Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

INHBB - inhibin, beta B

Gallus gallus

Synonyms: Activin beta-B chain, Inhibin beta B chain

Connolly, D.J. et al., Ziv, T. et al., Mitrani, E. et al., Johnson, P.A. et al.

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High impact information on LOC396126

Using degenerate PCR primers, we have cloned a fragment of the activin beta B chain from chick hypoblast cDNA, and a fragment of the activin beta A chain from chick genomic DNA [1].
We have recently shown that activin can induce the formation of axial structures from chick blastulae and that activin beta-B is transcribed, in the hypoblast of the chick, at the same stage that axial mesoderm is being induced [2].
In addition we also describe the expression pattern of activin beta A and activin beta B, proteins that have previously been shown to be able to interact with follistatin [3].
We were unable to detect the expression of activin beta A during early embryogenesis, whereas activin beta B was first expressed in the extending primitive streak and subsequently in the neural folds [3].
Effect of activin A and inhibin A on expression of the inhibin/activin beta-B-subunit and gonadotropin receptors in granulosa cells of the hen [4].

References

Activin can induce the formation of axial structures and is expressed in the hypoblast of the chick. Mitrani, E., Ziv, T., Thomsen, G., Shimoni, Y., Melton, D.A., Bril, A. Cell (1990) [Pubmed]
Activin can generate ectopic axial structures in chick blastoderm explants. Ziv, T., Shimoni, Y., Mitrani, E. Development (1992) [Pubmed]
Cloning, sequencing, and expressional analysis of the chick homologue of follistatin. Connolly, D.J., Patel, K., Seleiro, E.A., Wilkinson, D.G., Cooke, J. Dev. Genet. (1995) [Pubmed]
Effect of activin A and inhibin A on expression of the inhibin/activin beta-B-subunit and gonadotropin receptors in granulosa cells of the hen. Johnson, P.A., Woodcock, J.R., Kent, T.R. Gen. Comp. Endocrinol. (2006) [Pubmed]

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