Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene: MIA3 - melanoma inhibitory activity family, member 3

Homo sapiens

Synonyms: ARNT, C219-reactive peptide, D320, FLJ21469, FLJ39207, KIAA0268, Melanoma inhibitory activity protein 3 precursor, Protein TANGO, TANGO, UNQ6077, UNQ6077/PRO20088

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Arndt, S., Miller, C.A., Burk, R.D., Moorman, J., Epstein, J.

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Disease relevance of MIA3

These results taken together provide the first indications for a tumor suppressor role of TANGO gene in human malignant melanoma [1].
Myeloma and bone disease: "the dangerous tango" [2].

High impact information on MIA3

Tryptophan, indole, indole acetic acid, and tryptamine activated transcription in yeast coexpressing AHR and ARNT (EC50 values approximately 300 microM) [3].
Functional assays with TANGO transfected or treated cell lines revealed that TANGO expression reduces motility, whereas reduction of TANGO enhances migration [1].
In our study we revealed that TANGO was downregulated or lost in 9 melanoma cell lines when compared to normal melanocytes and in most of the 8 tumor samples analyzed [1].
Dipyrone (metamizole) use in the United States: a lethal tango [4]?
The tango and tangle of human papillomavirus and the human genome [5].

Associations of MIA3 with chemical compounds

Yeast expressing AHR and ARNT displayed constitutive transcriptional activity that was not augmented by addition of AHR agonists in strains that required exogenous tryptophan for viability [3].

References

TANGO is a tumor suppressor of malignant melanoma. Arndt, S., Bosserhoff, A.K. Int. J. Cancer (2006)
Myeloma and bone disease: "the dangerous tango". Epstein, J., Walker, R. Clinical advances in hematology & oncology : H&O (2006)
Expression of the human aryl hydrocarbon receptor complex in yeast. Activation of transcription by indole compounds. Miller, C.A. J. Biol. Chem. (1997)
Dipyrone (metamizole) use in the United States: a lethal tango? Moorman, J. South. Med. J. (2006)
The tango and tangle of human papillomavirus and the human genome. Burk, R.D., DeSalle, R. J. Natl. Cancer Inst. (2006)

Gene: MIA3 - melanoma inhibitory activity family, member 3

Homo sapiens

Disease relevance of MIA3

High impact information on MIA3

Associations of MIA3 with chemical compounds

References

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