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ERBB2  -  v-erb-b2 erythroblastic leukemia viral...

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High impact information on ERBB2

  • ERBB2 is a receptor tyrosine kinase present on the basolateral membrane of polarized epithelia and has important functions in organ development and tumorigenesis [1].
  • The signal shows only limited sequence homology to known basolateral targeting signals and is both necessary and sufficient for correct sorting of ERBB2 [1].
  • Interestingly, LLC-PK1 cells, which are deficient for the micro 1B subunit of the AP1B adaptor complex, missort a large proportion of ERBB2 to the apical membrane domain [1].

References

  1. Basolateral targeting of ERBB2 is dependent on a novel bipartite juxtamembrane sorting signal but independent of the C-terminal ERBIN-binding domain. Dillon, C., Creer, A., Kerr, K., Kümin, A., Dickson, C. Mol. Cell. Biol. (2002) [Pubmed]
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