Gene Review:
KLK2 - kallikrein-related peptidase 2
Homo sapiens
Synonyms:
Glandular kallikrein-1, KLK2A2, Kallikrein-2, Tissue kallikrein-2, hGK-1, ...
Slawin,
Shariat,
Nguyen,
Leventis,
Song,
Kattan,
Young,
Tindall,
Wheeler,
Denmeade,
Sokoll,
Dalrymple,
Rosen,
Gady,
Bruzek,
Ricklis,
Isaacs,
Mikolajczyk,
Millar,
Kumar,
Saedi,
Mikolajczyk,
Millar,
Marker,
Grauer,
Goel,
Cass,
Kumar,
Saedi,
Olsson,
Lundwall,
Nam,
Zhang,
Trachtenberg,
Diamandis,
Toi,
Emami,
Ho,
Sweet,
Evans,
Jewett,
Narod,
Sun,
Pan,
Balk,
- The new human kallikrein gene family: implications in carcinogenesis. Diamandis, E.P., Yousef, G.M., Luo, L.Y., Magklara, A., Obiezu, C.V. Trends Endocrinol. Metab. (2000)
- Down-regulation of the human kallikrein gene 5 (KLK5) in prostate cancer tissues. Yousef, G.M., Scorilas, A., Chang, A., Rendl, L., Diamandis, M., Jung, K., Diamandis, E.P. Prostate (2002)
- Immunoreactivity of recombinant human glandular kallikrein using monoclonal antibodies raised against prostate-specific antigen. Eerola, R., Piironen, T., Pettersson, K., Lövgren, J., Vehniäinen, M., Lilja, H., Dowell, B., Lövgren, T., Karp, M. Prostate (1997)
- Robust prostate-specific expression for targeted gene therapy based on the human kallikrein 2 promoter. Xie, X., Zhao, X., Liu, Y., Young, C.Y., Tindall, D.J., Slawin, K.M., Spencer, D.M. Hum. Gene Ther. (2001)
- Tissue-specific and hormonal regulation of human prostate-specific glandular kallikrein. Young, C.Y., Andrews, P.E., Montgomery, B.T., Tindall, D.J. Biochemistry (1992)
- Human glandular kallikrein as a tool to improve discrimination of poorly differentiated and non-organ-confined prostate cancer compared with prostate-specific antigen. Recker, F., Kwiatkowski, M.K., Piironen, T., Pettersson, K., Huber, A., Lümmen, G., Tscholl, R. Urology (2000)
- Identification of human glandular kallikrein in the beta cell of the pancreas. ole-MoiYoi, O.K., Pinkus, G.S., Spragg, J., Austen, K.F. N. Engl. J. Med. (1979)
- Locus-wide chromatin remodeling and enhanced androgen receptor-mediated transcription in recurrent prostate tumor cells. Jia, L., Shen, H.C., Wantroba, M., Khalid, O., Liang, G., Wang, Q., Gentzschein, E., Pinski, J.K., Stanczyk, F.Z., Jones, P.A., Coetzee, G.A. Mol. Cell. Biol. (2006)
- EZC-prostate models offer high sensitivity and specificity for noninvasive imaging of prostate cancer progression and androgen receptor action. Seethammagari, M.R., Xie, X., Greenberg, N.M., Spencer, D.M. Cancer Res. (2006)
- Single nucleotide polymorphism of the human kallikrein-2 gene highly correlates with serum human kallikrein-2 levels and in combination enhances prostate cancer detection. Nam, R.K., Zhang, W.W., Trachtenberg, J., Diamandis, E., Toi, A., Emami, M., Ho, M., Sweet, J., Evans, A., Jewett, M.A., Narod, S.A. J. Clin. Oncol. (2003)
- Dissociation between androgen responsiveness for malignant growth vs. expression of prostate specific differentiation markers PSA, hK2, and PSMA in human prostate cancer models. Denmeade, S.R., Sokoll, L.J., Dalrymple, S., Rosen, D.M., Gady, A.M., Bruzek, D., Ricklis, R.M., Isaacs, J.T. Prostate (2003)
- Expression of human prostate-specific glandular kallikrein protein (hK2) in the breast cancer cell line T47-D. Hsieh, M.L., Charlesworth, M.C., Goodmanson, M., Zhang, S., Seay, T., Klee, G.G., Tindall, D.J., Young, C.Y. Cancer Res. (1997)
- Concentrations of glandular kallikrein in human nasal secretions increase during experimentally induced allergic rhinitis. Baumgarten, C.R., Nichols, R.C., Naclerio, R.M., Proud, D. J. Immunol. (1986)
- Estrogen and tamoxifen interplay with T(3) in male rats: pharmacologically distinct classes of estrogen responses affecting growth, bone, and lipid metabolism, and their relation to serum GH and IGF-I. Fitts, J.M., Klein, R.M., Powers, C.A. Endocrinology (2001)
- Human kallikrein 11: a new biomarker of prostate and ovarian carcinoma. Diamandis, E.P., Okui, A., Mitsui, S., Luo, L.Y., Soosaipillai, A., Grass, L., Nakamura, T., Howarth, D.J., Yamaguchi, N. Cancer Res. (2002)
- Unusual alternative splicing within the human kallikrein genes KLK2 and KLK3 gives rise to novel prostate-specific proteins. David, A., Mabjeesh, N., Azar, I., Biton, S., Engel, S., Bernstein, J., Romano, J., Avidor, Y., Waks, T., Eshhar, Z., Langer, S.Z., Lifschitz-Mercer, B., Matzkin, H., Rotman, G., Toporik, A., Savitsky, K., Mintz, L. J. Biol. Chem. (2002)
- Androgen receptor-associated protein complex binds upstream of the androgen-responsive elements in the promoters of human prostate-specific antigen and kallikrein 2 genes. Sun, Z., Pan, J., Balk, S.P. Nucleic Acids Res. (1997)
- Identifying the combination of the transcriptional regulatory sequences on prostate specific antigen and human glandular kallikrein genes. Tsui, K.H., Wu, L., Chang, P.L., Hsieh, M.L., Juang, H.H. J. Urol. (2004)
- Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. Gan, L., Lee, I., Smith, R., Argonza-Barrett, R., Lei, H., McCuaig, J., Moss, P., Paeper, B., Wang, K. Gene (2000)
- Glandular kallikreins and prostate-specific antigen are expressed in the human endometrium. Clements, J., Mukhtar, A. J. Clin. Endocrinol. Metab. (1994)
- Expression of the kallikrein gene family in normal and Alzheimer's disease brain. Shimizu-Okabe, C., Yousef, G.M., Diamandis, E.P., Yoshida, S., Shiosaka, S., Fahnestock, M. Neuroreport (2001)
- Expression of human glandular kallikrein, hK2, in mammalian cells. Kumar, A., Goel, A.S., Hill, T.M., Mikolajczyk, S.D., Millar, L.S., Kuus-Reichel, K., Saedi, M.S. Cancer Res. (1996)
- Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2. Bourgeois, L., Brillard-Bourdet, M., Deperthes, D., Juliano, M.A., Juliano, L., Tremblay, R.R., Dubé, J.Y., Gauthier, F. J. Biol. Chem. (1997)
- Coregulator recruitment and histone modifications in transcriptional regulation by the androgen receptor. Kang, Z., Jänne, O.A., Palvimo, J.J. Mol. Endocrinol. (2004)
- Steroid-involved transcriptional regulation of human genes encoding prostatic acid phosphatase, prostate-specific antigen, and prostate-specific glandular kallikrein. Shan, J.D., Porvari, K., Ruokonen, M., Karhu, A., Launonen, V., Hedberg, P., Oikarinen, J., Vihko, P. Endocrinology (1997)
- Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1. Mikolajczyk, S.D., Millar, L.S., Kumar, A., Saedi, M.S. Int. J. Cancer (1999)
- Significance and metabolism of complexed and noncomplexed prostate specific antigen forms, and human glandular kallikrein 2 in clinically localized prostate cancer before and after radical prostatectomy. Lilja, H., Haese, A., Björk, T., Friedrich, M.G., Piironen, T., Pettersson, K., Huland, E., Huland, H. J. Urol. (1999)
- Potential involvement of kallikrein hK2 in the hydrolysis of the human seminal vesicle proteins after ejaculation. Deperthes, D., Frenette, G., Brillard-Bourdet, M., Bourgeois, L., Gauthier, F., Tremblay, R.R., Dubé, J.Y. J. Androl. (1996)
- Ala217 is important for the catalytic function and autoactivation of prostate-specific human kallikrein 2. Mikolajczyk, S.D., Millar, L.S., Marker, K.M., Grauer, L.S., Goel, A., Cass, M.M., Kumar, A., Saedi, M.S. Eur. J. Biochem. (1997)
- Prostate-specific antigen and human glandular kallikrein: two kallikreins of the human prostate. Henttu, P., Vihko, P. Ann. Med. (1994)
- Kininogenase activity of prostate-derived human glandular kallikrein (hK2) purified from seminal fluid. Charlesworth, M.C., Young, C.Y., Miller, V.M., Tindall, D.J. J. Androl. (1999)
- Organization and evolution of the glandular kallikrein locus in Mus musculus. Olsson, A.Y., Lundwall, A. Biochem. Biophys. Res. Commun. (2002)
- Kallikrein gene expression in human pituitary tissues. Clements, J.A., Mukhtar, A., Verity, K., Pullar, M., McNeill, P., Cummins, J., Fuller, P.J. Clin. Endocrinol. (Oxf) (1996)
- Detection of metastatic prostate cancer using a splice variant-specific reverse transcriptase-polymerase chain reaction assay for human glandular kallikrein. Slawin, K.M., Shariat, S.F., Nguyen, C., Leventis, A.K., Song, W., Kattan, M.W., Young, C.Y., Tindall, D.J., Wheeler, T.M. Cancer Res. (2000)