Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

gsk3b - glycogen synthase kinase 3 beta

Xenopus laevis

Synonyms: gsk-3, gsk3, gsk3-beta, gsk3beta, xgsk-3

Yost, C. et al., Pierce, S.B. et al., Yost, C. et al., Pierce, S.B. et al.

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High impact information on Xgsk-3

Using a two-hybrid screen, we identified GBP, a maternal Xgsk-3-binding protein that is homologous to a T cell protooncogene in three well-conserved domains [1].
Recent evidence indicates that beta-catenin is dorsally stabilized by the localized inhibition of the kinase Xgsk-3, utilizing a novel Wnt ligand-independent mechanism [1].
The serine/threonine kinase Xgsk-3 and the intracellular protein beta-catenin are necessary for the establishment of the dorsal-ventral axis in Xenopus [2].
Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3 [3].
To determine whether Xgsk-3 is involved in ectodermal patterning, Xgsk-3 was ectopically overexpressed in the presumptive ectoderm [4].

Anatomical context of Xgsk-3

The Xenopus homolog of glycogen synthase kinase-3, Xgsk-3, plays a major role in regulating the formation of the dorsal-ventral axis, most likely through effects on the mesoderm [4].

References

GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis. Yost, C., Farr, G.H., Pierce, S.B., Ferkey, D.M., Chen, M.M., Kimelman, D. Cell (1998) [Pubmed]
The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Yost, C., Torres, M., Miller, J.R., Huang, E., Kimelman, D., Moon, R.T. Genes Dev. (1996) [Pubmed]
Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3. Pierce, S.B., Kimelman, D. Development (1995) [Pubmed]
Overexpression of Xgsk-3 disrupts anterior ectodermal patterning in Xenopus. Pierce, S.B., Kimelman, D. Dev. Biol. (1996) [Pubmed]

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