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Gene Review

PSEN1  -  presenilin 1

Gallus gallus

 
 
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High impact information on PSEN1

  • Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1 [1].
  • This gut-specific extramedullary granulopoietic process is reported for the first time in the chick, and is supported by beta-defensin and presenilin 1 gene expression [2].
  • Identification of the presenilins in hematopoietic cells with localization of presenilin 1 to neutrophil and platelet granules [3].
  • These studies indicate that PS1 may play multiple roles in blood cell physiology and that blood tissue may provide a model to study PS1 interactions with other proteins [3].
  • In platelets, PS1 colocalized with glucose transporter (GLUT-3) in the membrane of alpha granules, as evidenced by immunogold electron microscopy [3].
 

Anatomical context of PSEN1

 

Analytical, diagnostic and therapeutic context of PSEN1

  • ActN1 was detected by immunohistochemistry using an antibody that specifically recognizes the processed form of the intracellular domain of Notch1 cleaved by presenilin/gamma-secretase activity [4].

References

  1. Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1. Rubio, M.E., Curcio, C., Chauvet, N., Brusés, J.L. Mol. Cell. Neurosci. (2005) [Pubmed]
  2. Development and adaptations of innate immunity in the gastrointestinal tract of the newly hatched chick. Bar-Shira, E., Friedman, A. Dev. Comp. Immunol. (2006) [Pubmed]
  3. Identification of the presenilins in hematopoietic cells with localization of presenilin 1 to neutrophil and platelet granules. Mirinics, Z.K., Calafat, J., Udby, L., Lovelock, J., Kjeldsen, L., Rothermund, K., Sisodia, S.S., Borregaard, N., Corey, S.J. Blood Cells Mol. Dis. (2002) [Pubmed]
  4. Mapping of notch activation during cochlear development in mice: implications for determination of prosensory domain and cell fate diversification. Murata, J., Tokunaga, A., Okano, H., Kubo, T. J. Comp. Neurol. (2006) [Pubmed]
 
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