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Gene Review:
GHSR - growth hormone secretagogue receptor
Sus scrofa
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High impact information on GHSR
- Interestingly, administration of the activator of adenylate cyclase, forskolin, decreased GHRH-R mRNA levels but had no effect on GHS-R, thus suggesting a distinct contribution of the various intracellular signals operating in somatotropes to the regulation of the expression of these receptors [1].
- Accordingly, an atypical activator of adenylate cyclase in the pig somatotrope is low-dose (10(-13) m) somatostatin, which also suppressed GHRH-R mRNA levels without altering GHS-R expression [1].
- GH is also released in response to ghrelin, a peptide produced in the stomach, hypothalamus, and pituitary that activates somatotropes via a distinct G protein-coupled receptor, referred to as the GH secretagogue receptor (GHS-R) [1].
Associations of GHSR with chemical compounds
- Finally, dexamethasone did not modify GHRH-R or GHS-R expression [1].
Other interactions of GHSR
- Here, we have analyzed the expression of both GHRH-R and GHS-R (by multiplex RT-PCR) in porcine pituitary cell cultures, after acute (4 h) treatment with GHRH or ghrelin as well as with other regulators of somatotropes (somatostatin, dexamethasone) [1].
References
- Homologous and heterologous regulation of pituitary receptors for ghrelin and growth hormone-releasing hormone. Luque, R.M., Kineman, R.D., Park, S., Peng, X.D., Gracia-Navarro, F., Castaño, J.P., Malagon, M.M. Endocrinology (2004) [Pubmed]
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