Gene Review:
LRP1 - low density lipoprotein receptor-related...
Homo sapiens
Synonyms:
A2MR, APOER, APR, Alpha-2-macroglobulin receptor, Apolipoprotein E receptor, ...
Lemmon,
Beisiegel,
Van Leuven,
Thaker,
Watson,
Lendon,
Cheng,
Zhu,
Thiry,
Callon,
Cady,
Cornish,
Chesterman,
Naot,
Dai,
Niemeier,
Henson,
Lau,
Iwatsubo,
Benoist,
Fadok,
Bruynseels,
Iandiev,
Kassem,
Hayes,
Pritchard,
Palmano,
Lambrechts,
Zhu,
Toedter,
Struble,
McPherson,
Vassiliou,
Owensby,
Muls,
van der Geer,
Chartier-Harlin,
Reichenbach,
Callon,
Grey,
Kavaslar,
Saalbach,
Pritchard,
Heeren,
Birkenmeier,
Boon,
Cornish,
Wendt,
Harris,
Ruether,
Banovic,
Lambert,
McAsey,
Hollborn,
Stas,
Bratton,
Kohen,
Ross,
Mann,
Watson,
St Clair,
Reid,
Grey,
Descamps,
Quinn,
Pye,
Wiedemann,
Nathan,
- C766T low-density lipoprotein receptor-related protein 1 (LRP1) gene polymorphism and susceptibility to breast cancer. Benes, P., Jurajda, M., Zaloudík, J., Izakovicová-Hollá, L., Vácha, J. Breast Cancer Res. (2003)
- LDL receptor-related protein and the vascular wall: implications for atherothrombosis. Llorente-Cortés, V., Badimon, L. Arterioscler. Thromb. Vasc. Biol. (2005)
- Glycoprotein 330, a member of the low density lipoprotein receptor family, binds lipoprotein lipase in vitro. Kounnas, M.Z., Chappell, D.A., Strickland, D.K., Argraves, W.S. J. Biol. Chem. (1993)
- Segments in the C-terminal folding domain of lipoprotein lipase important for binding to the low density lipoprotein receptor-related protein and to heparan sulfate proteoglycans. Nielsen, M.S., Brejning, J., García, R., Zhang, H., Hayden, M.R., Vilaró, S., Gliemann, J. J. Biol. Chem. (1997)
- Regulated expression of the trophoblast alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Differentiation and cAMP modulate protein and mRNA levels. Gåfvels, M.E., Coukos, G., Sayegh, R., Coutifaris, C., Strickland, D.K., Strauss, J.F. J. Biol. Chem. (1992)
- The low-density lipoprotein receptor-related protein regulates cancer cell survival and metastasis development. Montel, V., Gaultier, A., Lester, R.D., Campana, W.M., Gonias, S.L. Cancer Res. (2007)
- Sequencing of the coding exons of the LRP1 and LDLR genes on individual DNA samples reveals novel mutations in both genes. Van Leuven, F., Thiry, E., Lambrechts, M., Stas, L., Boon, T., Bruynseels, K., Muls, E., Descamps, O. Atherosclerosis (2001)
- Neuronal apoptosis by apolipoprotein E4 through low-density lipoprotein receptor-related protein and heterotrimeric GTPases. Hashimoto, Y., Jiang, H., Niikura, T., Ito, Y., Hagiwara, A., Umezawa, K., Abe, Y., Murayama, Y., Nishimoto, I. J. Neurosci. (2000)
- Amyloid precursor protein expression in the rat hippocampal dentate gyrus modulates during memory consolidation. Conboy, L., Murphy, K.J., Regan, C.M. J. Neurochem. (2005)
- By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation. Gardai, S.J., Xiao, Y.Q., Dickinson, M., Nick, J.A., Voelker, D.R., Greene, K.E., Henson, P.M. Cell (2003)
- LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Kounnas, M.Z., Moir, R.D., Rebeck, G.W., Bush, A.I., Argraves, W.S., Tanzi, R.E., Hyman, B.T., Strickland, D.K. Cell (1995)
- The phosphatidylserine receptor: a crucial molecular switch? Henson, P.M., Bratton, D.L., Fadok, V.A. Nat. Rev. Mol. Cell Biol. (2001)
- The low density lipoprotein receptor-related protein contributes to selective uptake of high density lipoprotein cholesteryl esters by SW872 liposarcoma cells and primary human adipocytes. Vassiliou, G., Benoist, F., Lau, P., Kavaslar, G.N., McPherson, R. J. Biol. Chem. (2001)
- Modulation of the LDL receptor and LRP levels by HIV protease inhibitors. Tran, H., Robinson, S., Mikhailenko, I., Strickland, D.K. J. Lipid Res. (2003)
- Effects of apolipoprotein E on the human immunodeficiency virus protein Tat in neuronal cultures and synaptosomes. Pocernich, C.B., Sultana, R., Hone, E., Turchan, J., Martins, R.N., Calabrese, V., Nath, A., Butterfield, D.A. J. Neurosci. Res. (2004)
- The expression of the LDL receptor-related protein (LRP) correlates with the differentiation of human neuroblastoma cells. Fabrizi, C., Businaro, R., Persichini, T., Fumagalli, L., Lauro, G.M. Brain Res. (1997)
- Estradiol regulation of astroglia and apolipoprotein E: An important role in neuronal regeneration. Struble, R.G., Nathan, B.P., Cady, C., Cheng, X., McAsey, M. Exp. Gerontol. (2007)
- Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1. Marschang, P., Brich, J., Weeber, E.J., Sweatt, J.D., Shelton, J.M., Richardson, J.A., Hammer, R.E., Herz, J. Mol. Cell. Biol. (2004)
- LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in non-small cell lung cancer cell lines. Liu, C.X., Musco, S., Lisitsina, N.M., Forgacs, E., Minna, J.D., Lisitsyn, N.A. Cancer Res. (2000)
- Sterol regulatory element-binding protein-2 negatively regulates low density lipoprotein receptor-related protein transcription. Llorente-Cortés, V., Costales, P., Bernués, J., Camino-Lopez, S., Badimon, L. J. Mol. Biol. (2006)
- Association study of the A2M and LRP1 Genes with Alzheimer disease in the Han Chinese. Bian, L., Yang, J.D., Guo, T.W., Duan, Y., Qin, W., Sun, Y., Feng, G.Y., He, L. Biol. Psychiatry (2005)
- Characterization of the soluble form of the low density lipoprotein receptor-related protein (LRP). Quinn, K.A., Pye, V.J., Dai, Y.P., Chesterman, C.N., Owensby, D.A. Exp. Cell Res. (1999)
- Expression of LRP1 by human osteoblasts: a mechanism for the delivery of lipoproteins and vitamin K1 to bone. Niemeier, A., Kassem, M., Toedter, K., Wendt, D., Ruether, W., Beisiegel, U., Heeren, J. J. Bone Miner. Res. (2005)
- Expression of LRP1 in retinal pigment epithelial cells and its regulation by growth factors. Hollborn, M., Birkenmeier, G., Saalbach, A., Iandiev, I., Reichenbach, A., Wiedemann, P., Kohen, L. Invest. Ophthalmol. Vis. Sci. (2004)
- Lactoferrin potently inhibits osteoblast apoptosis, via an LRP1-independent pathway. Grey, A., Zhu, Q., Watson, M., Callon, K., Cornish, J. Mol. Cell. Endocrinol. (2006)
- Phosphorylation of LRP1: regulation of transport and signal transduction. van der Geer, P. Trends Cardiovasc. Med. (2002)
- Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein. Beisiegel, U., Weber, W., Bengtsson-Olivecrona, G. Proc. Natl. Acad. Sci. U.S.A. (1991)
- The chicken oocyte receptor for yolk precursors as a model for studying the action of receptor-associated protein and lactoferrin. Hiesberger, T., Hermann, M., Jacobsen, L., Novak, S., Hodits, R.A., Bujo, H., Meilinger, M., Hüttinger, M., Schneider, W.J., Nimpf, J. J. Biol. Chem. (1995)
- Identification of domains on the 39-kDa protein that inhibit the binding of ligands to the low density lipoprotein receptor-related protein. Warshawsky, I., Bu, G., Schwartz, A.L. J. Biol. Chem. (1993)
- Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes. Nykjaer, A., Petersen, C.M., Møller, B., Jensen, P.H., Moestrup, S.K., Holtet, T.L., Etzerodt, M., Thøgersen, H.C., Munch, M., Andreasen, P.A. J. Biol. Chem. (1992)
- The low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor binds and mediates catabolism of bovine milk lipoprotein lipase. Chappell, D.A., Fry, G.L., Waknitz, M.A., Iverius, P.H., Williams, S.E., Strickland, D.K. J. Biol. Chem. (1992)
- The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells. Rozanov, D.V., Hahn-Dantona, E., Strickland, D.K., Strongin, A.Y. J. Biol. Chem. (2004)
- The low-density lipoprotein receptor-related protein 1 is a mitogenic receptor for lactoferrin in osteoblastic cells. Grey, A., Banovic, T., Zhu, Q., Watson, M., Callon, K., Palmano, K., Ross, J., Naot, D., Reid, I.R., Cornish, J. Mol. Endocrinol. (2004)
- C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. Ogden, C.A., deCathelineau, A., Hoffmann, P.R., Bratton, D., Ghebrehiwet, B., Fadok, V.A., Henson, P.M. J. Exp. Med. (2001)
- The low density lipoprotein receptor-related protein mediates the cellular degradation of tissue factor pathway inhibitor. Warshawsky, I., Broze, G.J., Schwartz, A.L. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein. Rebeck, G.W., Harr, S.D., Strickland, D.K., Hyman, B.T. Ann. Neurol. (1995)
- Impairment of the collagenase-3 endocytotic receptor system in cells from patients with osteoarthritis. Walling, H.W., Raggatt, L.J., Irvine, D.W., Barmina, O.Y., Toledano, J.E., Goldring, M.B., Hruska, K.A., Adkisson, H.D., Burdge, R.E., Gatt, C.J., Harwood, D.A., Partridge, N.C. Osteoarthr. Cartil. (2003)
- Association study and meta-analysis of low-density lipoprotein receptor related protein in Alzheimer's disease. Pritchard, A., Harris, J., Pritchard, C.W., St Clair, D., Lemmon, H., Lambert, J.C., Chartier-Harlin, M.C., Hayes, A., Thaker, U., Iwatsubo, T., Mann, D.M., Lendon, C. Neurosci. Lett. (2005)
- Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor. Strickland, D.K., Ashcom, J.D., Williams, S., Burgess, W.H., Migliorini, M., Argraves, W.S. J. Biol. Chem. (1990)