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KLRC2  -  killer cell lectin-like receptor subfamily...

Homo sapiens

Synonyms: CD159 antigen-like family member C, CD159c, NK cell receptor C, NKG2-C, NKG2-C type II integral membrane protein, ...
 
 
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Disease relevance of KLRC2

  • These results indicated that NKG2C deletion is commonly present in Japanese and Dutch, suggesting that NKG2C is not essential for survival and reproduction, and is not associated with rheumatic diseases [1].
 

High impact information on KLRC2

  • Association of DAP12 with activating CD94/NKG2C NK cell receptors [2].
  • Molecular analysis reveals that NKG2C and NKG2E messages are extensively alternatively spliced and approximately 20-fold less abundant than NKG2A message in NK cells [3].
  • In most patients NK cells were characterized by the CD94/NKG2A+ phenotype, whereas only a minor fraction of the cases expressed CD94/NKG2C [4].
  • Pt-NKG2CI and Pt-NKG2CII are equally diverged from human NKG2C, indicating that they arose by gene duplication subsequent to the divergence of chimpanzee and human ancestors [5].
  • Altogether these results support that CD94/NKG2C may constitute an alternative T cell activation pathway capable of driving the expansion and triggering the effector functions of a CTL subset [6].
 

Biological context of KLRC2

 

Anatomical context of KLRC2

 

Associations of KLRC2 with chemical compounds

  • NKG2A/B contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) and accordingly functions as an inhibitory receptor, whereas NKG2C and -E/H associate with DAP12 via a positively charged residue in their transmembrane domains and function as activation receptors [12].
  • Evidence of NK cell dysfunction in SIV-infected rhesus monkeys: Impairment of cytokine secretion and NKG2C/C2 expression [13].
  • We show here that NKG2-C is expressed as a 36-kDa glycoprotein by translation in vitro, recombinant expression and immunoprecipitation from a human NK cell clone [14].
 

Physical interactions of KLRC2

 

Regulatory relationships of KLRC2

  • NKG2-D was expressed in nine of fourteen T-cell clones or lines in the panel, whereas NKG2-A/B was expressed in three and NKG2-C was expressed in only one [16].
 

Other interactions of KLRC2

  • Role for NKG2-A and NKG2-C surface receptors in chronic CD4+ T-cell responses [17].
  • NKG2F could be a receptor component with an as yet unidentified partner(s), could function to regulate cell activation through competition for DAP12 with other receptors, such as NKG2C and -E/H, or it could simply be a vestigial gene product [12].
  • When analyzing NK cell clones derived from a single donor we found differential expression of inhibitory (NKG2-A/B) versus triggering (NKG2-C and potentially -E, -F, -H) NK receptor chains [18].
  • This study was performed to identify the breakpoint, and to examine the association of NKG2C deletion with susceptibility to rheumatoid arthritis and systemic lupus erythematosus [1].
 

Analytical, diagnostic and therapeutic context of KLRC2

References

  1. Molecular genetic analyses of human NKG2C (KLRC2) gene deletion. Miyashita, R., Tsuchiya, N., Hikami, K., Kuroki, K., Fukazawa, T., Bijl, M., Kallenberg, C.G., Hashimoto, H., Yabe, T., Tokunaga, K. Int. Immunol. (2004) [Pubmed]
  2. Association of DAP12 with activating CD94/NKG2C NK cell receptors. Lanier, L.L., Corliss, B., Wu, J., Phillips, J.H. Immunity (1998) [Pubmed]
  3. Recognition of the class Ib molecule Qa-1(b) by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells. Vance, R.E., Jamieson, A.M., Raulet, D.H. J. Exp. Med. (1999) [Pubmed]
  4. Expression and function of KIR and natural cytotoxicity receptors in NK-type lymphoproliferative diseases of granular lymphocytes. Zambello, R., Falco, M., Della Chiesa, M., Trentin, L., Carollo, D., Castriconi, R., Cannas, G., Carlomagno, S., Cabrelle, A., Lamy, T., Agostini, C., Moretta, A., Semenzato, G., Vitale, M. Blood (2003) [Pubmed]
  5. Conservation and variation in human and common chimpanzee CD94 and NKG2 genes. Shum, B.P., Flodin, L.R., Muir, D.G., Rajalingam, R., Khakoo, S.I., Cleland, S., Guethlein, L.A., Uhrberg, M., Parham, P. J. Immunol. (2002) [Pubmed]
  6. The CD94/NKG2C killer lectin-like receptor constitutes an alternative activation pathway for a subset of CD8+ T cells. Gumá, M., Busch, L.K., Salazar-Fontana, L.I., Bellosillo, B., Morte, C., García, P., López-Botet, M. Eur. J. Immunol. (2005) [Pubmed]
  7. Mitogen-activated protein kinase activity is involved in effector functions triggered by the CD94/NKG2-C NK receptor specific for HLA-E. Carretero, M., Llano, M., Navarro, F., Bellón, T., López-Botet, M. Eur. J. Immunol. (2000) [Pubmed]
  8. Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population. Hikami, K., Tsuchiya, N., Yabe, T., Tokunaga, K. Genes Immun. (2003) [Pubmed]
  9. The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex. Glienke, J., Sobanov, Y., Brostjan, C., Steffens, C., Nguyen, C., Lehrach, H., Hofer, E., Francis, F. Immunogenetics (1998) [Pubmed]
  10. Expression of CD94/NKG2 subtypes on tumor-infiltrating lymphocytes in primary and metastatic melanoma. Vetter, C.S., Straten, P.T., Terheyden, P., Zeuthen, J., Bröcker, E.B., Becker, J.C. J. Invest. Dermatol. (2000) [Pubmed]
  11. NKG2A and CD56 are coexpressed on activated TH2 but not TH1 lymphocytes. Freishtat, R.J., Mitchell, L.W., Ghimbovschi, S.D., Meyers, S.B., Hoffman, E.P. Hum. Immunol. (2005) [Pubmed]
  12. Human NKG2F is expressed and can associate with DAP12. Kim, D.K., Kabat, J., Borrego, F., Sanni, T.B., You, C.H., Coligan, J.E. Mol. Immunol. (2004) [Pubmed]
  13. Evidence of NK cell dysfunction in SIV-infected rhesus monkeys: Impairment of cytokine secretion and NKG2C/C2 expression. Labonte, M.L., McKay, P.F., Letvin, N.L. Eur. J. Immunol. (2006) [Pubmed]
  14. NKG2-C is a receptor on human natural killer cells that recognizes structures on K562 target cells. Düchler, M., Offterdinger, M., Holzmüller, H., Lipp, J., Chu, C.T., Aschauer, B., Bach, F.H., Hofer, E. Eur. J. Immunol. (1995) [Pubmed]
  15. The CD94/NKG2 C-type lectin receptor complex. López-Botet, M., Carretero, M., Bellón, T., Pérez-Villar, J.J., Llano, M., Navarro, F. Curr. Top. Microbiol. Immunol. (1998) [Pubmed]
  16. A multigene family on human chromosome 12 encodes natural killer-cell lectins. Yabe, T., McSherry, C., Bach, F.H., Fisch, P., Schall, R.P., Sondel, P.M., Houchins, J.P. Immunogenetics (1993) [Pubmed]
  17. Role for NKG2-A and NKG2-C surface receptors in chronic CD4+ T-cell responses. Ortega, C., Romero, P., Palma, A., Orta, T., Peña, J., García-Vinuesa, A., Molina, I.J., Santamaría, M. Immunol. Cell Biol. (2004) [Pubmed]
  18. Differential expression of inhibitory and activating CD94/NKG2 receptors on NK cell clones. Brostjan, C., Bellón, T., Sobanov, Y., López-Botet, M., Hofer, E. J. Immunol. Methods (2002) [Pubmed]
 
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