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Gene Review: 

Eip55E  -  CG5345 gene product from transcript CG5345-RA

Drosophila melanogaster

Synonyms: CG5345, Dmel\CG5345, EIP40, Eip40, Eip55BD
 
 
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High impact information on Eip55E

  • In the Drosophila melanogaster cell line Kc-H, ecdysteroid hormone treatment causes increased relative synthesis of three ecdysteroid-inducible polypeptides (EIPs), named according to their molecular weights (in kilodaltons) EIP 40, EIP 29 and EIP 28 [1].
  • Tissue-specific ecdysone responses: regulation of the Drosophila genes Eip28/29 and Eip40 during larval development [2].
  • Eip40 appears to be ecdysone-inducible only in the lymph gland and there only at the premetamorphic peak [2].
  • The Drosophila genes Eip28/29 and Eip40 are expressed in Kc cells and are rapidly induced by the steroid hormone ecdysone [2].
  • Treating Drosophila Kc tissue culture cells with 20-hydroxyecdysone (20E) causes a rapid 10-fold increase in the synthesis of three polypeptides, with molecular weights of 28 kD, 29 kD, and 40 kD (named EIP28, EIP29, and EIP 40, in reference to their molecular weights), as shown by Savakis et al [3].

References

  1. Ecdysteroid-inducible polypeptides in a Drosophila cell line. Savakis, C., Demetri, G., Cherbas, P. Cell (1980) [Pubmed]
  2. Tissue-specific ecdysone responses: regulation of the Drosophila genes Eip28/29 and Eip40 during larval development. Andres, A.J., Cherbas, P. Development (1992) [Pubmed]
  3. Overlapping antiparallel transcripts induced by ecdysone in a Drosophila cell line. Rebers, J. Insect Biochem. Mol. Biol. (1999) [Pubmed]
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