Gene Review:
LCK - LCK proto-oncogene, Src family tyrosine...
Homo sapiens
Synonyms:
IMD22, LSK, Leukocyte C-terminal Src kinase, Lymphocyte cell-specific protein-tyrosine kinase, Protein YT16, ...
- Oncogenic activation of the Lck protein accompanies translocation of the LCK gene in the human HSB2 T-cell leukemia. Wright, D.D., Sefton, B.M., Kamps, M.P. Mol. Cell. Biol. (1994)
- The differential expression of LCK and BAFF-receptor and their role in apoptosis in human lymphomas. Paterson, J.C., Tedoldi, S., Craxton, A., Jones, M., Hansmann, M.L., Collins, G., Roberton, H., Natkunam, Y., Pileri, S., Campo, E., Clark, E.A., Mason, D.Y., Marafioti, T. Haematologica (2006)
- Absence of transcription of lck (lymphocyte specific protein tyrosine kinase) message in IL-2-independent, HTLV-I-transformed T cell lines. Koga, Y., Oh-Hori, N., Sato, H., Yamamoto, N., Kimura, G., Nomoto, K. J. Immunol. (1989)
- Chromosomal translocations joining LCK and TCRB loci in human T cell leukemia. Tycko, B., Smith, S.D., Sklar, J. J. Exp. Med. (1991)
- Molecular analysis of the T-cell acute lymphoblastic leukemia-associated t(1;7)(p34;q34) that fuses LCK and TCRB. Burnett, R.C., Thirman, M.J., Rowley, J.D., Diaz, M.O. Blood (1994)
- Association of the tyrosine kinase LCK with phospholipase C-gamma 1 after stimulation of the T cell antigen receptor. Weber, J.R., Bell, G.M., Han, M.Y., Pawson, T., Imboden, J.B. J. Exp. Med. (1992)
- Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus. Jury, E.C., Kabouridis, P.S., Flores-Borja, F., Mageed, R.A., Isenberg, D.A. J. Clin. Invest. (2004)
- Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor. Janes, P.W., Ley, S.C., Magee, A.I. J. Cell Biol. (1999)
- The effect of p56lck, a lymphocyte specific protein tyrosine kinase, on the syncytium formation induced by human immunodeficiency virus envelope glycoprotein. Yoshida, H., Koga, Y., Moroi, Y., Kimura, G., Nomoto, K. Int. Immunol. (1992)
- Neither the LCK nor the FYN kinases are obligatory for IL-2-mediated signal transduction in HTLV-I-infected human T cells. Mills, G.B., Arima, N., May, C., Hill, M., Schmandt, R., Li, J., Miyamoto, N.G., Greene, W.C. Int. Immunol. (1992)
- P56lck A lymphocyte specific protein tyrosine kinase: activation, regulation and signal transduction. Fischer, S., Marie-Cardine, A., Ramos-Morales, F., Bougeret, C., Soula, M., Maridonneau-Parini, I., Benarous, R. Cell. Mol. Biol. (Noisy-le-grand) (1994)
- Interleukin 4 inhibits IL-2-induced proliferation of a human T-leukemia cell line without interfering with p56-LCK kinase activation. Torigoe, T., O'Connor, R., Fagard, R., Fischer, S., Santoli, D., Reed, J.C. Cytokine (1992)
- CD2 signaling in T cells involves tyrosine phosphorylation and activation of the Tec family kinase, EMT/ITK/TSK. King, P.D., Sadra, A., Han, A., Liu, X.R., Sunder-Plassmann, R., Reinherz, E.L., Dupont, B. Int. Immunol. (1996)
- Gene transfer investigations of p56-LCK function in IL-2-dependent T-cell lines: implications for mechanisms of IL-2-signal transduction. Taichman, R.S., Torigoe, T., Tanaka, S., Miyashita, T., Reed, J.C. Cytokine (1992)
- CD8 alpha coreceptor to improve TCR gene transfer to treat melanoma: down-regulation of tumor-specific production of IL-4, IL-5, and IL-10. Willemsen, R.A., Sebestyén, Z., Ronteltap, C., Berrevoets, C., Drexhage, J., Debets, R. J. Immunol. (2006)
- ZAP-70 protein tyrosine kinase is constitutively targeted to the T cell cortex independently of its SH2 domains. Huby, R.D., Iwashima, M., Weiss, A., Ley, S.C. J. Cell Biol. (1997)
- Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner. Seggewiss, R., Loré, K., Greiner, E., Magnusson, M.K., Price, D.A., Douek, D.C., Dunbar, C.E., Wiestner, A. Blood (2005)
- Nocodazole inhibits signal transduction by the T cell antigen receptor. Huby, R.D., Weiss, A., Ley, S.C. J. Biol. Chem. (1998)
- The lymphocyte-specific protein tyrosine kinase p56lck is hyperphosphorylated on serine and tyrosine residues within minutes after activation via T cell receptor or CD2. Danielian, S., Fagard, R., Alcover, A., Acuto, O., Fischer, S. Eur. J. Immunol. (1989)
- Engagement of the CD19 receptor on human B-lineage leukemia cells activates LCK tyrosine kinase and facilitates radiation-induced apoptosis. Waddick, K.G., Chae, H.P., Tuel-Ahlgren, L., Jarvis, L.J., Dibirdik, I., Myers, D.E., Uckun, F.M. Radiat. Res. (1993)
- Lymphocyte-specific protein tyrosine kinase is a novel risk gene for Alzheimer disease. Zhong, W., Yamagata, H.D., Taguchi, K., Akatsu, H., Kamino, K., Yamamoto, T., Kosaka, K., Takeda, M., Kondo, I., Miki, T. J. Neurol. Sci. (2005)
- A lymphocyte-specific protein tyrosine kinase, p56lck, regulates the PMA-induced internalization of CD4. Yoshida, H., Koga, Y., Nakamura, K., Kimura, G., Nomoto, K. Biochim. Biophys. Acta (1992)
- The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. Barber, E.K., Dasgupta, J.D., Schlossman, S.F., Trevillyan, J.M., Rudd, C.E. Proc. Natl. Acad. Sci. U.S.A. (1989)
- Increased ubiquitination and reduced expression of LCK in T lymphocytes from patients with systemic lupus erythematosus. Jury, E.C., Kabouridis, P.S., Abba, A., Mageed, R.A., Isenberg, D.A. Arthritis Rheum. (2003)
- cDNA array analysis identifies thymic LCK as upregulated in moderate murine zinc deficiency before T-lymphocyte population changes. Moore, J.B., Blanchard, R.K., McCormack, W.T., Cousins, R.J. J. Nutr. (2001)
- Localization of Zap70, the gene for a T cell-specific protein tyrosine kinase, to mouse and rat chromosomes by fluorescence in situ hybridization and molecular genetic linkage analyses. Saito, T., Matsuda, Y., Ito, H., Fusaki, N., Hori, T., Yamamoto, T. Mamm. Genome (1997)
- The LCK gene is involved in the t(1;7)(p34;q34) in the T-cell acute lymphoblastic leukemia derived cell line, HSB-2. Burnett, R.C., David, J.C., Harden, A.M., Le Beau, M.M., Rowley, J.D., Diaz, M.O. Genes Chromosomes Cancer (1991)