Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

malE - maltose ABC transporter substrate-binding...

Escherichia coli UTI89

Tokunaga, M. et al., Jin, S. et al., Han, D.C. et al., Yamada, M. et al., Hülsmann, A. et al.

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Disease relevance of malE

We fused the wild-type Agrobacterium tumefaciens virG gene and the constitutive virGN54D allele to the malE gene of Escherichia coli, and studied the binding of MBP-VirG fusions to the autoregulated virG promoter [1].
The malE gene lacking the DNA sequence that encodes the signal sequence was expressed in Escherichia coli [2].

High impact information on malE

Escherichia coli strain MM18 cells containing malE-lacZ hybrid protein was reported to accumulate prolipoprotein when they were induced with maltose [Ito, K., Bassford, P. J. & Beckwith, J. (1981) Cell 24, 707-717] [3].
The plasmid with the malE-pilR fusion, when introduced into a non-piliated pilR mutant strain of P. aeruginosa, restored piliation, indicating that the hybrid protein retains PilR function in vivo [4].
The product of the malE-lacZ gene fusion was reported to compete with some proteins including outer membrane lipoprotein in the protein translocation across the Escherichia coli membrane [5].

Associations of malE with chemical compounds

PilR was overproduced by fusing pilR to the gene for the maltose-binding protein (malE), yielding a MalE-PilR hybrid protein [4].

References

A mutation in the receiver domain of the Agrobacterium tumefaciens transcriptional regulator VirG increases its affinity for operator DNA. Han, D.C., Winans, S.C. Mol. Microbiol. (1994) [Pubmed]
Maltose and maltodextrin transport in the thermoacidophilic gram-positive bacterium Alicyclobacillus acidocaldarius is mediated by a high-affinity transport system that includes a maltose binding protein tolerant to low pH. Hülsmann, A., Lurz, R., Scheffel, F., Schneider, E. J. Bacteriol. (2000) [Pubmed]
Post-translational modification and processing of Escherichia coli prolipoprotein in vitro. Tokunaga, M., Tokunaga, H., Wu, H.C. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
PilR, a transcriptional regulator of piliation in Pseudomonas aeruginosa, binds to a cis-acting sequence upstream of the pilin gene promoter. Jin, S., Ishimoto, K.S., Lory, S. Mol. Microbiol. (1994) [Pubmed]
Translocation of colicin E1 through cytoplasmic membrane of Escherichia coli. Yamada, M., Miki, T., Nakazawa, A. FEBS Lett. (1982) [Pubmed]

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