Brancati,
Kao,
Baier,
Permana,
Traurig,
Dobberfuhl,
Wiedrich,
Sutherland,
Thuillez,
Luczy-Bachman,
Hara,
Horikawa,
Hinokio,
Hanson,
Bogardus,
- Genetic variation in the hepatocyte nuclear factor-3beta gene (HNF3B) does not contribute to maturity-onset diabetes of the young in French Caucasians. Abderrahmani, A., Chèvre, J.C., Otabe, S., Chikri, M., Hani, E.H., Vaxillaire, M., Hinokio, Y., Horikawa, Y., Bell, G.I., Froguel, P. Diabetes (2000)
- IPF-1/MODY4 gene missense mutation in an Italian family with type 2 and gestational diabetes. Gragnoli, C., Stanojevic, V., Gorini, A., Von Preussenthal, G.M., Thomas, M.K., Habener, J.F. Metab. Clin. Exp. (2005)
- Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach. Fodor, A., Harel, C., Fodor, L., Armoni, M., Salmon, P., Trono, D., Karnieli, E. Diabetologia (2007)
- Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood. Hui, H., Perfetti, R. Eur. J. Endocrinol. (2002)
- Transcription factors contributing to the pancreatic beta-cell phenotype. Madsen, O.D., Jensen, J., Petersen, H.V., Pedersen, E.E., Oster, A., Andersen, F.G., Jørgensen, M.C., Jensen, P.B., Larsson, L.I., Serup, P. Horm. Metab. Res. (1997)
- Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Stoffers, D.A., Zinkin, N.T., Stanojevic, V., Clarke, W.L., Habener, J.F. Nat. Genet. (1997)
- Early-onset type-II diabetes mellitus (MODY4) linked to IPF1. Stoffers, D.A., Ferrer, J., Clarke, W.L., Habener, J.F. Nat. Genet. (1997)
- Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes. Macfarlane, W.M., Frayling, T.M., Ellard, S., Evans, J.C., Allen, L.I., Bulman, M.P., Ayres, S., Shepherd, M., Clark, P., Millward, A., Demaine, A., Wilkin, T., Docherty, K., Hattersley, A.T. J. Clin. Invest. (1999)
- Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus. Hani, E.H., Stoffers, D.A., Chèvre, J.C., Durand, E., Stanojevic, V., Dina, C., Habener, J.F., Froguel, P. J. Clin. Invest. (1999)
- Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells. Harmon, J.S., Stein, R., Robertson, R.P. J. Biol. Chem. (2005)
- Mutations in the genes for hepatocyte nuclear factor (HNF)-1alpha, -4alpha, -1beta, and -3beta; the dimerization cofactor of HNF-1; and insulin promoter factor 1 are not common causes of early-onset type 2 diabetes in Pima Indians. Baier, L.J., Permana, P.A., Traurig, M., Dobberfuhl, A., Wiedrich, C., Sutherland, J., Thuillez, P., Luczy-Bachman, G., Hara, M., Horikawa, Y., Hinokio, Y., Hanson, R.L., Bogardus, C. Diabetes Care (2000)
- Can we create new organs from our own tissues? Ferber, S. Isr. Med. Assoc. J. (2000)
- Insulin promoter factor-1 mutations and diabetes in Trinidad: identification of a novel diabetes-associated mutation (E224K) in an Indo-Trinidadian family. Cockburn, B.N., Bermano, G., Boodram, L.L., Teelucksingh, S., Tsuchiya, T., Mahabir, D., Allan, A.B., Stein, R., Docherty, K., Bell, G.I. J. Clin. Endocrinol. Metab. (2004)
- Agenesis of human pancreas due to decreased half-life of insulin promoter factor 1. Schwitzgebel, V.M., Mamin, A., Brun, T., Ritz-Laser, B., Zaiko, M., Maret, A., Jornayvaz, F.R., Theintz, G.E., Michielin, O., Melloul, D., Philippe, J. J. Clin. Endocrinol. Metab. (2003)
- Localization of human homeodomain transcription factor insulin promoter factor 1 (IPF1) to chromosome band 13q12.1. Stoffel, M., Stein, R., Wright, C.V., Espinosa, R., Le Beau, M.M., Bell, G.I. Genomics (1995)
- Insulin Promoter Factor 1 variation is associated with type 2 diabetes in African Americans. Karim, M.A., Wang, X., Hale, T.C., Elbein, S.C. BMC Med. Genet. (2005)
- Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development. Annicotte, J.S., Fayard, E., Swift, G.H., Selander, L., Edlund, H., Tanaka, T., Kodama, T., Schoonjans, K., Auwerx, J. Mol. Cell. Biol. (2003)
- Analysis of FOXO1A as a candidate gene for type 2 diabetes. Karim, M.A., Craig, R.L., Wang, X., Hale, T.C., Elbein, S.C. Mol. Genet. Metab. (2006)
- Identification of cis- and trans-active factors regulating human islet amyloid polypeptide gene expression in pancreatic beta-cells. Carty, M.D., Lillquist, J.S., Peshavaria, M., Stein, R., Soeller, W.C. J. Biol. Chem. (1997)
- Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor. Waeber, G., Thompson, N., Nicod, P., Bonny, C. Mol. Endocrinol. (1996)
- Identification of a novel PDX-1 binding site in the human insulin gene enhancer. Le Lay, J., Matsuoka, T.A., Henderson, E., Stein, R. J. Biol. Chem. (2004)
- Role of a Proline Insertion in the Insulin Promoter Factor 1 (IPF1) Gene in African Americans With Type 2 Diabetes. Elbein, S.C., Wang, X., Karim, M.A., Freedman, B.I., Bowden, D.W., Shuldiner, A.R., Brancati, F.L., Kao, W.H. Diabetes (2006)
- Suppression of transcription factor PDX-1/IPF1/STF-1/IDX-1 causes no decrease in insulin mRNA in MIN6 cells. Kajimoto, Y., Watada, H., Matsuoka, T., Kaneto, H., Fujitani, Y., Miyazaki, J., Yamasaki, Y. J. Clin. Invest. (1997)
- Comparative analysis of insulin gene promoters: implications for diabetes research. Hay, C.W., Docherty, K. Diabetes (2006)
- Insulin upstream factor 1 and a novel ubiquitous factor bind to the human islet amyloid polypeptide/amylin gene promoter. Bretherton-Watt, D., Gore, N., Boam, D.S. Biochem. J. (1996)
- Exendin-4 differentiation of a human pancreatic duct cell line into endocrine cells: involvement of PDX-1 and HNF3beta transcription factors. Zhou, J., Pineyro, M.A., Wang, X., Doyle, M.E., Egan, J.M. J. Cell. Physiol. (2002)
- Transcriptional regulation of the lactase-phlorizin hydrolase promoter by PDX-1. Wang, Z., Fang, R., Olds, L.C., Sibley, E. Am. J. Physiol. Gastrointest. Liver Physiol. (2004)
- The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells. Macfarlane, W.M., Smith, S.B., James, R.F., Clifton, A.D., Doza, Y.N., Cohen, P., Docherty, K. J. Biol. Chem. (1997)
- An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2). Swift, G.H., Liu, Y., Rose, S.D., Bischof, L.J., Steelman, S., Buchberg, A.M., Wright, C.V., MacDonald, R.J. Mol. Cell. Biol. (1998)
- Glucagon-like peptide-1 differentiation of primate embryonic stem cells into insulin-producing cells. Yue, F., Cui, L., Johkura, K., Ogiwara, N., Sasaki, K. Tissue Eng. (2006)
- Enriched human pancreatic ductal cultures obtained from selective death of acinar cells express pancreatic and duodenal homeobox gene-1 age-dependently. Street, C.N., Lakey, J.R., Rajotte, R.V., Shapiro, A.M., Kieffer, T.J., Lyon, J.G., Kin, T., Korbutt, G.S. The review of diabetic studies : RDS (2004)
- The pancreatic homeodomain transcription factor IDX1/IPF1 is expressed in neural cells during brain development. Perez-Villamil, B., Schwartz, P.T., Vallejo, M. Endocrinology (1999)
- Adult human cytokeratin 19-positive cells reexpress insulin promoter factor 1 in vitro: further evidence for pluripotent pancreatic stem cells in humans. Gmyr, V., Kerr-Conte, J., Belaich, S., Vandewalle, B., Leteurtre, E., Vantyghem, M.C., Lecomte-Houcke, M., Proye, C., Lefebvre, J., Pattou, F. Diabetes (2000)