Gene Review:
LIF - leukemia inhibitory factor
Homo sapiens
Synonyms:
CDF, D factor, DIA, Differentiation-stimulating factor, HILDA, ...
- The human hepatocyte growth factor (HGF) gene is transcriptionally activated by leukemia inhibitory factor through the Stat binding element. Tomida, M., Saito, T. Oncogene (2004)
- Differential effects of oncostatin M and leukaemia inhibitory factor expression in astrocytoma cells. Kasza, A., Rogowski, K., Kilarski, W., Sobota, R., Bernas, T., Dobrucki, J., Travis, J., Koj, A., Bugno, M., Kordula, T. Biochem. J. (2001)
- Oncostatin M-specific receptor mediates inhibition of breast cancer cell growth and down-regulation of the c-myc proto-oncogene. Liu, J., Spence, M.J., Wallace, P.M., Forcier, K., Hellström, I., Vestal, R.E. Cell Growth Differ. (1997)
- Crystallization and preliminary X-ray analysis of leukemia inhibitory factor. Betzel, C., Visanji, M., Dauter, Z., Fourme, R., Weber, W., Marnitz, U., Boone, T., Pope, J., Miller, J., Hawkins, N. FEBS Lett. (1993)
- Modulation of LIF expression in human melanoma cells by oncostatin M. Heymann, D., Blanchard, F., Raher, S., De Groote, D., Godard, A. Immunol. Lett. (1995)
- Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells. Duluc, D., Delneste, Y., Tan, F., Moles, M.P., Grimaud, L., Lenoir, J., Preisser, L., Anegon, I., Catala, L., Ifrah, N., Descamps, P., Gamelin, E., Gascan, H., Hebbar, M., Jeannin, P. Blood (2007)
- Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions. Piccinni, M.P., Beloni, L., Livi, C., Maggi, E., Scarselli, G., Romagnani, S. Nat. Med. (1998)
- Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Williams, R.L., Hilton, D.J., Pease, S., Willson, T.A., Stewart, C.L., Gearing, D.P., Wagner, E.F., Metcalf, D., Nicola, N.A., Gough, N.M. Nature (1988)
- Leukemia-inhibitory factor-neuroimmune modulator of endocrine function. Auernhammer, C.J., Melmed, S. Endocr. Rev. (2000)
- Leukemia inhibitory factor: a novel bone-active cytokine. Reid, L.R., Lowe, C., Cornish, J., Skinner, S.J., Hilton, D.J., Willson, T.A., Gearing, D.P., Martin, T.J. Endocrinology (1990)
- Leukemia inhibitory factor binds to human breast cancer cells and stimulates their proliferation. Estrov, Z., Samal, B., Lapushin, R., Kellokumpu-Lehtinen, P., Sahin, A.A., Kurzrock, R., Talpaz, M., Aggarwal, B.B. J. Interferon Cytokine Res. (1995)
- Stimulation of HIV replication in mononuclear phagocytes by leukemia inhibitory factor. Broor, S., Kusari, A.B., Zhang, B., Seth, P., Richman, D.D., Carson, D.A., Wachsman, W., Lotz, M. J. Acquir. Immune Defic. Syndr. (1994)
- Differentiation factor/leukemia inhibitory factor protection against lethal endotoxemia in mice: synergistic effect with interleukin 1 and tumor necrosis factor. Alexander, H.R., Wong, G.G., Doherty, G.M., Venzon, D.J., Fraker, D.L., Norton, J.A. J. Exp. Med. (1992)
- AIDS-associated Kaposi's sarcoma (KS) cells express oncostatin M (OM)-specific receptor but not leukemia inhibitory factor/OM receptor or interleukin-6 receptor. Complete block of OM-induced KS cell growth and OM binding by anti-gp130 antibodies. Murakami-Mori, K., Taga, T., Kishimoto, T., Nakamura, S. J. Clin. Invest. (1995)
- The box-1 region of the leukemia inhibitory factor receptor alpha-chain cytoplasmic domain is sufficient for hemopoietic cell proliferation and differentiation. Zhang, Y., Willson, T., Metcalf, D., Cary, D., Hilton, D.J., Clark, R., Nicola, N.A. J. Biol. Chem. (1998)
- Characterization of the receptor binding sites of human leukemia inhibitory factor and creation of antagonists. Hudson, K.R., Vernallis, A.B., Heath, J.K. J. Biol. Chem. (1996)
- Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. Mosley, B., De Imus, C., Friend, D., Boiani, N., Thoma, B., Park, L.S., Cosman, D. J. Biol. Chem. (1996)
- Cytokines which signal through the LIF receptor and their actions in the nervous system. Murphy, M., Dutton, R., Koblar, S., Cheema, S., Bartlett, P. Prog. Neurobiol. (1997)
- FR901228, an inhibitor of histone deacetylases, increases the cellular responsiveness to IL-6 type cytokines by enhancing the expression of receptor proteins. Blanchard, F., Kinzie, E., Wang, Y., Duplomb, L., Godard, A., Held, W.A., Asch, B.B., Baumann, H. Oncogene (2002)
- Immunohistochemical analysis of the IL-6 family of cytokines and their receptors in benign, hyperplasic, and malignant human prostate. Royuela, M., Ricote, M., Parsons, M.S., García-Tuñón, I., Paniagua, R., de Miguel, M.P. J. Pathol. (2004)
- Distinct effects of Broncho-Vaxom (OM-85 BV) on gp130 binding cytokines. Roth, M., Block, L.H. Thorax (2000)
- Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. Paling, N.R., Wheadon, H., Bone, H.K., Welham, M.J. J. Biol. Chem. (2004)
- Leukemia inhibitory factor (LIF) and oncastsin M (OSM) high affinity binding require additional receptor subunits besides GP130 and GP190. Heymann, D., Godard, A., Raher, S., Bentouimou, N., Blanchard, F., Cherel, M., Hallet, M.M., Jacques, Y. Cytokine (1996)
- Mutations in the immunoglobulin-like domain of gp190, the leukemia inhibitory factor (LIF) receptor, increase or decrease its affinity for LIF. Bitard, J., Daburon, S., Duplomb, L., Blanchard, F., Vuisio, P., Jacques, Y., Godard, A., Heath, J.K., Moreau, J.F., Taupin, J.L. J. Biol. Chem. (2003)
- 15-Deoxy-delta12,14-prostaglandin J2 regulates leukemia inhibitory factor signaling through JAK-STAT pathway in mouse embryonic stem cells. Rajasingh, J., Bright, J.J. Exp. Cell Res. (2006)
- Leukemia inhibitory factor triggers activation of signal transducer and activator of transcription 3, proliferation, invasiveness, and altered protease expression in choriocarcinoma cells. Fitzgerald, J.S., Tsareva, S.A., Poehlmann, T.G., Berod, L., Meissner, A., Corvinus, F.M., Wiederanders, B., Pfitzner, E., Markert, U.R., Friedrich, K. Int. J. Biochem. Cell Biol. (2005)
- Cytokine-cytokine synergy and protein kinase C in the regulation of lung fibroblast leukemia inhibitory factor. Elias, J.A., Zheng, T., Whiting, N.L., Marcovici, A., Trow, T.K. Am. J. Physiol. (1994)
- The mannose 6-phosphate/insulin-like growth factor II receptor is a nanomolar affinity receptor for glycosylated human leukemia inhibitory factor. Blanchard, F., Raher, S., Duplomb, L., Vusio, P., Pitard, V., Taupin, J.L., Moreau, J.F., Hoflack, B., Minvielle, S., Jacques, Y., Godard, A. J. Biol. Chem. (1998)
- Phosphorylation of human gp130 at Ser-782 adjacent to the Di-leucine internalization motif. Effects on expression and signaling. Gibson, R.M., Schiemann, W.P., Prichard, L.B., Reno, J.M., Ericsson, L.H., Nathanson, N.M. J. Biol. Chem. (2000)
- Leukemia inhibitory factor-induced phosphorylation of STAP-2 on tyrosine-250 is involved in its STAT3-enhancing activity. Sekine, Y., Tsuji, S., Ikeda, O., Kakisaka, M., Sugiyama, K., Yoshimura, A., Matsuda, T. Biochem. Biophys. Res. Commun. (2007)
- Independent roles of SOCS-3 and SHP-2 in the regulation of neuronal gene expression by leukemia inhibitory factor. Bartoe, J.L., Nathanson, N.M. Brain Res. Mol. Brain Res. (2002)
- Leukaemia inhibitory factor enhances tissue factor expression in human monocyte-derived macrophages: a gp130-mediated mechanism. Meisel, S.R., Shimon, I., Edgington, T.S., Melmed, S., Cercek, B., Shah, P.K. Br. J. Haematol. (1999)
- Oncostatin M, leukemia inhibitory factor, and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer, gp130. Nishimoto, N., Ogata, A., Shima, Y., Tani, Y., Ogawa, H., Nakagawa, M., Sugiyama, H., Yoshizaki, K., Kishimoto, T. J. Exp. Med. (1994)
- Leukemia inhibitory factor (LIF), cardiotrophin-1, and oncostatin M share structural binding determinants in the immunoglobulin-like domain of LIF receptor. Plun-Favreau, H., Perret, D., Diveu, C., Froger, J., Chevalier, S., Lelièvre, E., Gascan, H., Chabbert, M. J. Biol. Chem. (2003)
- Identification of a gp130 cytokine receptor critical site involved in oncostatin M response. Olivier, C., Auguste, P., Chabbert, M., Lelièvre, E., Chevalier, S., Gascan, H. J. Biol. Chem. (2000)
- Circulating IL-6-type cytokines and sIL-6R in patients with multiple myeloma. Wierzbowska, A., Urbańska-Ryś, H., Robak, T. Br. J. Haematol. (1999)
- Coexpression of oncostatin M and its receptors and evidence for STAT3 activation in human ovarian carcinomas. Savarese, T.M., Campbell, C.L., McQuain, C., Mitchell, K., Guardiani, R., Quesenberry, P.J., Nelson, B.E. Cytokine (2002)