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Gene Review: 

Arf51F  -  ADP ribosylation factor 51F

Drosophila melanogaster

Synonyms: ADP-ribosylation factor 3, AFR51F, ARF3, ARF6, ARFIII, ...
 
 
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High impact information on Arf51F

  • Accordingly, a dominant-negative ARF6 disrupts myoblast fusion in Drosophila embryos and in mammalian myoblasts in culture, mimicking the fusion defects caused by loss of Loner [1].
  • Control of myoblast fusion by a guanine nucleotide exchange factor, loner, and its effector ARF6 [1].
  • A paper by Chen et al. published in the September 19 issue of Cell adds ARF6, a GTPase, and one of its guanine nucleotide exchange factors to this set of players [2].

References

  1. Control of myoblast fusion by a guanine nucleotide exchange factor, loner, and its effector ARF6. Chen, E.H., Pryce, B.A., Tzeng, J.A., Gonzalez, G.A., Olson, E.N. Cell (2003) [Pubmed]
  2. Myoblasts fuse when loner meets ARF6. Donaldson, J.G. Dev. Cell (2003) [Pubmed]
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