Gene Review:
KRT16 - keratin 16, type I
Homo sapiens
Synonyms:
CK-16, CK16, Cytokeratin-16, FNEPPK, K16, ...
- Novel mutations in keratin 16 gene underly focal non-epidermolytic palmoplantar keratoderma (NEPPK) in two families. Shamsher, M.K., Navsaria, H.A., Stevens, H.P., Ratnavel, R.C., Purkis, P.E., Kelsell, D.P., McLean, W.H., Cook, L.J., Griffiths, W.A., Gschmeissner, S. Hum. Mol. Genet. (1995)
- Keratin 17 is expressed during the course of SLS-induced irritant contact dermatitis, but unlike keratin 16, the degree of expression is unrelated to the density of dividing keratinocytes. Willis, C.M., Reiche, L., Wilkinson, J.D. Contact Derm. (1998)
- Altered phenotype of cultured urothelial and other stratified epithelial cells: implications for wound healing. Sun, T.T. Am. J. Physiol. Renal Physiol. (2006)
- A mutation in the V1 domain of K16 is responsible for unilateral palmoplantar verrucous nevus. Terrinoni, A., Puddu, P., Didona, B., De Laurenzi, V., Candi, E., Smith, F.J., McLean, W.H., Melino, G. J. Invest. Dermatol. (2000)
- Keratin 16 and keratin 17 mutations cause pachyonychia congenita. McLean, W.H., Rugg, E.L., Lunny, D.P., Morley, S.M., Lane, E.B., Swensson, O., Dopping-Hepenstal, P.J., Griffiths, W.A., Eady, R.A., Higgins, C. Nat. Genet. (1995)
- Successful ultraviolet B treatment of psoriasis is accompanied by a reversal of keratinocyte pathology and by selective depletion of intraepidermal T cells. Krueger, J.G., Wolfe, J.T., Nabeya, R.T., Vallat, V.P., Gilleaudeau, P., Heftler, N.S., Austin, L.M., Gottlieb, A.B. J. Exp. Med. (1995)
- PUVA bath therapy strongly suppresses immunological and epidermal activation in psoriasis: a possible cellular basis for remittive therapy. Vallat, V.P., Gilleaudeau, P., Battat, L., Wolfe, J., Nabeya, R., Heftler, N., Hodak, E., Gottlieb, A.B., Krueger, J.G. J. Exp. Med. (1994)
- Gentamicin-resistant Klebsiella aerogenes in a urological ward. Casewell, M.W., Dalton, M.T., Webster, M., Phillips, I. Lancet (1977)
- Normal human urothelial cells in vitro: proliferation and induction of stratification. Southgate, J., Hutton, K.A., Thomas, D.F., Trejdosiewicz, L.K. Lab. Invest. (1994)
- Survival of multiply-resistant Klebsiella aerogenes and other gram-negative bacilli on finger-tips. Casewell, M.W., Desai, N. J. Hosp. Infect. (1983)
- Outbreak of co-trimoxazole- and gentamicin-resistant Klebsiella aerogenes bacteremia in neutropenic patients receiving oral co-trimoxazole prophylaxis. Leahy, M.F., Humble, M.W. Australian and New Zealand journal of medicine. (1983)
- Novel proline substitution mutations in keratin 16 in two cases of pachyonychia congenita type 1. Smith, F.J., Del Monaco, M., Steijlen, P.M., Munro, C.S., Morvay, M., Coleman, C.M., Rietveld, F.J., Uitto, J., McLean, W.H. Br. J. Dermatol. (1999)
- A group of type I keratin genes on human chromosome 17: characterization and expression. Rosenberg, M., RayChaudhury, A., Shows, T.B., Le Beau, M.M., Fuchs, E. Mol. Cell. Biol. (1988)
- Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential role for keratin 16. Paladini, R.D., Takahashi, K., Bravo, N.S., Coulombe, P.A. J. Cell Biol. (1996)
- A proline residue in the alpha-helical rod domain of type I keratin 16 destabilizes keratin heterotetramers. Wawersik, M., Paladini, R.D., Noensie, E., Coulombe, P.A. J. Biol. Chem. (1997)
- Novel keratin 16 mutations and protein expression studies in pachyonychia congenita type 1 and focal palmoplantar keratoderma. Smith, F.J., Fisher, M.P., Healy, E., Rees, J.L., Bonifas, J.M., Epstein, E.H., Tan, E.M., Uitto, J., McLean, W.H. Exp. Dermatol. (2000)
- In situ hybridization study of cytokeratin 4, 13, 16 and 19 mRNAs in human developing junctional epithelium. Feghali-Assaly, M., Sawaf, M.H., Ouhayoun, J.P. Eur. J. Oral Sci. (1997)
- Mutation of a type II keratin gene (K6a) in pachyonychia congenita. Bowden, P.E., Haley, J.L., Kansky, A., Rothnagel, J.A., Jones, D.O., Turner, R.J. Nat. Genet. (1995)
- Control of keratin gene expression by vitamin A in tracheobronchial epithelial cells. Huang, T.H., Ann, D.K., Zhang, Y.J., Chang, A.T., Crabb, J.W., Wu, R. Am. J. Respir. Cell Mol. Biol. (1994)
- Deciphering the Roles of the Histone H2B N-Terminal Domain in Genome-Wide Transcription. Parra, M.A., Kerr, D., Fahy, D., Pouchnik, D.J., Wyrick, J.J. Mol. Cell. Biol. (2006)
- Codominant regulation of keratin gene expression by cell surface receptors and nuclear receptors. Tomić-Canić, M., Freedberg, I.M., Blumenberg, M. Exp. Cell Res. (1996)
- Aberrant integrin expression during epidermal wound healing and in psoriatic epidermis. Hertle, M.D., Kubler, M.D., Leigh, I.M., Watt, F.M. J. Clin. Invest. (1992)
- PTHrP and cytokeratins in human epidermis. Seidel, J., Zabel, M., Kasprzak, A. Folia Histochem. Cytobiol. (2002)
- Activation of extracellular signal-regulated kinase signaling by epidermal growth factor mediates c-Jun activation and p300 recruitment in keratin 16 gene expression. Wang, Y.N., Chen, Y.J., Chang, W.C. Mol. Pharmacol. (2006)
- Modulation of cell proliferation by cytokeratins K10 and K16. Paramio, J.M., Casanova, M.L., Segrelles, C., Mittnacht, S., Lane, E.B., Jorcano, J.L. Mol. Cell. Biol. (1999)
- Differential expression of cytokeratin mRNA and protein in normal prostate, prostatic intraepithelial neoplasia, and invasive carcinoma. Yang, Y., Hao, J., Liu, X., Dalkin, B., Nagle, R.B. Am. J. Pathol. (1997)
- Expression of cytokeratins 13 and 16 in middle ear cholesteatoma. Sasaki, H., Huang, C.C. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (1994)
- A human keratin 10 knockout causes recessive epidermolytic hyperkeratosis. Müller, F.B., Huber, M., Kinaciyan, T., Hausser, I., Schaffrath, C., Krieg, T., Hohl, D., Korge, B.P., Arin, M.J. Hum. Mol. Genet. (2006)
- The epidermal phenotype during initiation of the psoriatic lesion in the symptomless margin of relapsing psoriasis. Castelijns, F.A., Gerritsen, M.J., van Vlijmen-Willems, I.M., van Erp, P.E., van de Kerkhof, P.C. J. Am. Acad. Dermatol. (1999)
- Delayed-onset pachyonychia congenita associated with a novel mutation in the central 2B domain of keratin 16. Connors, J.B., Rahil, A.K., Smith, F.J., McLean, W.H., Milstone, L.M. Br. J. Dermatol. (2001)
- K16 expression in uninvolved psoriatic skin: a possible marker of pre-clinical psoriasis. Bhawan, J., Bansal, C., Whren, K., Schwertschlag, U. J. Cutan. Pathol. (2004)
- A mutation detection strategy for the human keratin 6A gene and novel missense mutations in two cases of pachyonychia congenita type 1. Smith, F.J., McKenna, K.E., Irvine, A.D., Bingham, E.A., Coleman, C.M., Uitto, J., McLean, W.H. Exp. Dermatol. (1999)