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Gene Review

Argk  -  Arginine kinase

Drosophila melanogaster

Synonyms: AK, AK-1, ARK, ArgK, CG32031, ...
 
 
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Disease relevance of Argk

 

High impact information on Argk

  • A recombinant adenovirus was constructed by using the gene for arginine kinase (AK), which is the invertebrate correlate to the vertebrate ATP-buffering enzyme, creatine kinase [1].
  • The product of the AK enzyme, phosphoarginine (PArg), served as an MRS-visible reporter of AK expression [1].
  • Therefore, the cDNA encoding AK provides a useful reporter gene that allows noninvasive and repeated monitoring of gene expression after viral mediated gene transfer to muscle [1].
  • An A-kinase anchoring protein is required for protein kinase A regulatory subunit localization and morphology of actin structures during oogenesis in Drosophila [2].
  • The findings of the present study are discussed in the context of CK and ArgK function in general and of structural and bioenergetic differences between vertebrate striated muscles and arthropod flight muscles [3].
 

Biological context of Argk

  • A homologue of dual phosphatase, cdc25, has not been cloned yet from alfalfa; however tyrosine phosphorylation was indicated in the case of Cdc2Ms A kinase and the p(13suc1)-bound kinase activity was increased by treatment of this complex with recombinant Drosophila Cdc25 [4].
 

Anatomical context of Argk

  • In muscle fibres of third instar larvae and in isolated adult fibrillar flight muscle myofibrils, AK was localized within the Z-line region [5].
 

Associations of Argk with chemical compounds

  • In conclusion, our results revealed that P. americana arginine kinase is a pan-insect protein and a major CR allergen for CR-allergic Thai patients [6].
  • It is suggested that this difference in evolutionary rate arises because a single gene encodes Drosophila arginine kinase, whereas at least three different genes encode the various forms of vertebrate creatine kinase [7].
  • Adenylate kinase (hereinafter referred to as AK) catalyzes a reversible high-energy phosphoryl transfer reaction between adenine nucleotides [8].
 

Other interactions of Argk

  • We hypothesize that a product of the 2B5 locus and a product of the 75B locus interact to effect this developmental pattern of expression of Drosophila arginine kinase [9].
 

Analytical, diagnostic and therapeutic context of Argk

  • The MAb-bound protein of P. americana was shown to be arginine kinase that reacted to IgE in the sera of all of the CR-allergic Thai patients by immunoblotting, implying its high allergenicity [6].
  • Antiserum to AK was raised in rabbits; its specificity was established by immunodiffusion tests and by immunoreplicas of electropherograms [5].
  • Localization of AK by indirect immunofluorescence on washed myofibrils showed that at least a fraction of the total cellular AK is bound to the contractile apparatus [5].

References

  1. Noninvasive measurement of gene expression in skeletal muscle. Walter, G., Barton, E.R., Sweeney, H.L. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. An A-kinase anchoring protein is required for protein kinase A regulatory subunit localization and morphology of actin structures during oogenesis in Drosophila. Jackson, S.M., Berg, C.A. Development (2002) [Pubmed]
  3. Re-evaluation of the structure and physiological function of guanidino kinases in fruitfly (Drosophila), sea urchin (Psammechinus miliaris) and man. Wyss, M., Maughan, D., Wallimann, T. Biochem. J. (1995) [Pubmed]
  4. Multiple cyclin-dependent kinase complexes and phosphatases control G2/M progression in alfalfa cells. Mészáros, T., Miskolczi, P., Ayaydin, F., Pettkó-Szandtner, A., Peres, A., Magyar, Z., Horváth, G.V., Bakó, L., Fehér, A., Dudits, D. Plant Mol. Biol. (2000) [Pubmed]
  5. Localization of arginine kinase in muscles fibres of Drosophila melanogaster. Lang, A.B., Wyss, C., Eppenberger, H.M. J. Muscle Res. Cell. Motil. (1980) [Pubmed]
  6. Periplaneta americana arginine kinase as a major cockroach allergen among Thai patients with major cockroach allergies. Sookrung, N., Chaicumpa, W., Tungtrongchitr, A., Vichyanond, P., Bunnag, C., Ramasoota, P., Tongtawe, P., Sakolvaree, Y., Tapchaisri, P. Environ. Health Perspect. (2006) [Pubmed]
  7. Evolution of arginine kinase within the genus Drosophila. Collier, G.E. J. Hered. (1990) [Pubmed]
  8. Dynamics of nucleotide metabolism as a supporter of life phenomena. Noma, T. J. Med. Invest. (2005) [Pubmed]
  9. Early gene interaction during prepupal expression of Drosophila arginine kinase. James, J.M., Collier, G.E. Dev. Genet. (1992) [Pubmed]
 
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