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Gene Review

blaZ  -  beta-lactamase

Staphylococcus aureus

 
 
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Disease relevance of blaZ

 

High impact information on blaZ

 

Chemical compound and disease context of blaZ

 

Biological context of blaZ

 

Anatomical context of blaZ

 

Associations of blaZ with chemical compounds

  • Using this method, 40% of the isolates possessing the blaZ gene were classified as susceptible; however, majority of these isolates produced beta-lactamase when tested with nitrocefin [18].
  • In some institutions methicillin-resistance among coagulase-negative staphylococci has reached 75%, and in others the incidence of extended-spectrum beta-lactamase producing Gram-negative bacilli has risen markedly [19].
 

Other interactions of blaZ

  • Complete pbp2 sequences were determined for three BORSA, corresponding to ST25, ST1 and ST47, which were selected on the basis of lacking blaZ-encoded beta-lactamase [20].

References

  1. Organization of the antiseptic resistance gene qacA and Tn552-related beta-lactamase genes in multidrug- resistant Staphylococcus haemolyticus strains of animal and human origins. Anthonisen, I.L., Sunde, M., Steinum, T.M., Sidhu, M.S., Sørum, H. Antimicrob. Agents Chemother. (2002) [Pubmed]
  2. Genes involved in the regulation of beta-lactamase production in enterococci and staphylococci. Zscheck, K.K., Murray, B.E. Antimicrob. Agents Chemother. (1993) [Pubmed]
  3. Multiple-drug-resistant bacteria in patients with severe acute exacerbation of chronic obstructive pulmonary disease: Prevalence, risk factors, and outcome. Nseir, S., Di Pompeo, C., Cavestri, B., Jozefowicz, E., Nyunga, M., Soubrier, S., Roussel-Delvallez, M., Saulnier, F., Mathieu, D., Durocher, A. Crit. Care Med. (2006) [Pubmed]
  4. The Meropenem Yearly Susceptibility Test Information Collection antimicrobial susceptibility program in Spain: a 5-year analysis. Pascual, A., Perea, E., Alvarez, M., Casal, M., Garcia de Lomas, J., Garcia Rodríguez, J.A., Martin, R., Soria, G., Zapardiel, J. Diagn. Microbiol. Infect. Dis. (2007) [Pubmed]
  5. In vitro activities of ertapenem against drug-resistant Streptococcus pneumoniae and other respiratory pathogens from 12 Asian countries. Song, J.H., Ko, K.S., Lee, M.Y., Park, S., Baek, J.Y., Lee, J.Y., Heo, S.T., Kwon, K.T., Ryu, S.Y., Oh, W.S., Peck, K.R., Lee, N.Y. Diagn. Microbiol. Infect. Dis. (2006) [Pubmed]
  6. Lysine N(zeta)-Decarboxylation in the BlaR1 Protein from Staphylococcus aureus at the Root of Its Function As an Antibiotic Sensor. Cha, J., Mobashery, S. J. Am. Chem. Soc. (2007) [Pubmed]
  7. Correlation between the resistance genotype determined by multiplex PCR assays and the antibiotic susceptibility patterns of Staphylococcus aureus and Staphylococcus epidermidis. Martineau, F., Picard, F.J., Lansac, N., M¿enard, C., Roy, P.H., Ouellette, M., Bergeron, M.G. Antimicrob. Agents Chemother. (2000) [Pubmed]
  8. Comparison of enterococcal and staphylococcal beta-lactamase-encoding fragments. Smith, M.C., Murray, B.E. Antimicrob. Agents Chemother. (1992) [Pubmed]
  9. Pasteurization is effective against multidrug-resistant bacteria. Wang, C.Y., Wu, H.D., Lee, L.N., Chang, H.T., Hsu, Y.L., Yu, C.J., Yang, P.C., Hsueh, P.R. American journal of infection control. (2006) [Pubmed]
  10. Tigecycline: A glycylcycline antimicrobial agent. Doan, T.L., Fung, H.B., Mehta, D., Riska, P.F. Clinical therapeutics. (2006) [Pubmed]
  11. Synthesis and SAR study of novel 7-(pyridinium-3-yl)-carbonyl imidazo[5,1-b]thiazol-2-yl carbapenems. Maruyama, T., Kano, Y., Yamamoto, Y., Kurazono, M., Iwamatsu, K., Atsumi, K., Shitara, E. Bioorg. Med. Chem. (2007) [Pubmed]
  12. Clinical characteristics and persistence of bovine mastitis caused by different species of coagulase-negative staphylococci identified with API or AFLP. Taponen, S., Simojoki, H., Haveri, M., Larsen, H.D., Pyörälä, S. Vet. Microbiol. (2006) [Pubmed]
  13. Microarray-based characterisation of a Panton-Valentine leukocidin-positive community-acquired strain of methicillin-resistant Staphylococcus aureus. Monecke, S., Slickers, P., Hotzel, H., Richter-Huhn, G., Pohle, M., Weber, S., Witte, W., Ehricht, R. Clin. Microbiol. Infect. (2006) [Pubmed]
  14. Community-acquired methicillin resistant Staphylococcus aureus skin infection. Halem, M., Trent, J., Green, J., Kerdel, F. Seminars in cutaneous medicine and surgery. (2006) [Pubmed]
  15. Mechanisms of resistance of bacteria causing ventilator-associated pneumonia. Szabo, D., Silveira, F., Fujitani, S., Paterson, D.L. Clin. Chest Med. (2005) [Pubmed]
  16. Erythromycin for prokinesis: imprudent prescribing? Dall'antonia, M., Wilks, M., Coen, P.G., Bragman, S., Millar, M.R. Critical care (London, England) (2006) [Pubmed]
  17. Polyphenolic constituent structures of Zanthoxylum piperitum fruit and the antibacterial effects of its polymeric procyanidin on methicillin-resistant Staphylococcus aureus. Kusuda, M., Inada, K., Ogawa, T.O., Yoshida, T., Shiota, S., Tsuchiya, T., Hatano, T. Biosci. Biotechnol. Biochem. (2006) [Pubmed]
  18. Comparison of phenotypic and genotypic detection of penicillin G resistance of Staphylococcus aureus isolated from bovine intramammary infection. Haveri, M., Suominen, S., Rantala, L., Honkanen-Buzalski, T., Pyörälä, S. Vet. Microbiol. (2005) [Pubmed]
  19. Emerging problem pathogens: A review of resistance patterns over time. Akova, M. Int. J. Infect. Dis. (2006) [Pubmed]
  20. Identification of different clonal complexes and diverse amino acid substitutions in penicillin-binding protein 2 (PBP2) associated with borderline oxacillin resistance in Canadian Staphylococcus aureus isolates. Nadarajah, J., Lee, M.J., Louie, L., Jacob, L., Simor, A.E., Louie, M., McGavin, M.J. J. Med. Microbiol. (2006) [Pubmed]
 
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