Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene: C5 - complement component 5

Sus scrofa

Synonyms: complement component C5

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Popper, H., Kukita, I., Kumar, K.G., Hyatt, D.R., Robbins, R.A., et al.

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Disease relevance of C5

The role of the Serpulina hyodysenteriae hemolysin encoded by the tlyA gene in the pathogenesis of swine dysentery (SD) was studied. tlyA mutants of two S. hyodysenteriae strains (B204 and C5) were tested for virulence in pigs [1].

High impact information on C5

Association of C5 with complement activity traits and acute phase proteins promotes pC5 as a candidate gene for innate disease resistance [2].
Modulation of alveolar macrophage leukotriene B4 released by complement component C5 [3].
As the chemotactic activity in the serum was absorbed by an anti-C5 antibody affinity column but not by the anti-C3 or anti-macrophage chemotactic factor from skin-1 (MCFS-1) affinity column, the major chemotactic factor in the serum was postulated to be C5-derived [4].
C5 produced a prolonged acute inflammatory phase with abundant neutrophils, whereas arachidonic acid did not significantly change the inflammatory response as compared to controls [5].
The additional injection of mediators of the inflammatory reaction or their precursors, e.g., complement component C5 and arachidonic acid, caused different histological pictures [5].

Other interactions of C5

Complement component C5 is required for release of alveolar macrophage-derived neutrophil chemotactic activity [6].

Analytical, diagnostic and therapeutic context of C5

Molecular cloning and sequencing of porcine C5 gene and its association with immunological traits [2].

References

Reduced virulence of Serpulina hyodysenteriae hemolysin-negative mutants in pigs and their potential to protect pigs against challenge with a virulent strain. Hyatt, D.R., ter Huurne, A.A., van der Zeijst, B.A., Joens, L.A. Infect. Immun. (1994)
Molecular cloning and sequencing of porcine C5 gene and its association with immunological traits. Kumar, K.G., Ponsuksili, S., Schellander, K., Wimmers, K. Immunogenetics (2004)
Modulation of alveolar macrophage leukotriene B4 released by complement component C5. Robbins, R.A., Gossman, G.L., Allington, L.A., Kendall, T.J., Stull, T.W., Rennard, S.I. J. Lab. Clin. Med. (1990)
Fifth component of complement (C5)-derived high-molecular-weight macrophage chemotactic factor in normal guinea pig serum. Kukita, I., Yamamoto, T., Kawaguchi, T., Kambara, T. Inflammation (1987)
Experimental monoarthritis. Modulatory effect of injected eosinophils on influx of various types of inflammatory cells. Popper, H. Inflammation (1984)
Complement component C5 is required for release of alveolar macrophage-derived neutrophil chemotactic activity. Robbins, R.A., Russ, W.D., Thomas, K.R., Rasmussen, J.K., Kay, H.D. Am. Rev. Respir. Dis. (1987)