Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

CATHL3 - cathelicidin antimicrobial peptide

Gallus gallus

Synonyms: CAMP, CATH, CATH-1, CATH-3, CATHL1, ...

van Dijk, A. et al., Xiao, Y. et al., Sanchez, J.F. et al., Bals, R. et al., Xiao, Y. et al.

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Disease relevance of LOC414337

Similar to ovine cathelicidin SMAP-29, putatively mature fowlicidins displayed potent and salt-independent activities against a range of Gram-negative and Gram-positive bacteria, including antibiotic-resistant strains, with minimum inhibitory concentrations in the range of 0.4-2.0 microm for most strains [1].
Transfer of a cathelicidin peptide antibiotic gene restores bacterial killing in a cystic fibrosis xenograft model [2].
The cathelicidin motif of protegrin-3 (ProS) was overexpressed in Escherichia coli as a His-tagged protein to facilitate its purification [3].

High impact information on LOC414337

A combined expressed sequence tag (EST) and genomic based search revealed a cathelicidin-like gene located at the terminus of chromosome 2 [4].
Here, we report the cloning of a novel avian cathelicidin, chicken myeloid antimicrobial peptide 27 (CMAP27) from chicken bone marrow cells [4].
Comparative analyses between antimicrobial peptide domains showed marked similarity between CMAP27 and MAP members of the bovidae family, but not with the alpha-helical chicken cathelicidin 1 [4].
Structure-activity relationships of fowlicidin-1, a cathelicidin antimicrobial peptide in chicken [5].

Analytical, diagnostic and therapeutic context of LOC414337

Reverse transcriptase-polymerase chain reaction (RT-PCR) and 5'RACE techniques resulted in a 154 amino acid prepropeptide, homologous to chicken cathelicidin 1 (51%) and most similar to alpha-helical myeloid antibacterial peptides (MAPs; 29-33%) [4].

References

Identification and functional characterization of three chicken cathelicidins with potent antimicrobial activity. Xiao, Y., Cai, Y., Bommineni, Y.R., Fernando, S.C., Prakash, O., Gilliland, S.E., Zhang, G. J. Biol. Chem. (2006) [Pubmed]
Transfer of a cathelicidin peptide antibiotic gene restores bacterial killing in a cystic fibrosis xenograft model. Bals, R., Weiner, D.J., Meegalla, R.L., Wilson, J.M. J. Clin. Invest. (1999) [Pubmed]
Overexpression and structural study of the cathelicidin motif of the protegrin-3 precursor. Sanchez, J.F., Wojcik, F., Yang, Y.S., Strub, M.P., Strub, J.M., Van Dorsselaer, A., Martin, M., Lehrer, R., Ganz, T., Chavanieu, A., Calas, B., Aumelas, A. Biochemistry (2002) [Pubmed]
CMAP27, a novel chicken cathelicidin-like antimicrobial protein. van Dijk, A., Veldhuizen, E.J., van Asten, A.J., Haagsman, H.P. Vet. Immunol. Immunopathol. (2005) [Pubmed]
Structure-activity relationships of fowlicidin-1, a cathelicidin antimicrobial peptide in chicken. Xiao, Y., Dai, H., Bommineni, Y.R., Soulages, J.L., Gong, Y.X., Prakash, O., Zhang, G. FEBS J. (2006) [Pubmed]

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