High impact information on HELT

• In contrast, only the bHLH domain was required for the heterodimerization with Hey2, whereas only the Orange domain mediated the interaction between Helt and Hes5 [1].
• Thus, Helt has two dimerization domains, and these domains independently select a partner [1].
• Furthermore, Helt repressed transcription from an artificial promoter through binding to the optimal E box elements, as well as transcription from its own promoter [1].
• Helt, a novel basic-helix-loop-helix transcriptional repressor expressed in the developing central nervous system [1].
• Helt was mainly expressed in undifferentiated neural progenitors in some of the developing brain regions, including the mesencephalon and diencephalon, at the neurogenesis stage [1].

Biological context of HELT

• HESL-ACSL1 locus was conserved among human, rat, mouse, and zebrafish genomes [2].
• Here, we identified and characterized human HES-like (HESL), rat Fesl, and rainbow trout fesl genes by using bioinformatics [2].

Anatomical context of HELT

• The latter finding contradicts the generally helt view on the relative resistance of CA1 sector interneurons to the ischemic injury [3].

Associations of HELT with chemical compounds

• Helt encoded a Hey-related bHLH protein containing the bHLH and Orange domains [1].

Other interactions of HELT

• Human HESL gene, located within AC093824.3 genome sequence, was mapped to human chromosome 4q35.1 between ACSL1 and SLC25A4 genes [2].

Analytical, diagnostic and therapeutic context of HELT

• Using in situ hybridization and immunohistochemistry, Helt expression in embryos was investigated [1].

References