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Gene Review

LMX1A  -  LIM homeobox transcription factor 1, alpha

Homo sapiens

Synonyms: LIM homeobox transcription factor 1-alpha, LIM/homeobox protein 1.1, LIM/homeobox protein LMX1A, LMX-1.1, LMX1, ...
 
 
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Disease relevance of LMX1A

 

High impact information on LMX1A

  • 2. We have used yeast genetic systems to delineate the functional domains of the Lmx1 proteins and to characterize the physical interactions between Lmx1 proteins and E47/Pan-1 that produce synergistic transcriptional activation [2].
  • The LIM-homeodomain protein Lmx1 cooperates with the basic helix-loop-helix (bHLH) protein E47/Pan-1 to activate the insulin promoter in transfected fibroblasts [2].
  • The experimental outcome was monitored by following expression of cSim1 and Lmx1, molecular markers for the duct and the mesonephros, respectively [3].
  • Cloning, expression and genomic structure of human LMX1A, and variant screening in Pima Indians [1].
  • We identified seven single nucleotide polymorphisms (SNPs) throughout the LMX1A locus and determined allele frequency distributions in 150 diabetic and 150 unaffected Pimas [1].
 

Biological context of LMX1A

 

Other interactions of LMX1A

References

  1. Cloning, expression and genomic structure of human LMX1A, and variant screening in Pima Indians. Thameem, F., Wolford, J.K., Wang, J., German, M.S., Bogardus, C., Prochazka, M. Gene (2002) [Pubmed]
  2. Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: the LIM2 domain determines specificity. Johnson, J.D., Zhang, W., Rudnick, A., Rutter, W.J., German, M.S. Mol. Cell. Biol. (1997) [Pubmed]
  3. Limb initiation and development is normal in the absence of the mesonephros. Fernandez-Teran, M., Piedra, M.E., Simandl, B.K., Fallon, J.F., Ros, M.A. Dev. Biol. (1997) [Pubmed]
  4. Identification of a human LMX1 (LMX1.1)-related gene, LMX1.2: tissue-specific expression and linkage mapping on chromosome 9. Iannotti, C.A., Inoue, H., Bernal, E., Aoki, M., Liu, L., Donis-Keller, H., German, M.S., Permutt, M.A. Genomics (1997) [Pubmed]
  5. Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13. German, M.S., Wang, J., Fernald, A.A., Espinosa, R., Le Beau, M.M., Bell, G.I. Genomics (1994) [Pubmed]
 
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