The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

LOC396634  -  receptor-type tyrosine-protein phosphatase...

Sus scrofa

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on CD45

 

Biological context of CD45

  • We showed that the CD4+ and CD8+ T-cell populations found in the pig gut are of memory phenotype, defined by CD45 isoform expression, but show few signs of recent activation [5].
 

Anatomical context of CD45

  • In the presence of porcine CD45 mAb human T cell responses were reduced by 30-40% [6].
  • In recipients of vascularized porcine xenografts the usage of anti-pig CD45 mAb could be an approach to block the direct pathway of T cell activation initiated by porcine APC without affecting the endothelium of the graft [6].
  • Results indicate that the percentages of Class I, Class II, CD3, CD8, CD4, CD45, monocyte, gamma-delta T-cell populations, and total number of granulocytes identified using this method were comparable to standard values or to values obtained following separation of white blood cells from red blood cells [7].
  • The specificity of all the mAbs in the CD45R cluster was verified by their ability to immunoprecipitate distinct proteins and to react with CHO cells expressing individual isoforms of CD45 [8].
  • In contrast, the density of expression of the CD45 isoform(s) containing the C exon-generated domain ranged from undetectable to high in CD4+ T cells whereas the amounts were approximately ten-fold lower in B cells [8].
 

Other interactions of CD45

  • Expression of CD18 and CD45 intensively increased from days 1 to 14 with gradual decrease by day 100 [9].
  • Membrane antigens SLA-DR and CD45 were found by day 22, membrane molecules MG-7, 8/1, CD1, CD2 and 74-22 by day 28, Gamma/delta T cells were found initially in extrathymic sites (in the liver) [10].
 

Analytical, diagnostic and therapeutic context of CD45

  • Blood samples were obtained at 7, 14 and 21 days from both normal and clinically affected piglets for routine haematology and for the determination of CD45, CD21, CD4, CD8 and gammadeltaTCR cell markers by flow cytometry [11].
  • Evolving changes in expression of CD45, CD45R, CD44, CD18 and very late antigen type-4 (VLA-4) also occurred following thymectomy [12].

References

  1. T-cell-specific immunosuppression results in more than 53 days survival of porcine islets of langerhans in the monkey. Rijkelijkhuizen, J.K., Haanstra, K.G., Wubben, J., Töns, A., Roos, A., van Gijlswijk-Janssen, D.J., Ringers, J., Bouwman, E., Jonker, M. Transplantation (2003) [Pubmed]
  2. A preclinical model for laryngeal transplantation: anatomy and mucosal immunology of the porcine larynx. Gorti, G.K., Birchall, M.A., Haverson, K., Macchiarini, P., Bailey, M. Transplantation (1999) [Pubmed]
  3. Isolation and purification of lymphocyte subsets from gut-associated lymphoid tissue in neonatal swine. Solano-Aguilar, G.I., Vengroski, K.G., Beshah, E., Lunney, J.K. J. Immunol. Methods (2000) [Pubmed]
  4. Professional and non-professional antigen-presenting cells in the porcine small intestine. Haverson, K., Singha, S., Stokes, C.R., Bailey, M. Immunology (2000) [Pubmed]
  5. T-cell populations in the pig intestinal lamina propria: memory cells with unusual phenotypic characteristics. Haverson, K., Bailey, M., Stokes, C.R. Immunology (1999) [Pubmed]
  6. Modulation of human anti-pig T cell responses by monoclonal antibodies directed to porcine CD45 molecules. Bedke, T., Baars, W., Schwinzer, R. Ann. Transplant. (2003) [Pubmed]
  7. A simple and rapid flow cytometric method for detection of porcine cell surface markers. Stabel, T.J., Bolin, S.R., Pesch, B.A., Rahner, T.E. J. Immunol. Methods (2000) [Pubmed]
  8. Definition of the specificity of monoclonal antibodies against porcine CD45 and CD45R: report from the CD45/CD45R and CD44 subgroup of the Second International Swine CD Workshop. Zuckermann, F.A., Peavey, C., Schnitzlein, W.M., Schabacker, D., Husmann, R.J., Yang, H., Saalmüller, A., Lunney, J.K. Vet. Immunol. Immunopathol. (1998) [Pubmed]
  9. Postnatal functional maturation of blood phagocytes in pig. Zelnickova, P., Kovaru, H., Pesak, S., Lojek, A., Matalova, E., Ondracek, J., Kovaru, F. Vet. Immunol. Immunopathol. (2006) [Pubmed]
  10. Early ontogeny of immune cells and their functions in the fetal pig. Trebichavský, I., Tlaskalová, H., Cukrowska, B., Splíchal, I., Sinkora, J., Oeháková, Z., Sinkora, M., Pospísil, R., Kováøù, F., Charley, B., Binns, R., White, A. Vet. Immunol. Immunopathol. (1996) [Pubmed]
  11. Changes in peripheral blood leukocyte populations in pigs with naturally occurring exudative epidermitis. Nofrarías, M., Pujols, J., Segalés, J., Gibert, X., Majó, N. Res. Vet. Sci. (2006) [Pubmed]
  12. Major long-term changes in gamma delta T-cell receptor-positive and CD2+ T-cell subsets after neonatal thymectomy in the pig: a longitudinal study lasting nearly 2 years. Licence, S.T., Binns, R.M. Immunology (1995) [Pubmed]
 
WikiGenes - Universities