Gene Review:
MBL2 - mannose-binding lectin (protein C) 2, soluble
Homo sapiens
Synonyms:
COLEC1, Collectin-1, HSMBPC, MBL, MBL2D, ...
Tsujimura,
Jensenius,
Aino Rantala,
Chen,
Bernig,
Hamasaki,
Fujita,
Giacomini,
Pekka Saikku,
Terai,
Matsushita,
Madsen,
Taina Lajunen,
Sylvi Silvennoinen-Kassinen,
Zimmerman,
Koch,
Matsushita,
Rabnott,
Sim,
Olli Vainio,
Grillo,
Hou,
Lissowska,
Chanock,
Jensenius,
Fujita,
Shiraki,
Chow,
Seeney,
Thiel,
Endo,
Jensenius,
Shaw,
Kuraya,
Jensenius,
Raija Juvonen,
McCormack,
Thiel,
Aini Bloigu,
Larsen,
Anders,
Vives,
Ari Peitso,
Lozano,
Kuraya,
Fraumeni,
Matsushita,
Fujita,
Fong,
Suárez,
Fujita,
Yaeger,
Thiel,
Maija Leinonen,
Wolter,
Garred,
Yang,
Muñoz,
Tunnicliffe,
Dent,
Jensen,
Kim,
Zatonski,
Møller-Kristensen,
Vorup-Jensen,
Thiel,
Mensa,
El-Omar,
Horcajada,
Matsushita,
Baccarelli,
- Evidence of a correlation between mannose binding lectin and celiac disease: a model for other autoimmune diseases. Boniotto, M., Braida, L., Baldas, V., Not, T., Ventura, A., Vatta, S., Radillo, O., Tedesco, F., Percopo, S., Montico, M., Amoroso, A., Crovella, S. J. Mol. Med. (2005)
- Mannose-binding lectin gene polymorphism predicts hospital admissions for COPD infections. Yang, I.A., Seeney, S.L., Wolter, J.M., Anders, E.M., McCormack, J.G., Tunnicliffe, A.M., Rabnott, G.C., Shaw, J.G., Dent, A.G., Kim, S.T., Zimmerman, P.V., Fong, K.M. Genes Immun. (2003)
- Genetic polymorphisms in molecules of innate immunity and susceptibility to infection with Wuchereria bancrofti in South India. Choi, E.H., Zimmerman, P.A., Foster, C.B., Zhu, S., Kumaraswami, V., Nutman, T.B., Chanock, S.J. Genes Immun. (2001)
- MBL2 polymorphisms screening in a regional Italian CF Center. Trevisiol, C., Boniotto, M., Giglio, L., Poli, F., Morgutti, M., Crovella, S. J. Cyst. Fibros. (2005)
- Activation of complement by mannose-binding lectin on isogenic mutants of Neisseria meningitidis serogroup B. Jack, D.L., Dodds, A.W., Anwar, N., Ison, C.A., Law, A., Frosch, M., Turner, M.W., Klein, N.J. J. Immunol. (1998)
- Independent effects of genetic variations in mannose-binding lectin influence the course of HIV disease: the advantage of heterozygosity for coding mutations. Catano, G., Agan, B.K., Kulkarni, H., Telles, V., Marconi, V.C., Dolan, M.J., Ahuja, S.K. J. Infect. Dis. (2008)
- Mannose binding lectin gene deficiency increases susceptibility to traumatic brain injury in mice. Yager, P.H., You, Z., Qin, T., Kim, H.H., Takahashi, K., Ezekowitz, A.B., Stahl, G.L., Carroll, M.C., Whalen, M.J. J. Cereb. Blood Flow Metab. (2008)
- Mannose-binding lectin concentrations, MBL2 polymorphisms, and susceptibility to respiratory tract infections in young men. Rantala, A., Lajunen, T., Juvonen, R., Bloigu, A., Silvennoinen-Kassinen, S., Peitso, A., Saikku, P., Vainio, O., Leinonen, M. J. Infect. Dis. (2008)
- Mannose-binding lectin deficiency confers risk for bacterial infections in a large Hungarian cohort of patients with liver cirrhosis. Altorjay, I., Vitalis, Z., Tornai, I., Palatka, K., Kacska, S., Farkas, G., Udvardy, M., Harsfalvi, J., Dinya, T., Orosz, P., Lombay, B., Par, G., Par, A., Csak, T., Osztovits, J., Szalay, F., Csepregi, A., Lakatos, P.L., Papp, M. J. Hepatol. (2010)
- Enhancement of complement activation and opsonophagocytosis by complexes of mannose-binding lectin with mannose-binding lectin-associated serine protease after binding to Staphylococcus aureus. Neth, O., Jack, D.L., Johnson, M., Klein, N.J., Turner, M.W. J. Immunol. (2002)
- Role of hypoxia on increased blood pressure in patients with obstructive sleep apnoea. Okabe, S., Hida, W., Kikuchi, Y., Taguchi, O., Ogawa, H., Mizusawa, A., Miki, H., Shirato, K. Thorax (1995)
- Chromosome 18q paracentric inversion in a family with mental retardation and hearing loss. Keppler-Noreuil, K.M., Carroll, A.J., Finley, S.C., Descartes, M., Cody, J.D., DuPont, B.R., Gay, C.T., Leach, R.J. Am. J. Med. Genet. (1998)
- The deceit continues: an updated literature review of Munchausen Syndrome by Proxy. Sheridan, M.S. Child abuse & neglect. (2003)
- Collections and ficolins: humoral lectins of the innate immune defense. Holmskov, U., Thiel, S., Jensenius, J.C. Annu. Rev. Immunol. (2003)
- Distinct and overlapping functions of allelic forms of human mannose binding protein. Super, M., Gillies, S.D., Foley, S., Sastry, K., Schweinle, J.E., Silverman, V.J., Ezekowitz, R.A. Nat. Genet. (1992)
- A second serine protease associated with mannan-binding lectin that activates complement. Thiel, S., Vorup-Jensen, T., Stover, C.M., Schwaeble, W., Laursen, S.B., Poulsen, K., Willis, A.C., Eggleton, P., Hansen, S., Holmskov, U., Reid, K.B., Jensenius, J.C. Nature (1997)
- Glomerular deposition of mannose-binding lectin (MBL) indicates a novel mechanism of complement activation in IgA nephropathy. Endo, M., Ohi, H., Ohsawa, I., Fujita, T., Matsushita, M., Fujita, T. Nephrol. Dial. Transplant. (1998)
- Mannose-binding lectin-2 genetic variation and stomach cancer risk. Baccarelli, A., Hou, L., Chen, J., Lissowska, J., El-Omar, E.M., Grillo, P., Giacomini, S.M., Yaeger, M., Bernig, T., Zatonski, W., Fraumeni, J.F., Chanock, S.J., Chow, W.H. Int. J. Cancer (2006)
- Mannose-binding lectin binds to Ebola and Marburg envelope glycoproteins, resulting in blocking of virus interaction with DC-SIGN and complement-mediated virus neutralization. Ji, X., Olinger, G.G., Aris, S., Chen, Y., Gewurz, H., Spear, G.T. J. Gen. Virol. (2005)
- Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin. Hart, M.L., Saifuddin, M., Spear, G.T. J. Gen. Virol. (2003)
- Disease-associated mutations in human mannose-binding lectin compromise oligomerization and activity of the final protein. Larsen, F., Madsen, H.O., Sim, R.B., Koch, C., Garred, P. J. Biol. Chem. (2004)
- An analysis of genetic variation across the MBL2 locus in Dutch Caucasians indicates that 3' haplotypes could modify circulating levels of mannose-binding lectin. Bernig, T., Breunis, W., Brouwer, N., Hutchinson, A., Welch, R., Roos, D., Kuijpers, T., Chanock, S. Hum. Genet. (2005)
- Ficolins and the lectin complement pathway. Matsushita, M., Fujita, T. Immunol. Rev. (2001)
- Endothelial oxidative stress activates the lectin complement pathway: role of cytokeratin 1. Collard, C.D., Montalto, M.C., Reenstra, W.R., Buras, J.A., Stahl, G.L. Am. J. Pathol. (2001)
- Alloiococcus otitidis is a ligand for collectins and Toll-like receptor 2, and its phagocytosis is enhanced by collectins. Konishi, M., Nishitani, C., Mitsuzawa, H., Shimizu, T., Sano, H., Harimaya, A., Fujii, N., Himi, T., Kuroki, Y. Eur. J. Immunol. (2006)
- Expression of H-ficolin/Hakata antigen, mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 by human glioma cell line T98G. Kuraya, M., Matsushita, M., Endo, Y., Thiel, S., Fujita, T. Int. Immunol. (2003)
- Mannan-binding protein levels in human amniotic fluid during gestation and its interaction with collectin receptor from amnion cells. Malhotra, R., Willis, A.C., Lopez Bernal, A., Thiel, S., Sim, R.B. Immunology (1994)
- Proteolytic activities of two types of mannose-binding lectin-associated serine protease. Matsushita, M., Thiel, S., Jensenius, J.C., Terai, I., Fujita, T. J. Immunol. (2000)
- Novel MASP2 variants detected among North African and Sub-Saharan individuals. Lozano, F., Suárez, B., Muñoz, A., Jensenius, J.C., Mensa, J., Vives, J., Horcajada, J.P. Tissue Antigens (2005)
- Arg343 in human surfactant protein D governs discrimination between glucose and N-acetylglucosamine ligands. Allen, M.J., Laederach, A., Reilly, P.J., Mason, R.J., Voelker, D.R. Glycobiology (2004)
- Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2. Cseh, S., Vera, L., Matsushita, M., Fujita, T., Arlaud, G.J., Thielens, N.M. J. Immunol. (2002)
- Developmentally regulated changes in glucosidase II association with, and carbohydrate content of, the protein tyrosine phosphatase CD45. Baldwin, T.A., Ostergaard, H.L. J. Immunol. (2001)
- MASP-2, the C3 convertase generating protease of the MBLectin complement activating pathway. Vorup-Jensen, T., Jensenius, J.C., Thiel, S. Immunobiology (1998)
- Assays for the functional activity of the mannan-binding lectin pathway of complement activation. Thiel, S., Møller-Kristensen, M., Jensen, L., Jensenius, J.C. Immunobiology (2002)
- Mannose binding lectin (MBL) and HIV. Ji, X., Gewurz, H., Spear, G.T. Mol. Immunol. (2005)
- A keratin peptide inhibits mannose-binding lectin. Montalto, M.C., Collard, C.D., Buras, J.A., Reenstra, W.R., McClaine, R., Gies, D.R., Rother, R.P., Stahl, G.L. J. Immunol. (2001)
- Characterization of an equine mannose-binding lectin and its roles in disease. Podolsky, M.J., Lasker, A., Flaminio, M.J., Gowda, L.D., Ezekowitz, R.A., Takahashi, K. Biochem. Biophys. Res. Commun. (2006)
- Mannose binding lectin enhances IL-1beta and IL-10 induction by non-lipopolysaccharide (LPS) components of Neisseria meningitidis. Sprong, T., Jack, D.L., Klein, N.J., Turner, M.W., van der Ley, P., Steeghs, L., Jacobs, L., van der Meer, J.W., van Deuren, M. Cytokine (2004)
- The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20. Luo, X., Tang, Z., Rizo, J., Yu, H. Mol. Cell (2002)
- C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. Ogden, C.A., deCathelineau, A., Hoffmann, P.R., Bratton, D., Ghebrehiwet, B., Fadok, V.A., Henson, P.M. J. Exp. Med. (2001)
- Activation of the lectin complement pathway by H-ficolin (Hakata antigen). Matsushita, M., Kuraya, M., Hamasaki, N., Tsujimura, M., Shiraki, H., Fujita, T. J. Immunol. (2002)
- Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of infection in critically ill adults. Sutherland, A.M., Walley, K.R., Russell, J.A. Crit. Care Med. (2005)
- Molecular basis of opsonic defect in immunodeficient children. Sumiya, M., Super, M., Tabona, P., Levinsky, R.J., Arai, T., Turner, M.W., Summerfield, J.A. Lancet (1991)
- High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene. Lipscombe, R.J., Sumiya, M., Hill, A.V., Lau, Y.L., Levinsky, R.J., Summerfield, J.A., Turner, M.W. Hum. Mol. Genet. (1992)