Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene: TfIIFbeta - Transcription factor TFIIFbeta

Drosophila melanogaster

Synonyms: ATP-dependent helicase TfIIF-beta, CG6538, dTFIIF30, factor 5, F[[S]], l(3)j3C1, RAP30, TFIIF, TFIIF30, TfIIF-beta, TFIIFbeta, TFIIF-beta, TFIIF small subunit, Transcription factor TFIIF, Transcription initiation factor IIF beta subunit, Transcription initiation factor IIF subunit beta

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Kephart, D.D., Frank, D.J., Li, C., Tan, S., Gong, D.W.

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Disease relevance of TfIIFbeta

The protein encoded by the cDNA, termed dTFIIF30, was synthesized in Escherichia coli and purified to greater than 95% homogeneity [1].

High impact information on TfIIFbeta

We first compared Eve activities in in vitro transcription systems reconstituted with either all the general transcription factors or only TBP, TFIIB, TFIIF30, and RNA polymerase II [2].
It has been suggested that 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits RNA polymerase II during elongation, but we find that the purine nucleoside analog has no effect on elongation complexes containing RNA over 500 nucleotides in length or on the action of factor 5 or DmS-II in the defined system [3].
The Drosophila TFIIF30 gene is located at region 86C on the right arm of the third chromosome [1].

Analytical, diagnostic and therapeutic context of TfIIFbeta

Dissection of transcription factor TFIIF functional domains required for initiation and elongation [4].
We report here the molecular cloning of a Drosophila cDNA encoding TFIIF beta [5].

References

Structure and function of the small subunit of TFIIF (RAP30) from Drosophila melanogaster. Frank, D.J., Tyree, C.M., George, C.P., Kadonaga, J.T. J. Biol. Chem. (1995)
Even-skipped represses transcription by binding TATA binding protein and blocking the TFIID-TATA box interaction. Li, C., Manley, J.L. Mol. Cell. Biol. (1998)
Stability of Drosophila RNA polymerase II elongation complexes in vitro. Kephart, D.D., Marshall, N.F., Price, D.H. Mol. Cell. Biol. (1992)
Dissection of transcription factor TFIIF functional domains required for initiation and elongation. Tan, S., Conaway, R.C., Conaway, J.W. Proc. Natl. Acad. Sci. U.S.A. (1995)
Molecular cloning of cDNA encoding the small subunit of Drosophila transcription initiation factor TFIIF. Gong, D.W., Mortin, M.A., Horikoshi, M., Nakatani, Y. Nucleic Acids Res. (1995)

Gene: TfIIFbeta - Transcription factor TFIIFbeta

Drosophila melanogaster

Disease relevance of TfIIFbeta

High impact information on TfIIFbeta

Analytical, diagnostic and therapeutic context of TfIIFbeta

References

Editor

Links

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