The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Cat  -  Catalase

Drosophila melanogaster

Synonyms: CAT, CATA, CG6871, CT21282, CatA, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Psychiatry related information on Cat

 

High impact information on Cat

 

Biological context of Cat

 

Anatomical context of Cat

  • Ectopic expression of catalase in Drosophila mitochondria increases stress resistance but not longevity [10].
  • Catalase, an antioxidative enzyme expressed in the cytosol and peroxisomes of Drosophila, was targetted ectopically to the mitochondrial matrix by fusion of a leader peptide derived from ornithine aminotransferase with its N-terminus [10].
  • Because of the presence of catalase as well as by their structural appearance, these organelles are to be identified as microperoxisomes [11].
  • Catalase activity is restricted to the very last stages of oogenesis (stage 13-14) and appears to be located in membrane-bound organelles of the ooplasm which are continuous with the endoplasmic reticulum [11].
 

Associations of Cat with chemical compounds

 

Physical interactions of Cat

 

Regulatory relationships of Cat

 

Other interactions of Cat

  • Significant increases in the activities of both CuZn-SOD and catalase had no beneficial effect on survivorship in relatively long-lived y w mutant flies and were associated with slightly decreased life spans in wild type flies of the Oregon-R strain [3].
  • Our data show that the expression of the genes encoding known ROS scavengers [superoxide dismutase (SOD) and catalase] is not regulated by dADAR [18].
  • Transcriptional regulation of the Drosophila catalase gene by the DRE/DREF system [17].
  • Spatially, it was ascertained that catalase expression is mostly confined to tissues related to intermediary metabolism, digestive and adipose systems as well as oenocytes [12].
  • 3AT inhibited up to 80% of the catalase activity with concordant small increases in the in vitro activities of sn-glycerol-3-phosphate dehydrogenase, fumarase, and malic enzyme, but with a 16% reduction in the in vivo incorporation of label from [14C]glucose into lipid [19].
 

Analytical, diagnostic and therapeutic context of Cat

References

  1. Overexpression of Mn-containing superoxide dismutase in transgenic Drosophila melanogaster. Mockett, R.J., Orr, W.C., Rahmandar, J.J., Benes, J.J., Radyuk, S.N., Klichko, V.I., Sohal, R.S. Arch. Biochem. Biophys. (1999) [Pubmed]
  2. FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Sun, J., Tower, J. Mol. Cell. Biol. (1999) [Pubmed]
  3. Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity in Drosophila melanogaster. Orr, W.C., Mockett, R.J., Benes, J.J., Sohal, R.S. J. Biol. Chem. (2003) [Pubmed]
  4. Simultaneous overexpression of copper- and zinc-containing superoxide dismutase and catalase retards age-related oxidative damage and increases metabolic potential in Drosophila melanogaster. Sohal, R.S., Agarwal, A., Agarwal, S., Orr, W.C. J. Biol. Chem. (1995) [Pubmed]
  5. cDNA and deduced amino acid sequence of Drosophila catalase. Orr, E.C., Bewley, G.C., Orr, W.C. Nucleic Acids Res. (1990) [Pubmed]
  6. Longevity determination genes in Drosophila melanogaster. Aigaki, T., Seong, K.H., Matsuo, T. Mech. Ageing Dev. (2002) [Pubmed]
  7. A putative glutathione peroxidase of Drosophila encodes a thioredoxin peroxidase that provides resistance against oxidative stress but fails to complement a lack of catalase activity. Missirlis, F., Rahlfs, S., Dimopoulos, N., Bauer, H., Becker, K., Hilliker, A., Phillips, J.P., Jäckle, H. Biol. Chem. (2003) [Pubmed]
  8. The genetics of catalase in Drosophila melanogaster: isolation and characterization of acatalasemic mutants. Mackay, W.J., Bewley, G.C. Genetics (1989) [Pubmed]
  9. Molecular analysis of the Drosophila catalase gene. Orr, W.C., Orr, E.C., Legan, S.K., Sohal, R.S. Arch. Biochem. Biophys. (1996) [Pubmed]
  10. Ectopic expression of catalase in Drosophila mitochondria increases stress resistance but not longevity. Mockett, R.J., Bayne, A.C., Kwong, L.K., Orr, W.C., Sohal, R.S. Free Radic. Biol. Med. (2003) [Pubmed]
  11. Cytochemistry of late ovarian chambers of Drosophila melanogaster. Giorgi, F., Deri, P. Histochemistry (1976) [Pubmed]
  12. Profiling catalase gene expression in Drosophila melanogaster during development and aging. Klichko, V.I., Radyuk, S.N., Orr, W.C. Arch. Insect Biochem. Physiol. (2004) [Pubmed]
  13. Effect of age on superoxide dismutase, catalase, glutathione reductase, inorganic peroxides, TBA-reactive material, GSH/GSSG, NADPH/NADP+ and NADH/NAD+ in Drosophila melanogaster. Sohal, R.S., Arnold, L., Orr, W.C. Mech. Ageing Dev. (1990) [Pubmed]
  14. Genetic variation affecting the expression of catalase in Drosophila melanogaster: correlations with rates of enzyme synthesis and degradation. Bewley, G.C., Laurie-Ahlberg, C.C. Genetics (1984) [Pubmed]
  15. Antioxidative effects of melatonin in Drosophila melanogaster: antagonization of damage induced by the inhibition of catalase. Coto-Montes, A., Hardeland, R. J. Pineal Res. (1999) [Pubmed]
  16. Molecular characterization and rescue of acatalasemic mutants of Drosophila melanogaster. Griswold, C.M., Matthews, A.L., Bewley, K.E., Mahaffey, J.W. Genetics (1993) [Pubmed]
  17. Transcriptional regulation of the Drosophila catalase gene by the DRE/DREF system. Park, S.Y., Kim, Y.S., Yang, D.J., Yoo, M.A. Nucleic Acids Res. (2004) [Pubmed]
  18. Regulatory role of dADAR in ROS metabolism in Drosophila CNS. Chen, L., Rio, D.C., Haddad, G.G., Ma, E. Brain Res. Mol. Brain Res. (2004) [Pubmed]
  19. The involvement of catalase in alcohol metabolism in Drosophila melanogaster larvae. van der Zel, A., Dadoo, R., Geer, B.W., Heinstra, P.W. Arch. Biochem. Biophys. (1991) [Pubmed]
  20. Increased longevity and resistance to heat shock in Drosophila melanogaster flies exposed to hypergravity. Le Bourg, E., Minois, N. C. R. Acad. Sci. III, Sci. Vie (1997) [Pubmed]
  21. Decreased mitochondrial hydrogen peroxide release in transgenic Drosophila melanogaster expressing intramitochondrial catalase. Kwong, L.K., Mockett, R.J., Bayne, A.C., Orr, W.C., Sohal, R.S. Arch. Biochem. Biophys. (2000) [Pubmed]
 
WikiGenes - Universities