Psychiatry related information on mth

• The hypotheses tested here were: (i) that the extension of life span by mth might be temperature-dependent, and (ii) that it might be associated with depression of reproductive output, physical activity, or the rate of metabolism [1].

High impact information on mth

• The mth gene predicted a protein with homology to several guanosine triphosphate-binding protein-coupled seven-transmembrane domain receptors [2].
• We conclude that the Stunted-Methuselah system is involved in the control of animal ageing [3].
• Crystal structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan [4].
• Further analysis of single nucleotide polymorphisms (SNPs) in D. melanogaster provided evidence for contemporary and spatially variable selection at the mth locus [5].
• The Drosophila gene methuselah (mth) has been proposed as having major effects on organismal stress response and longevity phenotype [5].

Biological context of mth

• In ten surveyed populations, the most common mth haplotype exhibited a 40% cline in frequency that coincided with population level differences in multiple life-history traits including lifespan [5].
• Here we report the identification and characterization of two endogenous peptide ligands of Methuselah, designated Stunted A and B. Flies with mutations in the gene encoding these ligands show an increase in lifespan and resistance to oxidative stress [3].

Anatomical context of mth

• As Sun has been identified as the ligand for the Methuselah receptor that regulates aging, Sun may function both within and outside mitochondria [6].
• Interestingly, slowing of stem cell division rate was not observed in long-lived methuselah mutant flies [7].

Other interactions of mth

• However, Ka : Ks ratios indicate a difference in levels of functional constraint at the two methuselah, loci with mth2 exhibiting a five- to six-fold reduction in levels of amino acid divergence relative to mth [8].
• The N-terminal Rel homology domain (RHD) of Dl was not sufficient for repression of mth [9].

Analytical, diagnostic and therapeutic context of mth

• Unexpectedly, semi-quantitative RT-PCR analysis revealed that the level of mth transcripts was reduced in dl flies [9].

References