Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

ASSBSV_gp2 - encodes gag, pro, and pol

Atlantic salmon swim bladder sarcoma virus

Schultz, A.M. et al., Oertle, S. et al., Pachl, C. et al., Scheifele, L.Z. et al.

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Disease relevance of ASSBSV_gp2

Avian retroviruses (with the notable exception of spleen necrosis virus) express their protease (PR) both in their gag and their gag-pol polyprotein precursors, in contrast to other retroviruses, notably, the mammalian retroviruses, in which PR is encoded in the gag-pol polyprotein or in a separate reading frame as a gag-pro product [1].
Complementation studies with Rous sarcoma virus gag and gag-pol polyprotein mutants [1].
In a panel of mammalian type C retroviruses we found that the precursor polyprotein Pr65gag homologs, but not the glycosylated forms (gPr80gag homologs), were specifically labeled after a 5-min incubation of infected cells with [3H]myristic acid [2].
The gag precursor polyprotein was also labeled in mouse mammary tumor virus and in Mason-Pfizer monkey virus, but Pr76gag of Rous sarcoma virus failed to incorporate [3H]myristate [2].

High impact information on ASSBSV_gp2

Using gain-of-function approaches, we found that the hydrophobic motif in p10 was sufficient to promote the nuclear export of a heterologous protein and was positionally independent within the Gag polyprotein [3].
A highly oncogenic MH2 virus variant (MH2YS3) (M. Linial, Virology 119:382-391, 1982) was shown to encode only p57myc and not P100, the previously described MH2-encoded polyprotein (Hu et al., Virology, 89:162-178, 1978) [4].

References

Complementation studies with Rous sarcoma virus gag and gag-pol polyprotein mutants. Oertle, S., Bowles, N., Spahr, P.F. J. Virol. (1992) [Pubmed]
In vivo modification of retroviral gag gene-encoded polyproteins by myristic acid. Schultz, A.M., Oroszlan, S. J. Virol. (1983) [Pubmed]
Detailed mapping of the nuclear export signal in the Rous sarcoma virus Gag protein. Scheifele, L.Z., Ryan, E.P., Parent, L.J. J. Virol. (2005) [Pubmed]
RNA and protein encoded by MH2 virus: evidence for subgenomic expression of v-myc. Pachl, C., Biegalke, B., Linial, M. J. Virol. (1983) [Pubmed]

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