Gene Review:
KCNK2 - potassium channel, two pore domain...
Homo sapiens
Synonyms:
K2p2.1, Outward rectifying potassium channel protein TREK-1, Potassium channel subfamily K member 2, TPKC1, TREK, ...
- Regulation of recombinant human brain tandem P domain K+ channels by hypoxia: a role for O2 in the control of neuronal excitability? Kemp, P.J., Peers, C., Lewis, A., Miller, P. J. Cell. Mol. Med. (2004)
- Polymodal regulation of hTREK1 by pH, arachidonic acid, and hypoxia: physiological impact in acidosis and alkalosis. Miller, P., Peers, C., Kemp, P.J. Am. J. Physiol., Cell Physiol. (2004)
- Rapid detection of microorganisms in blood cultures of newborn infants utilizing an automated blood culture system. Garcia-Prats, J.A., Cooper, T.R., Schneider, V.F., Stager, C.E., Hansen, T.N. Pediatrics (2000)
- KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel. Bockenhauer, D., Zilberberg, N., Goldstein, S.A. Nat. Neurosci. (2001)
- Inhalational anesthetics activate two-pore-domain background K+ channels. Patel, A.J., Honoré, E., Lesage, F., Fink, M., Romey, G., Lazdunski, M. Nat. Neurosci. (1999)
- AKAP150, a switch to convert mechano-, pH- and arachidonic acid-sensitive TREK K(+) channels into open leak channels. Sandoz, G., Th??mmler, S., Duprat, F., Feliciangeli, S., Vinh, J., Escoubas, P., Guy, N., Lazdunski, M., Lesage, F. EMBO J. (2006)
- The lipid-activated two-pore domain K+ channel TREK-1 is resistant to hypoxia: implication for ischaemic neuroprotection. Buckler, K.J., Honoré, E. J. Physiol. (Lond.) (2005)
- Comparison of the ESP and BACTEC systems for testing susceptibilities of Mycobacterium tuberculosis complex isolates to pyrazinamide. LaBombardi, V.J. J. Clin. Microbiol. (2002)
- Inhibition of human TREK-1 channels by bupivacaine. Punke, M.A., Licher, T., Pongs, O., Friederich, P. Anesth. Analg. (2003)
- Inhibition of human TREK-1 channels by caffeine and theophylline. Harinath, S., Sikdar, S.K. Epilepsy Res. (2005)
- Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23. Lesage, F., Lazdunski, M. Genomics (1998)
- Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels. Murbartián, J., Lei, Q., Sando, J.J., Bayliss, D.A. J. Biol. Chem. (2005)
- Expression of the mechanosensitive 2PK+ channel TREK-1 in human osteoblasts. Hughes, S., Magnay, J., Foreman, M., Publicover, S.J., Dobson, J.P., El Haj, A.J. J. Cell. Physiol. (2006)
- PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels. Lopes, C.M., Rohács, T., Czirják, G., Balla, T., Enyedi, P., Logothetis, D.E. J. Physiol. (Lond.) (2005)
- Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel. Fink, M., Duprat, F., Lesage, F., Reyes, R., Romey, G., Heurteaux, C., Lazdunski, M. EMBO J. (1996)
- Localization of TASK and TREK, two-pore domain K+ channels, in human cytotrophoblast cells. Bai, X., Greenwood, S.L., Glazier, J.D., Baker, P.N., Sibley, C.P., Taggart, M.J., Fyfe, G.K. J. Soc. Gynecol. Investig. (2005)
- An ACTH- and ATP-regulated background K+ channel in adrenocortical cells is TREK-1. Enyeart, J.J., Xu, L., Danthi, S., Enyeart, J.A. J. Biol. Chem. (2002)
- Molecular and functional properties of two-pore-domain potassium channels. Lesage, F., Lazdunski, M. Am. J. Physiol. Renal Physiol. (2000)
- Inhibition of the human two-pore domain potassium channel, TREK-1, by fluoxetine and its metabolite norfluoxetine. Kennard, L.E., Chumbley, J.R., Ranatunga, K.M., Armstrong, S.J., Veale, E.L., Mathie, A. Br. J. Pharmacol. (2005)
- Deafness associated changes in expression of two-pore domain potassium channels in the rat cochlear nucleus. Holt, A.G., Asako, M., Keith Duncan, R., Lomax, C.A., Juiz, J.M., Altschuler, R.A. Hear. Res. (2006)
- Trichloroethanol enhances the activity of recombinant human TREK-1 and TRAAK channels. Harinath, S., Sikdar, S.K. Neuropharmacology (2004)
- Acute hypoxia occludes hTREK-1 modulation: re-evaluation of the potential role of tandem P domain K+ channels in central neuroprotection. Miller, P., Kemp, P.J., Lewis, A., Chapman, C.G., Meadows, H.J., Peers, C. J. Physiol. (Lond.) (2003)
- Expression of TASK and TREK, two-pore domain K+ channels, in human myometrium. Bai, X., Bugg, G.J., Greenwood, S.L., Glazier, J.D., Sibley, C.P., Baker, P.N., Taggart, M.J., Fyfe, G.K. Reproduction (2005)
- The two-pore-domain K(+) channels TREK-1 and TASK-3 are differentially modulated by copper and zinc. Gruss, M., Mathie, A., Lieb, W.R., Franks, N.P. Mol. Pharmacol. (2004)
- Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2. Gu, W., Schlichthörl, G., Hirsch, J.R., Engels, H., Karschin, C., Karschin, A., Derst, C., Steinlein, O.K., Daut, J. J. Physiol. (Lond.) (2002)