Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

GHRHR - growth hormone releasing hormone receptor

Sus scrofa

Luque, R.M. et al., Sun, H.S. et al., Matteri, R.L. et al., Hsiung, H.M. et al.

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High impact information on GHRHR

Interestingly, administration of the activator of adenylate cyclase, forskolin, decreased GHRH-R mRNA levels but had no effect on GHS-R, thus suggesting a distinct contribution of the various intracellular signals operating in somatotropes to the regulation of the expression of these receptors [1].
Accordingly, an atypical activator of adenylate cyclase in the pig somatotrope is low-dose (10(-13) m) somatostatin, which also suppressed GHRH-R mRNA levels without altering GHS-R expression [1].
Secretion of GH by pituitary somatotropes is primarily stimulated by the hypothalamic GHRH through the activation of a specific G protein-coupled receptor, GHRH receptor (GHRH-R) [1].
By using a pig-rodent somatic cell hybrid panel, GHRHR was mapped to pig chromosome 18 (SSC18) with 100% concordance, and the regional assignment was SSC18q24 with 89% concordance [2].
Primers were designed from the pig GHRHR sequence to amplify a 1.65-kb intronic fragment between exons 6 and 7 [2].

Biological context of GHRHR

One novel receptor cDNA fragment was used to screen a porcine pituitary cDNA library and a full-length cDNA encoding a putative porcine GHRH receptor of 451 amino acids was isolated [3].
Our mapping of pig GHRHR increases the comparative information available on the SSC18 maps and further confirms the synteny conservation between HSA7 and SSC18 [2].
The GHRHR and IGFBP3 were found to map near to each other on human chromosome 7 (HSA7), and the pig IGFBP3 gene has been mapped to SSC18 by others [2].

Associations of GHRHR with chemical compounds

Finally, dexamethasone did not modify GHRH-R or GHS-R expression [1].

Regulatory relationships of GHRHR

Age-related declines in in vitro GH secretion were observed regardless of if the cells were stimulated by GHRH or by secretagogues that bypass the GHRH receptor (P < 0.001) [4].

Other interactions of GHRHR

Age-related decreases in secretory function may be mediated by concurrent mechanisms relating to the expression of the GHRH receptor and of GH [4].

References

Homologous and heterologous regulation of pituitary receptors for ghrelin and growth hormone-releasing hormone. Luque, R.M., Kineman, R.D., Park, S., Peng, X.D., Gracia-Navarro, F., Castaño, J.P., Malagon, M.M. Endocrinology (2004) [Pubmed]
Mapping of growth hormone releasing hormone receptor to swine chromosome 18. Sun, H.S., Taylor, C., Robic, A., Wang, L., Rothschild, M.F., Tuggle, C.K. Anim. Genet. (1997) [Pubmed]
Structure and functional expression of a complementary DNA for porcine growth hormone-releasing hormone receptor. Hsiung, H.M., Smith, D.P., Zhang, X.Y., Bennett, T., Rosteck, P.R., Lai, M.H. Neuropeptides (1993) [Pubmed]
Somatotroph function in the neonatal pig. Matteri, R.L., Carroll, J.A. Domest. Anim. Endocrinol. (1997) [Pubmed]

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