The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

frzb-1  -  Frzb-1 protein

Xenopus laevis

Synonyms: Sfrp3, frezzled, frzb
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Frzb-1

  • These observations implicate Frzb in axial patterning and support the concept that Frzb binds and inactivates Xwnt-8 during gastrulation, preventing inappropriate ventral signaling in developing dorsal tissues [1].
  • Unlike Frizzled proteins, endogenous Frzb was soluble [1].
  • Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8 [1].
  • Gsc acts in deeper vegetal cells, where it regulates Frzb expression to maintain Xnot expression in the neighbouring notochord territory [2].
  • Reciprocally, Xnr2 induced dorsoanterior endodermal markers, such as cerberus, Xhex-1 and Frzb, in animal cap ectoderm [3].
 

Anatomical context of Frzb-1

  • Siamois induces Cerberus, Frzb1 and Xlim1 in vegetal blastomeres and vegetal induction by Siamois is dependent on endogenous TGFbeta signals [4].
 

Other interactions of Frzb-1

  • Furthermore, Frzb blocked induction of MyoD, an action reported recently for a dominant-negative Xwnt-8 [1].
  • A direct screen for secreted proteins in Xenopus embryos identifies distinct activities for the Wnt antagonists Crescent and Frzb-1 [5].
  • Consistent with the absence of head organizer activity in Siamois-expressing animal pole tissue, Siamois did not induce animal expression of Cerberus, Frzb1 and Xlim1, genes implicated in anterior development [4].

References

 
WikiGenes - Universities