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Gene Review

GATA6  -  GATA binding protein 6

Gallus gallus

 
 
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High impact information on GATA6

  • The expression of TM, tie-2, GATA-4 and GATA-6 suggests that the isolated embryonic endothelial cell progenitors are derived from the proximal lateral mesoderm where the pre-endocardial tubes form [1].
  • The failure of these GATA-6 control regions to function as enhancers in transfected cardiac myocyte cultures underscores the importance of using transgenic approaches to elucidate transcriptional controls that function in the developing heart [2].
  • Second, the GATA-6 transactivation domain is necessary (and sufficient, when tethered near the ERE) to render this ERU functional [3].
  • Third, ERU enhancer activity is dependent on GATA 6, regardless of whether the resident ERE is imperfect or perfect [3].

References

 
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