Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene: tum - tumbleweed

Drosophila melanogaster

Synonyms: 13345, AcGAP, CG13345, DRacGAP, enhancer of naked, eon, i249, RacGAP, RacGap50C, RacGAP50C, RhoGAP-50C14

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Goldstein, A.Y., Jones, W.M., Hoemann, C.D., Sotillos, S., Somers, W.G., et al.

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High impact information on RacGAP50C

Similar genetic evidence indicates that RacGAP50C inhibits Rac during cytokinesis [1].
Taken together with previous studies of RacGAP50C in regulating cytokinesis, we propose that Tum serves as a scaffolding protein in regulating cell division but acts as a GAP to limit axon growth in postmitotic neurons [2].
Function and regulation of Tumbleweed (RacGAP50C) in neuroblast proliferation and neuronal morphogenesis [2].
We report here that RacGAP50C corresponds to the tumbleweed (tum) gene previously identified based on its defects in dendrite development of sensory neurons [Gao, F. B., Brenman, J. E., Jan, L. Y. & Jan, Y. N. (1999) Genes Dev. 13, 2549-2561] [2].
Tum/RacGAP50C provides a critical link between anaphase microtubules and the assembly of the contractile ring in Drosophila melanogaster [3].

Biological context of RacGAP50C

These phenotypes suggest that the RacGap50C gene product participates in the negative regulation of Wg pathway activity [4].
RacGap50C negatively regulates wingless pathway activity during Drosophila embryonic development [4].
Reduced function of DRacGAP or increased expression of DRac1 in the wing imaginal disc cause similar effects on vein and sensory organ development and cell proliferation [5].

Anatomical context of RacGAP50C

Pebble regulates actomyosin organization, while RacGAP50C and its binding partner, the Pavarotti kinesin-like protein, regulate microtubule bundling [6].

Other interactions of RacGAP50C

Two mutant lines that modify wg-mediated epidermal patterning represent the first loss-of-function mutations in the RacGap50C gene [4].
Only one RacGAP protein, RnRacGAP, has been identified in Drosophila [7].
Cellular studies have shown that RacGAP proteins function as negative regulators of substrate Rac proteins which, in turn, control the localization and polymerization state of actin within the cell [8].

References

Mutations in sticky lead to defective organization of the contractile ring during cytokinesis and are enhanced by Rho and suppressed by Rac. D'Avino, P.P., Savoian, M.S., Glover, D.M. J. Cell Biol. (2004)
Function and regulation of Tumbleweed (RacGAP50C) in neuroblast proliferation and neuronal morphogenesis. Goldstein, A.Y., Jan, Y.N., Luo, L. Proc. Natl. Acad. Sci. U.S.A. (2005)
Tum/RacGAP50C provides a critical link between anaphase microtubules and the assembly of the contractile ring in Drosophila melanogaster. Zavortink, M., Contreras, N., Addy, T., Bejsovec, A., Saint, R. J. Cell. Sci. (2005)
RacGap50C negatively regulates wingless pathway activity during Drosophila embryonic development. Jones, W.M., Bejsovec, A. Genetics (2005)
DRacGAP, a novel Drosophila gene, inhibits EGFR/Ras signalling in the developing imaginal wing disc. Sotillos, S., Campuzano, S. Development (2000)
A RhoGEF and Rho family GTPase-activating protein complex links the contractile ring to cortical microtubules at the onset of cytokinesis. Somers, W.G., Saint, R. Dev. Cell (2003)
Overexpression of RnRacGAP in Drosophila melanogaster deregulates cytoskeletal organisation in cellularising embryos and induces discrete imaginal phenotypes. Guichard, A., Bergeret, E., Griffin-Shea, R. Mech. Dev. (1997)
Alternative splicing of the Drosophila melanogaster rotundRacGAP gene. Hoemann, C.D., Bergeret, E., Guichard, A., Griffin-Shea, R. Gene (1996)