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SP1  -  Sp1 transcription factor

Gallus gallus

 
 
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Disease relevance of SP1

  • Of the markers tested here, consistent reactivity for tumor tissue was noted only for antibody probes reactive to muscle actin (HHF35, alpha sm-1) or to procollagen type I (SP1. D8); for any given tumor, whether induced by v-src DNA or by Rous sarcoma virus, each of these markers was found only in a subpopulation of tumor cells [1].
  • Decreased Chicken Ovalbumin Upstream Promoter Transcription Factor II Expression in Tamoxifen-Resistant Breast Cancer Cells [2].
 

High impact information on SP1

  • SP3/SP1 transcription activity regulates specific expression of collagen type X in hypertrophic chondrocytes [3].
  • The presumptive promoter and 5'-flanking regions contain an E2 box and consensus binding sites for SP1, for the S8 homeodomain protein, and for two zinc finger clusters within the myeloid progenitor transcription factor, MZF1 [4].
  • Positive regulatory elements active in both cell types included an Ng-CAM proximal promoter with SP1 and cAMP response element motifs extending 447 base pairs upstream of a single RNA start site and a region within the first exon corresponding to 5'-untranslated sequences [5].
  • Potential binding sites for the transcription factors SP1, AP1 and AP2, are present upstream from the transcription start point [6].
  • The sequence of the 5' flanking region contains two SP1-binding sites and a high G+C content suggestive of a housekeeping gene [7].
 

Biological context of SP1

 

Anatomical context of SP1

 

Other interactions of SP1

  • In the present study, we examined the role of SP3/SP1 transcription factors in the regulation of the Col10a1 promoter [3].
 

Analytical, diagnostic and therapeutic context of SP1

  • The SP3/SP1 ratio is higher in hypertrophic versus non-hypertrophic chondrocytes, due to the significant decrease in SP1 in hypertrophic cells detected by real-time PCR and Western blot analyses [3].
  • One dozen eggs were collected and analyzed from each of five different brands from hens fed a diet free of animal fat (SP1), certified organic free-range brown eggs (SP2), uncaged unmedicated brown eggs (SP3), cage-free vegetarian diet brown eggs (SP4), or naturally nested uncaged (SP5) [11].

References

  1. Tumor cells induced by the v-src oncogene are heterogeneous for expression of markers of mesenchyme differentiation. England, J.M., Panella, M.J., Kopen, G.C., Wisner, T.W., Halpern, M.S. Virchows Arch. (1994) [Pubmed]
  2. Decreased Chicken Ovalbumin Upstream Promoter Transcription Factor II Expression in Tamoxifen-Resistant Breast Cancer Cells. Riggs, K.A., Wickramasinghe, N.S., Cochrum, R.K., Watts, M.B., Klinge, C.M. Cancer Res. (2006) [Pubmed]
  3. SP3/SP1 transcription activity regulates specific expression of collagen type X in hypertrophic chondrocytes. Magee, C., Nurminskaya, M., Faverman, L., Galera, P., Linsenmayer, T.F. J. Biol. Chem. (2005) [Pubmed]
  4. Organization of the chick CDC37 gene. Huang, L., Grammatikakis, N., Toole, B.P. J. Biol. Chem. (1998) [Pubmed]
  5. Silencer elements modulate the expression of the gene for the neuron-glia cell adhesion molecule, Ng-CAM. Kallunki, P., Jenkinson, S., Edelman, G.M., Jones, F.S. J. Biol. Chem. (1995) [Pubmed]
  6. Isolation and characterization of the chicken c-sno gene. Givol, I., Boyer, P.L., Hughes, S.H. Gene (1995) [Pubmed]
  7. Isolation and characterization of the chicken cystatin-encoding gene: mapping transcription start point and polyadenylation sites. Colella, R., Bird, J.W. Gene (1993) [Pubmed]
  8. Sequence-specific DNA-binding proteins which interact with (G + C)-rich sequences flanking the chicken c-myc gene. Lobanenkov, V.V., Nicolas, R.H., Plumb, M.A., Wright, C.A., Goodwin, G.H. Eur. J. Biochem. (1986) [Pubmed]
  9. Transcription factor cCP2 controls gene expression in chicken embryonic stem cells. Acloque, H., Mey, A., Birot, A.M., Gruffat, H., Pain, B., Samarut, J. Nucleic Acids Res. (2004) [Pubmed]
  10. Transcription factor Ets-1 regulates fibroblast growth factor-1-mediated angiogenesis in vivo: role of Ets-1 in the regulation of the PI3K/AKT/MMP-1 pathway. Forough, R., Weylie, B., Collins, C., Parker, J.L., Zhu, J., Barhoumi, R., Watson, D.K. J. Vasc. Res. (2006) [Pubmed]
  11. Fatty acid composition and egg components of specialty eggs. Cherian, G., Holsonbake, T.B., Goeger, M.P. Poult. Sci. (2002) [Pubmed]
 
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