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Gene Review

FGF3  -  fibroblast growth factor 3

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High impact information on FGF3

  • Expression of the cysteine-rich fibroblast growth factor (FGF) receptor (CFR) in COS-1 cells strongly inhibits the secretion of co-expressed FGF3 [1].
  • Two members of the fibroblast growth factor family, FGF3 and FGF19, continue to be expressed in this mesodermal population in VAD embryos, and these may be responsible for otic placode induction in the absence of the posterior hindbrain [2].
  • Furthermore, octreotide significantly inhibited chick chorioallantoic membrane neovascularization by the human MCF-10Aint-2 mammary cells secreting the angiogenic protein FGF-3 [3].

Analytical, diagnostic and therapeutic context of FGF3


  1. Cysteine-rich fibroblast growth factor receptor alters secretion and intracellular routing of fibroblast growth factor 3. Köhl, R., Antoine, M., Olwin, B.B., Dickson, C., Kiefer, P. J. Biol. Chem. (2000) [Pubmed]
  2. Distinct roles for hindbrain and paraxial mesoderm in the induction and patterning of the inner ear revealed by a study of vitamin-A-deficient quail. Kil, S.H., Streit, A., Brown, S.T., Agrawal, N., Collazo, A., Zile, M.H., Groves, A.K. Dev. Biol. (2005) [Pubmed]
  3. Inhibition of experimental angiogenesis by the somatostatin analogue octreotide acetate (SMS 201-995). Danesi, R., Agen, C., Benelli, U., Paolo, A.D., Nardini, D., Bocci, G., Basolo, F., Campagni, A., Tacca, M.D. Clin. Cancer Res. (1997) [Pubmed]
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