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Gene Review: 

slbo  -  slow border cells

Drosophila melanogaster

 
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High impact information on slbo

 

Biological context of slbo

  • Timely initiation of border cell migration requires the product of the slow border cells (slbo) locus, which encodes the Drosophila homolog of the transcription factor C/EBP [4].
  • Here we identify Drosophila Stat92E (signal transducer and activator of transcription) in a screen for gain-of-function suppressors of the slbo mutant phenotype [5].
  • This fragment also contained three potential half-nuclear factor 1 (NF1) sites (TGGA-NNNNNGCCA) and a putative CCAAT-enhancer binding protein (C/EBP) binding site [6].
 

Other interactions of slbo

  • Furthermore, C/EBP-independent btl expression was able to rescue the migration defects of hypomorphic slbo alleles [4].

References

  1. slow border cells, a locus required for a developmentally regulated cell migration during oogenesis, encodes Drosophila C/EBP. Montell, D.J., Rorth, P., Spradling, A.C. Cell (1992)
  2. The level of C/EBP protein is critical for cell migration during Drosophila oogenesis and is tightly controlled by regulated degradation. Rørth, P., Szabo, K., Texido, G. Mol. Cell (2000)
  3. Jing: a downstream target of slbo required for developmental control of border cell migration. Liu, Y., Montell, D.J. Development (2001)
  4. The breathless FGF receptor homolog, a downstream target of Drosophila C/EBP in the developmental control of cell migration. Murphy, A.M., Lee, T., Andrews, C.M., Shilo, B.Z., Montell, D.J. Development (1995)
  5. The JAK/STAT pathway is required for border cell migration during Drosophila oogenesis. Beccari, S., Teixeira, L., Rørth, P. Mech. Dev. (2002)
  6. Members of the nuclear factor 1 transcription factor family regulate rat 3alpha-hydroxysteroid/dihydrodiol dehydrogenase (3alpha-HSD/DD AKR1C9) gene expression: a member of the aldo-keto reductase superfamily. Hung, C.F., Penning, T.M. Mol. Endocrinol. (1999)
 
 
 
 
 
 
 
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